ENSG00000152117

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000438378 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene processed_transcript 14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 3.929473 1.5685198 3.5367590 1.56851978 1.7692124 1.1679290 0.28767500 0.11936667 0.31533333 0.19596667 0.454500351 0.001114399 FALSE  
MSTRG.19236.1 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene   14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 2.689605 5.3863969 1.9946039 2.73477617 1.9946039 -1.4286793 0.17601250 0.34593333 0.17143333 -0.17450000 0.466366148 0.001114399 FALSE  
MSTRG.19236.10 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene   14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 1.127340 2.1586103 0.4933396 0.88881511 0.2711201 -2.1071668 0.06996667 0.15590000 0.04406667 -0.11183333 0.462231766 0.001114399 FALSE  
MSTRG.19236.11 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene   14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 1.864712 2.5272388 1.2293495 0.42709919 0.5149606 -1.0336762 0.12761250 0.16896667 0.10710000 -0.06186667 0.448015319 0.001114399 FALSE  
MSTRG.19236.12 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene   14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 1.509189 0.7414152 1.4756035 0.09148131 0.2014843 0.9833669 0.10587083 0.04990000 0.13030000 0.08040000 0.001114399 0.001114399 TRUE  
MSTRG.19236.13 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene   14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 1.414148 0.8829699 1.1075510 0.13043887 0.2593818 0.3236573 0.09852083 0.05956667 0.09783333 0.03826667 0.442380911 0.001114399 FALSE  
MSTRG.19236.4 ENSG00000152117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4BP transcribed_processed_pseudogene   14.49396 14.75487 11.35771 1.18646 0.1520852 -0.3772271 1.335721 0.9414368 0.9149586 0.12261193 0.1248258 -0.0407190 0.09022500 0.06366667 0.08070000 0.01703333 0.637166090 0.001114399 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152117 E001 2.2048312 0.0288296768 4.164716e-01 5.598211e-01 2 131492366 131492395 30 + 0.558 0.433 -0.610
ENSG00000152117 E002 1.1908034 0.0170647409 6.203716e-02 1.300501e-01 2 131492813 131492841 29 + 0.511 0.195 -1.984
ENSG00000152117 E003 10.6979900 0.0973421109 6.563145e-02 1.360955e-01 2 131492842 131493061 220 + 1.203 0.920 -1.032
ENSG00000152117 E004 7.7711579 0.0991528240 5.450456e-02 1.171288e-01 2 131493062 131493075 14 + 1.086 0.778 -1.163
ENSG00000152117 E005 8.3299875 0.0621311540 1.122580e-01 2.088413e-01 2 131493076 131493083 8 + 1.073 0.851 -0.829
ENSG00000152117 E006 8.4708938 0.0455577437 6.957036e-02 1.426473e-01 2 131493084 131493085 2 + 1.086 0.849 -0.883
ENSG00000152117 E007 12.7834326 0.0017733677 1.395609e-03 5.292441e-03 2 131493086 131493093 8 + 1.268 0.991 -0.994
ENSG00000152117 E008 13.8040843 0.0018400561 4.703180e-04 2.046496e-03 2 131493094 131493101 8 + 1.310 1.016 -1.051
ENSG00000152117 E009 16.5978233 0.0011229670 4.918745e-04 2.129388e-03 2 131493102 131493115 14 + 1.376 1.111 -0.934
ENSG00000152117 E010 21.8618486 0.0008930388 4.417262e-05 2.521961e-04 2 131493116 131493140 25 + 1.495 1.220 -0.954
ENSG00000152117 E011 34.2757638 0.0189311562 1.484775e-02 4.014842e-02 2 131497210 131497293 84 + 1.642 1.455 -0.641
ENSG00000152117 E012 38.1270738 0.0097623393 5.688855e-03 1.778820e-02 2 131498867 131498953 87 + 1.681 1.504 -0.604
ENSG00000152117 E013 52.1317820 0.0026761156 5.808662e-04 2.463087e-03 2 131500204 131500346 143 + 1.807 1.647 -0.540
ENSG00000152117 E014 2.7573091 0.0424892363 5.905188e-02 1.250122e-01 2 131500347 131500350 4 + 0.738 0.430 -1.402
ENSG00000152117 E015 0.2214452 0.0372436748 6.515303e-01   2 131500351 131500505 155 + 0.000 0.109 8.831
ENSG00000152117 E016 41.7186676 0.0005957046 1.315834e-04 6.658320e-04 2 131500506 131500581 76 + 1.723 1.541 -0.620
ENSG00000152117 E017 0.6642364 0.0469456101 7.535180e-01 8.394247e-01 2 131500582 131500961 380 + 0.242 0.195 -0.394
ENSG00000152117 E018 54.8418309 0.0004263060 5.108659e-05 2.872467e-04 2 131500962 131501070 109 + 1.826 1.659 -0.568
ENSG00000152117 E019 3.8750582 0.0040549747 1.106246e-01 2.064513e-01 2 131501071 131501180 110 + 0.794 0.584 -0.881
ENSG00000152117 E020 46.1267795 0.0007847683 1.965758e-04 9.493154e-04 2 131501181 131501233 53 + 1.753 1.582 -0.580
ENSG00000152117 E021 1.2889475 0.0102404937 6.059475e-02 1.276336e-01 2 131501234 131501357 124 + 0.510 0.195 -1.979
ENSG00000152117 E022 71.1999418 0.0004094590 5.117442e-06 3.633884e-05 2 131501358 131501508 151 + 1.935 1.768 -0.562
ENSG00000152117 E023 1.7306179 0.0116922705 8.134422e-01 8.817047e-01 2 131501509 131501852 344 + 0.457 0.431 -0.135
ENSG00000152117 E024 15.3135735 0.0012866165 2.592611e-01 3.966493e-01 2 131502455 131502692 238 + 1.241 1.165 -0.269
ENSG00000152117 E025 2.8535653 0.0817730577 8.337108e-01 8.958469e-01 2 131503866 131503962 97 + 0.601 0.579 -0.099
ENSG00000152117 E026 67.7570392 0.0004254668 3.531736e-04 1.592623e-03 2 131506312 131506442 131 + 1.896 1.766 -0.437
ENSG00000152117 E027 1.8737884 0.0093107099 4.075046e-01 5.510741e-01 2 131506443 131506919 477 + 0.510 0.384 -0.656
ENSG00000152117 E028 40.5539721 0.0005938003 1.966372e-03 7.120773e-03 2 131508537 131508608 72 + 1.685 1.538 -0.501
ENSG00000152117 E029 21.6632258 0.0195670399 5.316311e-02 1.147812e-01 2 131508609 131508924 316 + 1.434 1.266 -0.584
ENSG00000152117 E030 32.6899382 0.0007504589 1.885096e-01 3.118621e-01 2 131511715 131512017 303 + 1.439 1.545 0.363
ENSG00000152117 E031 75.8258139 0.0065603483 1.759429e-01 2.959254e-01 2 131515602 131515747 146 + 1.801 1.905 0.348
ENSG00000152117 E032 72.3541483 0.0003395840 3.134163e-01 4.560036e-01 2 131516314 131516404 91 + 1.807 1.872 0.221
ENSG00000152117 E033 70.1526946 0.0035768731 3.487416e-01 4.929715e-01 2 131516857 131516957 101 + 1.794 1.865 0.239
ENSG00000152117 E034 91.2895273 0.0003226534 4.002170e-01 5.439096e-01 2 131517727 131517890 164 + 1.914 1.968 0.184
ENSG00000152117 E035 124.6424088 0.0017241336 2.757957e-02 6.717321e-02 2 131518503 131518708 206 + 2.014 2.121 0.358
ENSG00000152117 E036 188.5332875 0.0006352718 2.261272e-03 8.034193e-03 2 131519050 131519283 234 + 2.191 2.299 0.363
ENSG00000152117 E037 132.5648068 0.0002986019 3.555394e-04 1.601500e-03 2 131519535 131519666 132 + 2.020 2.157 0.458
ENSG00000152117 E038 5.9850510 0.0036978528 6.529919e-01 7.635967e-01 2 131519814 131519942 129 + 0.843 0.806 -0.146
ENSG00000152117 E039 521.4332895 0.0030977912 1.412267e-09 2.037388e-08 2 131520097 131521573 1477 + 2.586 2.766 0.600