ENSG00000152270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282096 ENSG00000152270 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE3B protein_coding protein_coding 5.749157 1.69535 8.947797 0.1812521 0.3642282 2.393076 4.4810438 1.0342554 7.6089802 0.0237293 0.1214362 2.8671233 0.7121958 0.6218333 0.8521 0.2302667 0.008462988 0.008462988 FALSE TRUE
MSTRG.5208.5 ENSG00000152270 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE3B protein_coding   5.749157 1.69535 8.947797 0.1812521 0.3642282 2.393076 0.6677134 0.5396397 0.6024216 0.2266557 0.3702391 0.1560391 0.1734292 0.2989000 0.0690 -0.2299000 0.277268228 0.008462988 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152270 E001 7.8375643 0.0264208236 2.363936e-01 3.699847e-01 11 14643804 14643830 27 + 0.883 0.676 -0.825
ENSG00000152270 E002 37.4947094 0.0007653251 1.099809e-04 5.678962e-04 11 14643831 14644259 429 + 1.524 1.184 -1.185
ENSG00000152270 E003 44.2375301 0.0381325626 8.293883e-03 2.452781e-02 11 14644260 14644889 630 + 1.588 1.273 -1.089
ENSG00000152270 E004 42.6018325 0.0265536443 2.807678e-03 9.697646e-03 11 14644890 14645053 164 + 1.577 1.230 -1.198
ENSG00000152270 E005 0.1472490 0.0427055257 1.000000e+00   11 14698839 14699353 515 + 0.057 0.000 -8.746
ENSG00000152270 E006 0.2944980 0.3504978286 1.000000e+00   11 14700654 14700926 273 + 0.108 0.000 -8.841
ENSG00000152270 E007 27.3412006 0.0027457503 6.487447e-04 2.711528e-03 11 14771937 14771987 51 + 1.392 1.032 -1.277
ENSG00000152270 E008 2.8129602 0.0054382520 5.089982e-01 6.443624e-01 11 14771988 14776663 4676 + 0.531 0.398 -0.676
ENSG00000152270 E009 40.6348943 0.0011426126 2.223998e-04 1.059549e-03 11 14786437 14786532 96 + 1.554 1.244 -1.075
ENSG00000152270 E010 45.3214606 0.0005197961 2.168398e-05 1.333192e-04 11 14786533 14786685 153 + 1.603 1.262 -1.177
ENSG00000152270 E011 0.1515154 0.0421738894 1.000000e+00   11 14788939 14789105 167 + 0.057 0.000 -8.751
ENSG00000152270 E012 46.6872708 0.0004876271 1.658960e-03 6.150752e-03 11 14789106 14789242 137 + 1.606 1.372 -0.804
ENSG00000152270 E013 47.6422081 0.0004845459 1.044981e-03 4.114659e-03 11 14803944 14804050 107 + 1.615 1.372 -0.835
ENSG00000152270 E014 67.8225277 0.0005192837 2.533514e-02 6.256327e-02 11 14818183 14818393 211 + 1.750 1.619 -0.447
ENSG00000152270 E015 36.9549260 0.0006379000 5.653240e-02 1.206496e-01 11 14819136 14819209 74 + 1.496 1.343 -0.528
ENSG00000152270 E016 46.7942331 0.0009335613 1.351031e-01 2.412313e-01 11 14830698 14830846 149 + 1.587 1.482 -0.362
ENSG00000152270 E017 42.0680035 0.0007513985 3.744364e-01 5.188480e-01 11 14831640 14831777 138 + 1.535 1.471 -0.221
ENSG00000152270 E018 33.2631346 0.0006265589 9.172277e-01 9.517099e-01 11 14832722 14832833 112 + 1.428 1.436 0.026
ENSG00000152270 E019 34.9654416 0.0025483734 8.014817e-01 8.735124e-01 11 14834982 14835095 114 + 1.451 1.470 0.066
ENSG00000152270 E020 54.3274753 0.0005948140 9.738229e-01 9.876803e-01 11 14843827 14844026 200 + 1.637 1.634 -0.009
ENSG00000152270 E021 50.1641749 0.0005020200 1.164541e-01 2.148940e-01 11 14859043 14859246 204 + 1.582 1.677 0.323
ENSG00000152270 E022 49.7724714 0.0004983307 5.197197e-03 1.646670e-02 11 14861205 14861366 162 + 1.564 1.729 0.559
ENSG00000152270 E023 78.6152251 0.0009827733 3.340050e-01 4.777693e-01 11 14867506 14867758 253 + 1.783 1.832 0.165
ENSG00000152270 E024 304.2255687 0.0006232445 1.339163e-28 1.989807e-26 11 14869461 14872044 2584 + 2.317 2.559 0.805