ENSG00000152127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409645 ENSG00000152127 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5 protein_coding protein_coding 15.77463 11.53654 19.43711 1.068302 0.4126346 0.7520952 12.2518859 10.3100082 13.279895 1.6386535 0.6022628 0.3648856 0.7921458 0.8819667 0.6833333 -0.19863333 9.158721e-02 7.746025e-11 FALSE TRUE
ENST00000481801 ENSG00000152127 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5 protein_coding processed_transcript 15.77463 11.53654 19.43711 1.068302 0.4126346 0.7520952 0.5630468 0.0000000 1.348600 0.0000000 0.2609009 7.0859774 0.0293375 0.0000000 0.0689000 0.06890000 7.746025e-11 7.746025e-11 FALSE FALSE
MSTRG.19256.9 ENSG00000152127 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5 protein_coding   15.77463 11.53654 19.43711 1.068302 0.4126346 0.7520952 1.7378582 0.9408795 2.229523 0.6877794 0.4820535 1.2358569 0.1085708 0.0948000 0.1151667 0.02036667 7.146452e-01 7.746025e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152127 E001 1.632766 0.0088305100 1.536671e-03 5.755486e-03 2 134119942 134119944 3 + 0.517 0.000 -21.072
ENSG00000152127 E002 6.635909 0.0324285917 1.075531e-02 3.057977e-02 2 134119945 134119962 18 + 0.918 0.706 -0.838
ENSG00000152127 E003 11.051997 0.0189077045 8.736921e-05 4.626907e-04 2 134119963 134119982 20 + 1.137 0.820 -1.178
ENSG00000152127 E004 16.792407 0.0154032103 3.881182e-07 3.507505e-06 2 134119983 134120163 181 + 1.317 0.937 -1.369
ENSG00000152127 E005 6.900758 0.0805876514 5.605430e-03 1.756711e-02 2 134120164 134120181 18 + 0.959 0.612 -1.388
ENSG00000152127 E006 19.844204 0.0167344793 1.601907e-09 2.286591e-08 2 134120182 134120291 110 + 1.404 0.910 -1.772
ENSG00000152127 E007 1.554187 0.0475638585 2.020895e-01 3.288094e-01 2 134190107 134190248 142 + 0.426 0.305 -0.712
ENSG00000152127 E008 1.508103 0.0342654485 1.889666e-01 3.124490e-01 2 134250050 134250052 3 + 0.426 0.304 -0.714
ENSG00000152127 E009 4.987577 0.0033976238 2.707659e-03 9.396554e-03 2 134250053 134250145 93 + 0.821 0.549 -1.145
ENSG00000152127 E010 7.063123 0.0101568543 4.899858e-06 3.495099e-05 2 134253095 134253103 9 + 0.989 0.483 -2.102
ENSG00000152127 E011 17.485847 0.0010752747 1.974276e-05 1.226113e-04 2 134253104 134253218 115 + 1.291 1.121 -0.603
ENSG00000152127 E012 0.147249 0.0433826667 7.038264e-01   2 134254072 134254261 190 + 0.082 0.000 -17.612
ENSG00000152127 E013 12.180960 0.0014043321 1.307875e-05 8.452664e-05 2 134254262 134254264 3 + 1.169 0.909 -0.950
ENSG00000152127 E014 119.280710 0.0003880688 1.062306e-29 1.742430e-27 2 134254265 134254644 380 + 2.109 1.918 -0.641
ENSG00000152127 E015 81.412209 0.0003275698 8.548781e-21 6.025078e-19 2 134270386 134270550 165 + 1.944 1.759 -0.622
ENSG00000152127 E016 68.300467 0.0380318278 9.132096e-05 4.811704e-04 2 134317529 134317605 77 + 1.868 1.681 -0.632
ENSG00000152127 E017 59.987755 0.0649657045 2.506605e-03 8.783133e-03 2 134318650 134318739 90 + 1.808 1.637 -0.579
ENSG00000152127 E018 52.685429 0.0293686469 4.555647e-04 1.988832e-03 2 134336217 134336288 72 + 1.741 1.607 -0.457
ENSG00000152127 E019 80.213389 0.0095112422 2.322396e-09 3.218279e-08 2 134338259 134338420 162 + 1.932 1.758 -0.588
ENSG00000152127 E020 92.430917 0.0035911630 8.381532e-08 8.639043e-07 2 134341590 134341759 170 + 1.958 1.914 -0.148
ENSG00000152127 E021 81.806280 0.0177703304 6.673465e-03 2.037433e-02 2 134344930 134345064 135 + 1.887 1.900 0.041
ENSG00000152127 E022 82.411592 0.0107703649 1.722140e-04 8.447369e-04 2 134349805 134349938 134 + 1.903 1.878 -0.083
ENSG00000152127 E023 86.796750 0.0111260696 1.364179e-04 6.876685e-04 2 134362275 134362408 134 + 1.927 1.901 -0.089
ENSG00000152127 E024 96.167031 0.0006064733 5.386235e-12 1.170996e-10 2 134402988 134403137 150 + 1.980 1.929 -0.173
ENSG00000152127 E025 99.804115 0.0056776110 1.580829e-05 1.003496e-04 2 134412869 134413015 147 + 1.979 1.970 -0.031
ENSG00000152127 E026 90.874948 0.0087321224 6.827265e-03 2.077425e-02 2 134422803 134422919 117 + 1.917 1.971 0.179
ENSG00000152127 E027 71.587417 0.0003556940 1.291879e-05 8.361836e-05 2 134428365 134428439 75 + 1.825 1.852 0.092
ENSG00000152127 E028 96.985253 0.0002947626 3.709992e-04 1.662205e-03 2 134441758 134441915 158 + 1.934 2.020 0.288
ENSG00000152127 E029 386.202244 0.0001665456 1.819692e-10 3.070317e-09 2 134448649 134449860 1212 + 2.526 2.628 0.339
ENSG00000152127 E030 2083.053652 0.0118685862 6.450222e-16 2.498927e-14 2 134449861 134454621 4761 + 3.109 3.523 1.377
ENSG00000152127 E031 0.000000       2 134494472 134494527 56 +