ENSG00000152348

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282185 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding protein_coding 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 1.1041105 0.8603130 1.52140359 0.16087387 0.26952312 0.8152482 0.29580417 0.4000333 0.260766667 -0.13926667 1.182559e-01 1.05847e-13 FALSE TRUE
ENST00000355178 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding protein_coding 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 0.2126238 0.3261831 0.22220834 0.17889899 0.05962977 -0.5338273 0.07874583 0.1749333 0.037866667 -0.13706667 6.685910e-01 1.05847e-13 FALSE TRUE
ENST00000458350 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding protein_coding 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 0.6221530 0.3070569 1.04393163 0.05976539 0.15150258 1.7329678 0.16497917 0.1442667 0.187866667 0.04360000 8.120798e-01 1.05847e-13 FALSE TRUE
ENST00000510085 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding protein_coding 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 0.1440793 0.0000000 0.10028647 0.00000000 0.10028647 3.4631838 0.05070417 0.0000000 0.018533333 0.01853333 9.855472e-01 1.05847e-13   FALSE
ENST00000513443 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding protein_coding 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 0.0719426 0.1782846 0.01417072 0.11203028 0.01417072 -2.9615824 0.02736250 0.0750000 0.002633333 -0.07236667 1.270475e-01 1.05847e-13 FALSE FALSE
ENST00000513634 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding protein_coding 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 1.2343455 0.0000000 2.48393324 0.00000000 0.53433114 7.9622790 0.27232917 0.0000000 0.421233333 0.42123333 1.058470e-13 1.05847e-13 FALSE TRUE
ENST00000514253 ENSG00000152348 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG10 protein_coding processed_transcript 3.798199 2.1197 5.784434 0.2628693 0.6061709 1.444018 0.2738371 0.3347706 0.09016289 0.08199632 0.03228697 -1.7832885 0.07550417 0.1554000 0.016200000 -0.13920000 2.952842e-05 1.05847e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152348 E001 0.2924217 0.0298410639 4.702728e-01   5 81972023 81972024 2 + 0.165 0.000 -10.368
ENSG00000152348 E002 0.2924217 0.0298410639 4.702728e-01   5 81972025 81972025 1 + 0.165 0.000 -10.367
ENSG00000152348 E003 7.6929476 0.0022974771 8.446792e-01 9.033439e-01 5 81972026 81972050 25 + 0.911 0.945 0.125
ENSG00000152348 E004 13.3812059 0.0013933526 4.922530e-01 6.294394e-01 5 81972051 81972091 41 + 1.165 1.112 -0.191
ENSG00000152348 E005 15.8213166 0.0012359273 3.447384e-01 4.888374e-01 5 81972092 81972156 65 + 1.240 1.169 -0.251
ENSG00000152348 E006 18.9610626 0.0010066882 5.273494e-01 6.604400e-01 5 81972157 81972260 104 + 1.304 1.266 -0.136
ENSG00000152348 E007 9.8515855 0.0018551582 5.096287e-01 6.449278e-01 5 81972261 81972306 46 + 1.047 0.988 -0.220
ENSG00000152348 E008 1.4736576 0.0125407327 5.179331e-02 1.123500e-01 5 81972307 81972591 285 + 0.228 0.574 1.990
ENSG00000152348 E009 0.6632174 0.0687883101 1.052077e-01 1.984081e-01 5 81973155 81973301 147 + 0.090 0.375 2.573
ENSG00000152348 E010 8.8677332 0.0039062581 2.164661e-01 3.461569e-01 5 81976193 81976327 135 + 1.029 0.897 -0.494
ENSG00000152348 E011 0.1472490 0.0447480817 1.000000e+00   5 81987558 81987558 1 + 0.090 0.000 -9.367
ENSG00000152348 E012 27.0558192 0.0007333402 1.692921e-01 2.872589e-01 5 81987559 81987678 120 + 1.468 1.387 -0.279
ENSG00000152348 E013 0.2966881 0.0290785164 4.715341e-01   5 81987679 81987679 1 + 0.165 0.000 -10.367
ENSG00000152348 E014 1.7253074 0.0413082932 4.567408e-01 5.971208e-01 5 82009711 82010122 412 + 0.377 0.517 0.725
ENSG00000152348 E015 27.1735018 0.0065453369 5.338312e-01 6.659635e-01 5 82058495 82058602 108 + 1.418 1.474 0.195
ENSG00000152348 E016 0.0000000       5 82111392 82111455 64 +      
ENSG00000152348 E017 9.2026562 0.0785001793 6.301912e-06 4.385924e-05 5 82147190 82148117 928 + 0.548 1.299 2.898
ENSG00000152348 E018 15.7643559 0.0426623177 4.704991e-02 1.039132e-01 5 82164399 82164444 46 + 1.290 1.069 -0.785
ENSG00000152348 E019 25.0531187 0.0553634393 1.856212e-01 3.082709e-01 5 82164445 82164537 93 + 1.448 1.331 -0.405
ENSG00000152348 E020 31.1048565 0.0021884621 1.497015e-01 2.612724e-01 5 82178490 82178587 98 + 1.529 1.448 -0.278
ENSG00000152348 E021 0.0000000       5 82242797 82242882 86 +      
ENSG00000152348 E022 28.7681910 0.0006892162 1.613236e-01 2.768146e-01 5 82252562 82252659 98 + 1.491 1.411 -0.276
ENSG00000152348 E023 0.0000000       5 82252660 82252713 54 +      
ENSG00000152348 E024 29.1982201 0.0006792319 4.513892e-01 5.923481e-01 5 82253314 82253429 116 + 1.485 1.448 -0.126
ENSG00000152348 E025 0.0000000       5 82253430 82253431 2 +      
ENSG00000152348 E026 78.6091908 0.0101329728 5.756357e-02 1.224400e-01 5 82254068 82256133 2066 + 1.851 1.950 0.332
ENSG00000152348 E027 9.2493171 0.0024694031 1.688145e-04 8.301034e-04 5 82276145 82276857 713 + 0.815 1.219 1.492