ENSG00000152076

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310463 ENSG00000152076 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC74B protein_coding protein_coding 7.964755 11.84973 6.223298 0.6600666 0.5035262 -0.9280033 1.2090313 2.705088 0.6100221 0.3247246 0.09667395 -2.1306073 0.14312083 0.2314333 0.09836667 -0.133066667 0.01919799 0.01919799 FALSE TRUE
ENST00000409943 ENSG00000152076 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC74B protein_coding protein_coding 7.964755 11.84973 6.223298 0.6600666 0.5035262 -0.9280033 2.3336911 3.635061 1.8611995 0.2705974 0.26139088 -0.9619796 0.28967500 0.3066667 0.29720000 -0.009466667 0.94389196 0.01919799 FALSE TRUE
ENST00000496704 ENSG00000152076 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC74B protein_coding retained_intron 7.964755 11.84973 6.223298 0.6600666 0.5035262 -0.9280033 1.2122679 0.886422 0.9706483 0.1068897 0.05787372 0.1295578 0.16972500 0.0763000 0.15796667 0.081666667 0.03050638 0.01919799 FALSE TRUE
MSTRG.19195.5 ENSG00000152076 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC74B protein_coding   7.964755 11.84973 6.223298 0.6600666 0.5035262 -0.9280033 1.5040944 2.366613 1.2741880 0.4776912 0.07400863 -0.8880504 0.18429167 0.1965667 0.20560000 0.009033333 0.93387138 0.01919799 FALSE TRUE
MSTRG.19195.6 ENSG00000152076 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC74B protein_coding   7.964755 11.84973 6.223298 0.6600666 0.5035262 -0.9280033 0.8397437 1.479097 0.7386794 0.1748666 0.31417147 -0.9920176 0.09837917 0.1240667 0.11903333 -0.005033333 0.89992563 0.01919799 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152076 E001 0.3697384 0.0251211144 5.580080e-01 0.6863197607 2 130139287 130139288 2 - 0.001 0.152 8.278
ENSG00000152076 E002 2.1628978 0.2529587570 7.197980e-01 0.8145388197 2 130139289 130139325 37 - 0.400 0.470 0.365
ENSG00000152076 E003 2.9712878 0.0570053599 9.909872e-01 0.9984924408 2 130139326 130139334 9 - 0.547 0.549 0.009
ENSG00000152076 E004 31.0767007 0.0094220922 1.442631e-01 0.2538071294 2 130139335 130139426 92 - 1.365 1.484 0.410
ENSG00000152076 E005 111.9178792 0.0004070693 9.998798e-02 0.1904737372 2 130139427 130139690 264 - 1.956 2.011 0.184
ENSG00000152076 E006 1.3619106 0.1480928592 4.045433e-01 0.5482522658 2 130139691 130139890 200 - 0.480 0.306 -0.981
ENSG00000152076 E007 66.0655554 0.0007219256 5.605989e-01 0.6885797003 2 130139891 130139947 57 - 1.748 1.772 0.079
ENSG00000152076 E008 62.4612116 0.0005047382 1.774531e-01 0.2979444430 2 130140023 130140096 74 - 1.699 1.761 0.210
ENSG00000152076 E009 71.4591362 0.0003743870 2.883627e-02 0.0696786349 2 130140179 130140282 104 - 1.728 1.825 0.327
ENSG00000152076 E010 68.7856858 0.0014051174 5.586415e-02 0.1194556770 2 130140283 130140371 89 - 1.720 1.811 0.306
ENSG00000152076 E011 11.4487359 0.0377393379 1.366845e-02 0.0374689593 2 130140372 130141016 645 - 1.247 0.926 -1.164
ENSG00000152076 E012 4.3390546 0.0430493853 5.781067e-03 0.0180363913 2 130141017 130141157 141 - 0.958 0.519 -1.812
ENSG00000152076 E013 90.0320779 0.0010923420 7.955055e-01 0.8694089691 2 130141158 130141296 139 - 1.915 1.902 -0.046
ENSG00000152076 E014 15.9059044 0.0012031437 7.552434e-05 0.0004067738 2 130141297 130142132 836 - 1.393 1.052 -1.206
ENSG00000152076 E015 49.3999097 0.0013159501 3.098860e-01 0.4522322400 2 130142133 130142183 51 - 1.690 1.631 -0.201
ENSG00000152076 E016 12.8048089 0.0060776515 3.602720e-01 0.5045906725 2 130142184 130142187 4 - 1.004 1.099 0.349
ENSG00000152076 E017 29.8285870 0.0008867724 6.324727e-02 0.1321204771 2 130142188 130142353 166 - 1.326 1.458 0.456
ENSG00000152076 E018 12.0253653 0.0015681889 8.550650e-01 0.9103632388 2 130142354 130142381 28 - 1.045 1.060 0.056
ENSG00000152076 E019 6.3504249 0.0405084835 1.621575e-02 0.0432004242 2 130142382 130142779 398 - 1.045 0.682 -1.406
ENSG00000152076 E020 5.4260215 0.0328967223 4.227783e-03 0.0137795441 2 130142780 130143210 431 - 1.025 0.597 -1.700
ENSG00000152076 E021 1.3941639 0.1451710039 1.892785e-01 0.3128281834 2 130143211 130143268 58 - 0.547 0.262 -1.603
ENSG00000152076 E022 45.4446086 0.0005293855 4.239590e-02 0.0954379928 2 130143269 130143313 45 - 1.694 1.581 -0.385
ENSG00000152076 E023 1.4048591 0.0231191388 6.417417e-01 0.7547134451 2 130144372 130144474 103 - 0.400 0.312 -0.527
ENSG00000152076 E024 17.3925938 0.0013490105 3.674769e-01 0.5118624514 2 130144621 130144746 126 - 1.271 1.190 -0.288
ENSG00000152076 E025 43.4216797 0.0104419287 4.318845e-01 0.5743813745 2 130144747 130145134 388 - 1.632 1.573 -0.202