ENSG00000152253

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282074 ENSG00000152253 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC25 protein_coding protein_coding 26.82716 19.55168 37.30328 1.100295 1.583876 0.9316589 16.416645 15.5509512 19.983157 1.6664972 0.6669627 0.3615761 0.63365000 0.79126667 0.5371333 -0.25413333 0.002547108 0.002547108 FALSE TRUE
MSTRG.19444.1 ENSG00000152253 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC25 protein_coding   26.82716 19.55168 37.30328 1.100295 1.583876 0.9316589 2.900458 0.6132011 6.817048 0.3192744 0.3791632 3.4534921 0.08583333 0.02996667 0.1840667 0.15410000 0.108405457 0.002547108 FALSE TRUE
MSTRG.19444.5 ENSG00000152253 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC25 protein_coding   26.82716 19.55168 37.30328 1.100295 1.583876 0.9316589 5.069184 2.6382000 8.039085 0.7145772 1.8798219 1.6038126 0.19165000 0.13956667 0.2121333 0.07256667 0.565587064 0.002547108 FALSE TRUE
MSTRG.19444.6 ENSG00000152253 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC25 protein_coding   26.82716 19.55168 37.30328 1.100295 1.583876 0.9316589 1.529484 0.5007567 2.369800 0.2108239 0.4696109 2.2201324 0.05396250 0.02656667 0.0641000 0.03753333 0.196984753 0.002547108 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152253 E001 3.1224355 0.0099876417 9.218804e-06 6.178056e-05 2 168833974 168833994 21 - 0.817 0.000 -14.369
ENSG00000152253 E002 7.1155874 0.0027561862 1.782144e-04 8.702542e-04 2 168833995 168834131 137 - 1.064 0.580 -1.918
ENSG00000152253 E003 4.8163829 0.0053982147 1.144284e-04 5.881843e-04 2 168834132 168834196 65 - 0.938 0.343 -2.676
ENSG00000152253 E004 4.0005293 0.0072849780 9.520053e-04 3.794621e-03 2 168834197 168834222 26 - 0.866 0.342 -2.405
ENSG00000152253 E005 5.5735907 0.0035732256 2.366878e-02 5.912865e-02 2 168851786 168851982 197 - 0.925 0.623 -1.210
ENSG00000152253 E006 7.9025437 0.0025771536 9.485342e-03 2.750057e-02 2 168865145 168865396 252 - 1.064 0.763 -1.141
ENSG00000152253 E007 226.0820656 0.0074053072 9.385537e-04 3.749287e-03 2 168870891 168871555 665 - 2.279 2.436 0.523
ENSG00000152253 E008 185.7772529 0.0002625394 3.709107e-06 2.721032e-05 2 168873585 168873683 99 - 2.212 2.338 0.421
ENSG00000152253 E009 200.6177043 0.0015335573 4.142984e-06 3.002126e-05 2 168876072 168876176 105 - 2.236 2.376 0.468
ENSG00000152253 E010 313.1985582 0.0004386320 1.750870e-01 2.947946e-01 2 168877238 168877384 147 - 2.503 2.485 -0.061
ENSG00000152253 E011 0.1482932 0.0408939498 3.354557e-01   2 168884848 168884907 60 - 0.000 0.146 10.892
ENSG00000152253 E012 232.9439249 0.0001980141 1.908329e-03 6.941766e-03 2 168889226 168889291 66 - 2.393 2.333 -0.201
ENSG00000152253 E013 0.5891098 0.0182373874 8.681925e-02 1.703036e-01 2 168889292 168889293 2 - 0.313 0.000 -11.975
ENSG00000152253 E014 285.8975174 0.0008205097 2.179519e-05 1.339378e-04 2 168889387 168889533 147 - 2.492 2.404 -0.292
ENSG00000152253 E015 150.1842425 0.0067292481 2.237467e-02 5.645654e-02 2 168890318 168890456 139 - 2.218 2.117 -0.338
ENSG00000152253 E016 0.1515154 0.0425289881 7.052678e-01   2 168890529 168890686 158 - 0.102 0.000 -9.976
ENSG00000152253 E017 0.0000000       2 168913196 168913199 4 -      
ENSG00000152253 E018 0.0000000       2 168913200 168913371 172 -