ENSG00000152242

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587591 ENSG00000152242 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf25 protein_coding protein_coding 8.324055 3.807484 14.65145 0.9536229 0.3250169 1.941334 1.8974305 0.0000000 4.6682435 0.00000000 0.09088655 8.8698232 0.14730000 0.00000000 0.3188667 0.31886667 1.981115e-28 1.981115e-28 FALSE TRUE
ENST00000615052 ENSG00000152242 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf25 protein_coding protein_coding 8.324055 3.807484 14.65145 0.9536229 0.3250169 1.941334 0.6439528 0.5637390 1.2002998 0.08437208 0.06172807 1.0768979 0.09732083 0.17440000 0.0819000 -0.09250000 3.508739e-01 1.981115e-28 FALSE TRUE
ENST00000619301 ENSG00000152242 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf25 protein_coding protein_coding 8.324055 3.807484 14.65145 0.9536229 0.3250169 1.941334 2.5474040 0.6959037 3.8633983 0.08911153 0.44578653 2.4560565 0.31046667 0.19463333 0.2629333 0.06830000 3.638778e-01 1.981115e-28 FALSE TRUE
MSTRG.15745.1 ENSG00000152242 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf25 protein_coding   8.324055 3.807484 14.65145 0.9536229 0.3250169 1.941334 0.1364216 0.3192436 0.1573745 0.25075575 0.15737445 -0.9760759 0.02710000 0.06366667 0.0112000 -0.05246667 4.084092e-01 1.981115e-28 FALSE FALSE
MSTRG.15745.4 ENSG00000152242 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf25 protein_coding   8.324055 3.807484 14.65145 0.9536229 0.3250169 1.941334 2.4491666 2.0324494 3.4548887 0.72358328 0.54898422 0.7625087 0.35022917 0.50980000 0.2359667 -0.27383333 5.471680e-03 1.981115e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152242 E001 0.2987644 0.0290785164 6.213018e-01   18 46173505 46173523 19 + 0.151 0.000 -9.062
ENSG00000152242 E002 1.9388035 0.0819579423 8.285728e-02 1.640202e-01 18 46173524 46173552 29 + 0.544 0.178 -2.300
ENSG00000152242 E003 19.1443917 0.0066093552 4.846957e-03 1.550533e-02 18 46173553 46173712 160 + 1.354 1.086 -0.950
ENSG00000152242 E004 1.3349319 0.0099187343 1.950002e-01 3.199872e-01 18 46174019 46174033 15 + 0.425 0.179 -1.706
ENSG00000152242 E005 4.8037331 0.0036440875 6.675669e-01 7.747684e-01 18 46174034 46174085 52 + 0.762 0.706 -0.229
ENSG00000152242 E006 10.3227946 0.0048291591 2.630052e-01 4.008653e-01 18 46174086 46174150 65 + 1.064 0.937 -0.469
ENSG00000152242 E007 22.2114336 0.0010219452 1.308219e-02 3.610117e-02 18 46174151 46174330 180 + 1.396 1.198 -0.692
ENSG00000152242 E008 103.6009837 0.0003061431 5.767379e-08 6.130696e-07 18 46215811 46216217 407 + 2.055 1.856 -0.667
ENSG00000152242 E009 117.2817696 0.0002560539 4.419651e-05 2.523021e-04 18 46216218 46216595 378 + 2.093 1.960 -0.446
ENSG00000152242 E010 2.2895388 0.0063587617 7.453148e-01 8.333981e-01 18 46216596 46219242 2647 + 0.488 0.550 0.294
ENSG00000152242 E011 0.1451727 0.0442820892 1.000000e+00   18 46228756 46228896 141 + 0.082 0.000 -9.249
ENSG00000152242 E012 3.0172606 0.0052373975 3.754615e-02 8.649082e-02 18 46231779 46232936 1158 + 0.458 0.785 1.446
ENSG00000152242 E013 8.7360236 0.0135914644 7.394428e-01 8.291323e-01 18 46240005 46240187 183 + 0.949 0.986 0.138
ENSG00000152242 E014 57.2150467 0.0004052580 3.977785e-01 5.415396e-01 18 46253697 46253823 127 + 1.757 1.724 -0.110
ENSG00000152242 E015 702.3658904 0.0003119355 1.750972e-15 6.416178e-14 18 46262929 46266992 4064 + 2.802 2.876 0.244