ENSG00000152223

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282041 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding protein_coding 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.48249049 0.21173156 0.502595337 0.21173156 0.251362306 1.2090062 0.19901667 0.17223333 0.217833333 0.045600000 6.998131e-01 2.621871e-09 FALSE TRUE
ENST00000586655 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding retained_intron 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.18221377 0.06683600 0.126082477 0.03545192 0.020547649 0.8246270 0.06867917 0.05016667 0.055000000 0.004833333 8.562426e-01 2.621871e-09 FALSE TRUE
ENST00000587262 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding protein_coding 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.38885098 0.03614967 0.172677216 0.03614967 0.121577644 1.9849045 0.14266667 0.02940000 0.073466667 0.044066667 7.817032e-01 2.621871e-09 FALSE TRUE
ENST00000587973 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding retained_intron 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.23741715 0.44833246 0.009266375 0.15032423 0.009266375 -4.5722374 0.13307917 0.34806667 0.004133333 -0.343933333 3.673385e-05 2.621871e-09 FALSE TRUE
ENST00000592272 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding nonsense_mediated_decay 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.12741375 0.13723866 0.161087681 0.13723866 0.161087681 0.2165794 0.05817083 0.09730000 0.070766667 -0.026533333 9.487815e-01 2.621871e-09 TRUE TRUE
ENST00000696485 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding nonsense_mediated_decay 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.08005937 0.07500523 0.000000000 0.07500523 0.000000000 -3.0875517 0.03410417 0.06100000 0.000000000 -0.061000000 6.497449e-01 2.621871e-09 TRUE TRUE
ENST00000696489 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding protein_coding 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.19396276 0.18020542 0.089975620 0.18020542 0.045793105 -0.9279101 0.08449583 0.15143333 0.038733333 -0.112700000 9.615950e-01 2.621871e-09 FALSE TRUE
ENST00000696490 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding protein_coding 2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.51937723 0.00000000 1.015438227 0.00000000 0.123402093 6.6800968 0.18321667 0.00000000 0.444033333 0.444033333 2.621871e-09 2.621871e-09 FALSE TRUE
MSTRG.15740.13 ENSG00000152223 HEK293_OSMI2_2hA HEK293_TMG_2hB EPG5 protein_coding   2.446884 1.276677 2.298943 0.06791604 0.04375061 0.8435826 0.05722297 0.00000000 0.165948798 0.00000000 0.090441973 4.1370837 0.02090000 0.00000000 0.071700000 0.071700000 3.091523e-01 2.621871e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152223 E001 0.0000000       18 45800581 45800596 16 -      
ENSG00000152223 E002 0.2214452 0.0395818150 2.861822e-01   18 45800597 45800604 8 - 0.000 0.159 10.595
ENSG00000152223 E003 0.4428904 0.5027806661 1.762725e-01 2.963850e-01 18 45800605 45800616 12 - 0.000 0.286 13.455
ENSG00000152223 E004 2.1065842 0.0552390089 9.340364e-03 2.713214e-02 18 45800617 45800890 274 - 0.235 0.729 2.599
ENSG00000152223 E005 0.0000000       18 45806648 45806787 140 -      
ENSG00000152223 E006 0.0000000       18 45847609 45847620 12 -      
ENSG00000152223 E007 35.7644250 0.0200737444 1.625655e-10 2.768070e-09 18 45847621 45848682 1062 - 1.220 1.816 2.048
ENSG00000152223 E008 8.0016316 0.0023036560 1.712648e-03 6.321968e-03 18 45848683 45848823 141 - 0.745 1.126 1.439
ENSG00000152223 E009 6.8559799 0.0539306565 2.013806e-03 7.268785e-03 18 45848824 45848961 138 - 0.589 1.107 2.034
ENSG00000152223 E010 51.5741181 0.0005304275 8.427042e-11 1.506253e-09 18 45848962 45850706 1745 - 1.542 1.881 1.149
ENSG00000152223 E011 135.4954042 0.0109254201 3.193001e-03 1.083476e-02 18 45850707 45852649 1943 - 2.047 2.227 0.600
ENSG00000152223 E012 0.7708142 0.0153787590 4.231697e-01 5.662798e-01 18 45855353 45855572 220 - 0.292 0.159 -1.120
ENSG00000152223 E013 13.5433489 0.0100241021 3.512405e-01 4.954540e-01 18 45855573 45855687 115 - 1.098 1.217 0.425
ENSG00000152223 E014 0.0000000       18 45857726 45857852 127 -      
ENSG00000152223 E015 20.1587628 0.0010041235 2.359151e-01 3.694438e-01 18 45857853 45858068 216 - 1.262 1.379 0.410
ENSG00000152223 E016 16.6793337 0.0012855928 2.833335e-01 4.234146e-01 18 45858566 45858782 217 - 1.194 1.310 0.407
ENSG00000152223 E017 17.7806776 0.0010435441 6.731591e-01 7.789310e-01 18 45860104 45860346 243 - 1.268 1.260 -0.026
ENSG00000152223 E018 16.4158329 0.0222987973 5.425529e-01 6.732805e-01 18 45865615 45865759 145 - 1.239 1.198 -0.146
ENSG00000152223 E019 19.8510419 0.0044306802 4.537926e-01 5.944972e-01 18 45866798 45867007 210 - 1.268 1.355 0.306
ENSG00000152223 E020 14.8455372 0.0012896104 8.654639e-01 9.173280e-01 18 45867563 45867748 186 - 1.181 1.192 0.041
ENSG00000152223 E021 11.2487227 0.0017638117 4.315424e-02 9.682698e-02 18 45870567 45870742 176 - 1.137 0.952 -0.678
ENSG00000152223 E022 9.7733501 0.0017839291 1.234493e-01 2.248673e-01 18 45876236 45876339 104 - 1.072 0.930 -0.525
ENSG00000152223 E023 6.1079821 0.0273120561 1.082900e-01 2.030052e-01 18 45876340 45876342 3 - 0.914 0.698 -0.851
ENSG00000152223 E024 11.7371380 0.0016017485 8.916195e-01 9.347814e-01 18 45878376 45878448 73 - 1.072 1.111 0.143
ENSG00000152223 E025 15.9951728 0.0016184878 6.766879e-01 7.815906e-01 18 45879013 45879214 202 - 1.187 1.250 0.222
ENSG00000152223 E026 7.9296332 0.0021067473 9.132512e-01 9.490236e-01 18 45880075 45880223 149 - 0.938 0.952 0.049
ENSG00000152223 E027 9.2356093 0.0019424285 1.444251e-01 2.540464e-01 18 45882274 45882431 158 - 1.044 0.907 -0.513
ENSG00000152223 E028 6.0007524 0.0055207134 1.490463e-01 2.603823e-01 18 45882432 45882487 56 - 0.901 0.733 -0.659
ENSG00000152223 E029 12.1483789 0.0016575251 5.635002e-01 6.909607e-01 18 45884617 45884811 195 - 1.072 1.154 0.295
ENSG00000152223 E030 10.9317296 0.0213257300 7.619964e-01 8.457068e-01 18 45887751 45887907 157 - 1.063 1.051 -0.043
ENSG00000152223 E031 9.1236312 0.0018907175 7.976476e-01 8.708957e-01 18 45889798 45889940 143 - 0.995 0.992 -0.008
ENSG00000152223 E032 0.4772466 0.0217681645 3.004822e-01 4.421738e-01 18 45889941 45891381 1441 - 0.093 0.275 1.878
ENSG00000152223 E033 0.8168978 0.0149181037 4.241336e-01 5.671221e-01 18 45896563 45899403 2841 - 0.292 0.159 -1.120
ENSG00000152223 E034 13.0287911 0.0013715944 6.738734e-01 7.794518e-01 18 45899404 45899566 163 - 1.114 1.180 0.235
ENSG00000152223 E035 0.0000000       18 45899567 45900995 1429 -      
ENSG00000152223 E036 11.3581459 0.0152850044 1.130374e-01 2.099675e-01 18 45900996 45901167 172 - 1.145 0.990 -0.563
ENSG00000152223 E037 0.1472490 0.0428126144 8.100360e-01   18 45901168 45902017 850 - 0.093 0.000 -13.165
ENSG00000152223 E038 0.1472490 0.0428126144 8.100360e-01   18 45902018 45902150 133 - 0.093 0.000 -13.165
ENSG00000152223 E039 0.0000000       18 45902151 45902712 562 -      
ENSG00000152223 E040 9.9631246 0.0399237118 1.356873e-01 2.420782e-01 18 45903973 45904117 145 - 1.098 0.906 -0.711
ENSG00000152223 E041 0.0000000       18 45907164 45907289 126 -      
ENSG00000152223 E042 0.1482932 0.0414575184 2.883511e-01   18 45907865 45907957 93 - 0.000 0.158 13.358
ENSG00000152223 E043 8.6881719 0.0305923038 4.003552e-03 1.315174e-02 18 45907958 45908081 124 - 1.097 0.697 -1.533
ENSG00000152223 E044 9.7651439 0.0349677408 3.693961e-01 5.138220e-01 18 45910521 45910742 222 - 1.054 0.956 -0.361
ENSG00000152223 E045 10.6441722 0.0021760570 6.284228e-02 1.314426e-01 18 45912290 45912456 167 - 1.122 0.951 -0.624
ENSG00000152223 E046 8.1541778 0.0026329156 1.142845e-01 2.117856e-01 18 45913706 45913828 123 - 1.015 0.856 -0.600
ENSG00000152223 E047 8.8935554 0.0284070739 2.998311e-01 4.414145e-01 18 45915511 45915621 111 - 1.035 0.926 -0.404
ENSG00000152223 E048 10.4605323 0.0250742682 1.289201e-02 3.566312e-02 18 45916009 45916206 198 - 1.152 0.853 -1.106
ENSG00000152223 E049 8.8144677 0.0019386701 3.843064e-04 1.714043e-03 18 45916438 45916582 145 - 1.106 0.696 -1.566
ENSG00000152223 E050 2.5121179 0.0061394964 1.207103e-01 2.209787e-01 18 45916583 45917678 1096 - 0.615 0.366 -1.236
ENSG00000152223 E051 9.3486475 0.0022906210 1.571555e-03 5.866416e-03 18 45917679 45917819 141 - 1.114 0.767 -1.305
ENSG00000152223 E052 13.9727642 0.0295597092 1.280853e-02 3.546378e-02 18 45922341 45922600 260 - 1.257 0.974 -1.020
ENSG00000152223 E053 9.7573432 0.0029043639 1.062121e-01 1.999400e-01 18 45923268 45923387 120 - 1.081 0.929 -0.557
ENSG00000152223 E054 12.8198732 0.0033547020 8.957013e-02 1.744648e-01 18 45925738 45925902 165 - 1.187 1.047 -0.505
ENSG00000152223 E055 9.8088402 0.0483692711 5.669346e-02 1.209314e-01 18 45928869 45929009 141 - 1.106 0.858 -0.920
ENSG00000152223 E056 0.1472490 0.0428126144 8.100360e-01   18 45929720 45929884 165 - 0.093 0.000 -13.165
ENSG00000152223 E057 7.3554912 0.0188755270 7.907849e-02 1.580377e-01 18 45930676 45930830 155 - 0.984 0.768 -0.829
ENSG00000152223 E058 6.4034240 0.0148625283 1.748112e-01 2.944586e-01 18 45934809 45934966 158 - 0.926 0.766 -0.620
ENSG00000152223 E059 8.2570659 0.1026293050 4.953615e-01 6.321830e-01 18 45939600 45939755 156 - 1.003 0.898 -0.393
ENSG00000152223 E060 8.6984743 0.0021166151 2.006710e-01 3.270407e-01 18 45943161 45943311 151 - 1.025 0.906 -0.443
ENSG00000152223 E061 7.9918294 0.0022197138 4.534880e-02 1.008321e-01 18 45944005 45944119 115 - 1.015 0.799 -0.821
ENSG00000152223 E062 6.3893833 0.0136379259 4.458675e-02 9.943993e-02 18 45946663 45946768 106 - 0.950 0.696 -0.999
ENSG00000152223 E063 6.6832976 0.0501868250 6.334434e-01 7.481497e-01 18 45948503 45948576 74 - 0.900 0.854 -0.176
ENSG00000152223 E064 9.6156057 0.0033352882 1.520526e-01 2.644807e-01 18 45949484 45949591 108 - 1.063 0.930 -0.492
ENSG00000152223 E065 10.0315465 0.0113543796 7.154948e-03 2.162580e-02 18 45951102 45951238 137 - 1.130 0.829 -1.120
ENSG00000152223 E066 11.9864525 0.0047324816 7.868995e-03 2.345065e-02 18 45952400 45952643 244 - 1.187 0.930 -0.939
ENSG00000152223 E067 22.2043129 0.0008820170 9.661006e-07 8.039747e-06 18 45954394 45955338 945 - 1.467 1.096 -1.303
ENSG00000152223 E068 2.7398067 0.0058573361 6.360661e-02 1.327028e-01 18 45967177 45967329 153 - 0.663 0.366 -1.443