ENSG00000152402

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282249 ENSG00000152402 HEK293_OSMI2_2hA HEK293_TMG_2hB GUCY1A2 protein_coding protein_coding 0.3390768 0.2564867 0.5013728 0.06772818 0.098773 0.9403122 0.08310487 0.03560609 0.08914268 0.035606090 0.08914268 1.120280 0.2282000 0.09166667 0.1286 0.03693333 0.9258269652 0.0001245387 FALSE TRUE
ENST00000347596 ENSG00000152402 HEK293_OSMI2_2hA HEK293_TMG_2hB GUCY1A2 protein_coding protein_coding 0.3390768 0.2564867 0.5013728 0.06772818 0.098773 0.9403122 0.07095797 0.18844062 0.00000000 0.034993616 0.00000000 -4.310635 0.2814458 0.76606667 0.0000 -0.76606667 0.0001245387 0.0001245387 FALSE TRUE
ENST00000526355 ENSG00000152402 HEK293_OSMI2_2hA HEK293_TMG_2hB GUCY1A2 protein_coding protein_coding 0.3390768 0.2564867 0.5013728 0.06772818 0.098773 0.9403122 0.18501400 0.03243994 0.41223014 0.009621691 0.02455738 3.314535 0.4903583 0.14230000 0.8714 0.72910000 0.0359772552 0.0001245387 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152402 E001 65.6703041 0.022448325 4.387016e-09 5.775588e-08 11 106674019 106687183 13165 - 1.832 1.415 -1.419
ENSG00000152402 E002 2.1046002 0.007528836 8.296221e-01 8.930312e-01 11 106687184 106687374 191 - 0.457 0.459 0.010
ENSG00000152402 E003 7.3463174 0.026775304 8.525288e-02 1.678155e-01 11 106687375 106687756 382 - 0.819 1.012 0.730
ENSG00000152402 E004 4.3199272 0.003933504 3.838509e-02 8.807534e-02 11 106708512 106708666 155 - 0.607 0.860 1.037
ENSG00000152402 E005 0.0000000       11 106746551 106746643 93 -      
ENSG00000152402 E006 4.6350372 0.076615622 1.276114e-01 2.308197e-01 11 106776439 106776582 144 - 0.641 0.857 0.873
ENSG00000152402 E007 8.9620979 0.069411145 6.151461e-03 1.901040e-02 11 106809993 106810478 486 - 0.839 1.165 1.207
ENSG00000152402 E008 0.6224193 0.018908660 1.635966e-01 2.798173e-01 11 106936650 106936712 63 - 0.127 0.352 1.885
ENSG00000152402 E009 11.8212834 0.059724820 8.274160e-02 1.638409e-01 11 106939460 106940178 719 - 1.005 1.191 0.674
ENSG00000152402 E010 3.5762686 0.007218668 5.743531e-02 1.222359e-01 11 106978619 106978740 122 - 0.528 0.779 1.080
ENSG00000152402 E011 1.8853425 0.007919172 7.335835e-02 1.488962e-01 11 106986070 106986131 62 - 0.339 0.616 1.400
ENSG00000152402 E012 2.4952667 0.123406815 9.052870e-01 9.436929e-01 11 107017753 107018476 724 - 0.504 0.462 -0.211