ENSG00000152332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000489294 ENSG00000152332 HEK293_OSMI2_2hA HEK293_TMG_2hB UHMK1 protein_coding protein_coding 9.962267 2.800369 16.41389 0.7654522 0.6021403 2.546964 6.921710 0.8011015 14.653815 0.1034145 1.187732 4.1762342 0.5724250 0.3170333 0.89436667 0.5773333 0.0009661997 0.0009661997 FALSE TRUE
ENST00000545294 ENSG00000152332 HEK293_OSMI2_2hA HEK293_TMG_2hB UHMK1 protein_coding protein_coding 9.962267 2.800369 16.41389 0.7654522 0.6021403 2.546964 2.761963 1.8748305 1.336462 0.8027802 1.336462 -0.4852617 0.3864875 0.6247333 0.07986667 -0.5448667 0.0387318086 0.0009661997 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152332 E001 0.00000       1 162497251 162497296 46 +      
ENSG00000152332 E002 0.00000       1 162497805 162497817 13 +      
ENSG00000152332 E003 42.85435 0.0071341224 1.317814e-05 8.512252e-05 1 162497818 162498084 267 + 1.430 1.295 -0.468
ENSG00000152332 E004 54.49918 0.0009075613 5.186580e-06 3.677741e-05 1 162498085 162498268 184 + 1.522 1.488 -0.117
ENSG00000152332 E005 58.06390 0.0004258850 1.462870e-10 2.511430e-09 1 162499955 162500063 109 + 1.562 1.362 -0.686
ENSG00000152332 E006 85.10951 0.0003248647 8.668083e-17 3.762067e-15 1 162500064 162500247 184 + 1.727 1.472 -0.870
ENSG00000152332 E007 1.47906 0.0091123264 1.504411e-01 2.622844e-01 1 162500248 162500912 665 + 0.292 0.001 -9.273
ENSG00000152332 E008 95.65830 0.0004260984 7.292045e-13 1.828290e-11 1 162500913 162501104 192 + 1.768 1.654 -0.387
ENSG00000152332 E009 67.94655 0.0016798320 1.805879e-07 1.745591e-06 1 162503754 162503848 95 + 1.619 1.559 -0.202
ENSG00000152332 E010 69.77942 0.0014040872 9.410743e-08 9.603514e-07 1 162512500 162512576 77 + 1.630 1.572 -0.199
ENSG00000152332 E011 85.42981 0.0049821378 3.721681e-04 1.666575e-03 1 162512725 162512823 99 + 1.704 1.773 0.232
ENSG00000152332 E012 78.61447 0.0003474857 3.411996e-05 2.001339e-04 1 162518102 162518190 89 + 1.669 1.740 0.243
ENSG00000152332 E013 1674.70136 0.0166003074 1.277280e-10 2.215094e-09 1 162522404 162529631 7228 + 2.935 3.336 1.334