ENSG00000152380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282226 ENSG00000152380 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM151B protein_coding protein_coding 1.272635 0.9462047 2.053611 0.07602027 0.1118315 1.10978 0.66396868 0.36351893 1.0084755 0.042585963 0.06366461 1.4471580 0.5290833 0.38473333 0.49720000 0.11246667 0.599760078 0.006842817 FALSE TRUE
ENST00000502608 ENSG00000152380 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM151B protein_coding nonsense_mediated_decay 1.272635 0.9462047 2.053611 0.07602027 0.1118315 1.10978 0.22095858 0.33157701 0.2514557 0.044175748 0.02719941 -0.3856446 0.1721458 0.35043333 0.12226667 -0.22816667 0.006842817 0.006842817 TRUE FALSE
ENST00000507084 ENSG00000152380 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM151B protein_coding processed_transcript 1.272635 0.9462047 2.053611 0.07602027 0.1118315 1.10978 0.06962049 0.06629958 0.2166839 0.066299584 0.11087271 1.5709350 0.0515500 0.07750000 0.10016667 0.02266667 0.805509182 0.006842817   FALSE
ENST00000509292 ENSG00000152380 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM151B protein_coding retained_intron 1.272635 0.9462047 2.053611 0.07602027 0.1118315 1.10978 0.24670555 0.17120930 0.4269165 0.088885809 0.06108081 1.2697005 0.1707958 0.17163333 0.20586667 0.03423333 0.845780967 0.006842817 FALSE TRUE
ENST00000511718 ENSG00000152380 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM151B protein_coding processed_transcript 1.272635 0.9462047 2.053611 0.07602027 0.1118315 1.10978 0.07138171 0.01359990 0.1500793 0.007192103 0.02455118 2.7619345 0.0764000 0.01566667 0.07443333 0.05876667 0.313249933 0.006842817 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152380 E001 0.3332198 0.029303920 0.58988544   5 80487969 80487985 17 + 0.089 0.167 1.047
ENSG00000152380 E002 3.2314443 0.026825674 0.02933455 0.07065375 5 80487986 80488099 114 + 0.449 0.790 1.512
ENSG00000152380 E003 3.9333478 0.005443659 0.33967741 0.48360475 5 80488100 80488123 24 + 0.620 0.754 0.562
ENSG00000152380 E004 5.6904443 0.003225920 0.55104589 0.68056111 5 80488124 80488148 25 + 0.777 0.850 0.288
ENSG00000152380 E005 1.6553645 0.009632491 0.78864665 0.86469741 5 80495053 80495283 231 + 0.412 0.458 0.237
ENSG00000152380 E006 0.4407149 0.023136309 1.00000000 1.00000000 5 80499885 80499985 101 + 0.162 0.166 0.045
ENSG00000152380 E007 6.9298695 0.002706566 0.05045532 0.10997675 5 80501792 80501804 13 + 0.793 1.015 0.844
ENSG00000152380 E008 12.4322707 0.001768924 0.55642295 0.68507165 5 80501805 80501917 113 + 1.099 1.149 0.181
ENSG00000152380 E009 2.8882005 0.007061000 0.26752045 0.40584368 5 80505943 80506076 134 + 0.643 0.458 -0.862
ENSG00000152380 E010 0.4439371 0.021821155 0.26947863 0.40799429 5 80510714 80510739 26 + 0.225 0.000 -11.009
ENSG00000152380 E011 1.6618090 0.008357271 0.28814783 0.42868833 5 80510740 80511086 347 + 0.483 0.287 -1.124
ENSG00000152380 E012 14.2196908 0.001516763 0.08024399 0.15993502 5 80513604 80513769 166 + 1.227 1.070 -0.560
ENSG00000152380 E013 0.2987644 0.027634954 0.48641673   5 80518764 80518930 167 + 0.162 0.000 -10.424
ENSG00000152380 E014 14.1834421 0.001457988 0.48042104 0.61871996 5 80519693 80519910 218 + 1.184 1.119 -0.230
ENSG00000152380 E015 9.7108802 0.002146932 0.60606968 0.72631977 5 80522003 80522138 136 + 1.031 0.974 -0.209
ENSG00000152380 E016 1.7661810 0.009585954 0.78665073 0.86336346 5 80522139 80522524 386 + 0.412 0.458 0.240
ENSG00000152380 E017 11.7433580 0.001538734 0.78735408 0.86381656 5 80541673 80542563 891 + 1.099 1.070 -0.102