ENSG00000152193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282003 ENSG00000152193 HEK293_OSMI2_2hA HEK293_TMG_2hB OBI1 protein_coding protein_coding 20.79674 5.499196 37.00047 0.5495695 1.2297 2.74802 17.591372 5.336062 30.318642 0.4921068 1.4001222 2.504133 0.89025417 0.9717333 0.8187000 -0.1530333 1.019469e-09 1.183596e-12 FALSE TRUE
MSTRG.8913.2 ENSG00000152193 HEK293_OSMI2_2hA HEK293_TMG_2hB OBI1 protein_coding   20.79674 5.499196 37.00047 0.5495695 1.2297 2.74802 1.934066 0.000000 4.105643 0.0000000 0.2932887 8.684974 0.05695417 0.0000000 0.1117667 0.1117667 1.183596e-12 1.183596e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152193 E001 357.156233 0.0092010209 2.135602e-23 1.972615e-21 13 78614289 78615005 717 - 2.286 2.784 1.661
ENSG00000152193 E002 782.535729 0.0001032025 4.514248e-01 5.923702e-01 13 78615006 78616603 1598 - 2.730 2.816 0.287
ENSG00000152193 E003 313.764798 0.0002740455 8.219328e-10 1.237878e-08 13 78616604 78617122 519 - 2.359 2.256 -0.346
ENSG00000152193 E004 5.146608 0.0033861893 9.463907e-01 9.703568e-01 13 78633340 78633480 141 - 0.656 0.728 0.300
ENSG00000152193 E005 5.579834 0.0029851519 4.464253e-01 5.879110e-01 13 78633481 78633629 149 - 0.668 0.850 0.736
ENSG00000152193 E006 135.450161 0.0009665018 8.954560e-05 4.728550e-04 13 78635110 78635198 89 - 1.999 1.889 -0.368
ENSG00000152193 E007 161.649633 0.0002747320 3.131031e-12 7.091026e-11 13 78638823 78638966 144 - 2.087 1.854 -0.784
ENSG00000152193 E008 124.569215 0.0002756773 3.380880e-13 8.915613e-12 13 78638967 78639071 105 - 1.982 1.673 -1.041
ENSG00000152193 E009 118.409444 0.0016258383 2.311204e-08 2.662354e-07 13 78642122 78642213 92 - 1.953 1.719 -0.790
ENSG00000152193 E010 2.543227 0.0329744071 7.689055e-01 8.506639e-01 13 78643026 78643168 143 - 0.451 0.438 -0.071
ENSG00000152193 E011 120.290826 0.0392279046 1.020023e-02 2.925888e-02 13 78644862 78644997 136 - 1.957 1.753 -0.688
ENSG00000152193 E012 88.510410 0.0596797614 7.527153e-02 1.519669e-01 13 78659049 78659189 141 - 1.821 1.667 -0.521