ENSG00000152061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251507 ENSG00000152061 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGAP1L protein_coding protein_coding 4.454008 2.69062 6.09222 0.3865177 0.2875016 1.176044 1.1949457 0.7664819 2.0105807 0.1709123 0.19608646 1.3797457 0.25927500 0.2809667 0.33060000 0.04963333 0.756618439 0.002816041 FALSE TRUE
ENST00000367690 ENSG00000152061 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGAP1L protein_coding protein_coding 4.454008 2.69062 6.09222 0.3865177 0.2875016 1.176044 0.2761189 0.3538476 0.1417418 0.1254605 0.02293023 -1.2617160 0.08023750 0.1265333 0.02320000 -0.10333333 0.002816041 0.002816041 FALSE TRUE
ENST00000485114 ENSG00000152061 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGAP1L protein_coding protein_coding 4.454008 2.69062 6.09222 0.3865177 0.2875016 1.176044 0.4176950 0.8398238 0.4221347 0.1565099 0.21717940 -0.9756827 0.14809167 0.3157667 0.06646667 -0.24930000 0.153533231 0.002816041   FALSE
ENST00000529474 ENSG00000152061 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGAP1L protein_coding processed_transcript 4.454008 2.69062 6.09222 0.3865177 0.2875016 1.176044 0.4175094 0.2773759 0.4172466 0.1657221 0.23155052 0.5721301 0.09475417 0.0905000 0.06513333 -0.02536667 0.926650642 0.002816041   FALSE
ENST00000681986 ENSG00000152061 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGAP1L protein_coding protein_coding 4.454008 2.69062 6.09222 0.3865177 0.2875016 1.176044 1.5338810 0.2372285 2.2845479 0.1206805 0.17388597 3.2142929 0.28522500 0.1036667 0.37933333 0.27566667 0.205099651 0.002816041 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152061 E001 0.1515154 0.0428886192 1.000000e+00   1 174159410 174159472 63 + 0.066 0.000 -7.895
ENSG00000152061 E002 1.1835302 0.1136844228 5.631004e-01 6.906046e-01 1 174159473 174159501 29 + 0.334 0.214 -0.858
ENSG00000152061 E003 1.4865611 0.1821883202 4.385219e-01 5.804037e-01 1 174159502 174159516 15 + 0.396 0.214 -1.229
ENSG00000152061 E004 1.6338101 0.0242595296 2.856450e-01 4.260052e-01 1 174159517 174159519 3 + 0.423 0.215 -1.366
ENSG00000152061 E005 7.7863726 0.0021636725 2.824687e-04 1.308383e-03 1 174159520 174159580 61 + 0.966 0.359 -2.686
ENSG00000152061 E006 6.7447928 0.0025320730 1.251778e-03 4.815726e-03 1 174159581 174159589 9 + 0.908 0.359 -2.468
ENSG00000152061 E007 8.8967363 0.0020142416 2.068535e-03 7.436857e-03 1 174159590 174159657 68 + 1.003 0.552 -1.823
ENSG00000152061 E008 10.8313857 0.0093473149 5.357854e-03 1.690391e-02 1 174219125 174219163 39 + 1.070 0.686 -1.478
ENSG00000152061 E009 7.4175752 0.0039765844 1.319852e-02 3.637134e-02 1 174219164 174219184 21 + 0.926 0.552 -1.534
ENSG00000152061 E010 10.3973722 0.0016997632 6.854047e-01 7.881605e-01 1 174219185 174219247 63 + 0.996 0.970 -0.096
ENSG00000152061 E011 9.7538484 0.0017611631 4.355056e-01 5.777434e-01 1 174219248 174219295 48 + 0.982 0.906 -0.282
ENSG00000152061 E012 0.0000000       1 174220712 174220971 260 +      
ENSG00000152061 E013 26.4837607 0.0007029101 1.770432e-01 2.973958e-01 1 174220972 174221164 193 + 1.391 1.306 -0.295
ENSG00000152061 E014 27.1866658 0.0007445876 6.775352e-01 7.822262e-01 1 174231145 174231355 211 + 1.370 1.426 0.193
ENSG00000152061 E015 1.3921762 0.0825179998 9.380441e-01 9.650625e-01 1 174238822 174238949 128 + 0.333 0.359 0.155
ENSG00000152061 E016 26.3559142 0.0007455620 7.249824e-01 8.183389e-01 1 174241483 174241657 175 + 1.373 1.370 -0.011
ENSG00000152061 E017 5.9733276 0.0027465411 1.289396e-02 3.566748e-02 1 174242982 174243179 198 + 0.681 1.026 1.341
ENSG00000152061 E018 29.6612643 0.0309732181 8.337457e-04 3.379490e-03 1 174244298 174246346 2049 + 1.297 1.685 1.334
ENSG00000152061 E019 21.6280168 0.0008776918 2.732389e-01 4.122510e-01 1 174250475 174250632 158 + 1.304 1.231 -0.256
ENSG00000152061 E020 0.2966881 0.0290785164 1.000000e+00   1 174252444 174252479 36 + 0.124 0.000 -11.258
ENSG00000152061 E021 19.3196537 0.0009889453 1.980297e-02 5.106667e-02 1 174252480 174252590 111 + 1.282 1.076 -0.736
ENSG00000152061 E022 14.3308907 0.0012787341 3.043795e-02 7.282159e-02 1 174272414 174272480 67 + 1.162 0.939 -0.814
ENSG00000152061 E023 0.0000000       1 174275100 174275189 90 +      
ENSG00000152061 E024 23.5026128 0.0008170247 2.255829e-01 3.571086e-01 1 174275833 174275935 103 + 1.342 1.263 -0.276
ENSG00000152061 E025 34.9395444 0.0006496459 7.355500e-01 8.262932e-01 1 174278613 174278779 167 + 1.480 1.528 0.162
ENSG00000152061 E026 33.9919958 0.0006823077 4.771400e-01 6.157544e-01 1 174304986 174305127 142 + 1.463 1.536 0.249
ENSG00000152061 E027 0.0000000       1 174365230 174365309 80 +      
ENSG00000152061 E028 24.8646950 0.0013598658 2.099154e-01 3.384410e-01 1 174370979 174371072 94 + 1.315 1.436 0.421
ENSG00000152061 E029 27.1981635 0.0346574065 3.920881e-01 5.360306e-01 1 174393995 174394145 151 + 1.348 1.470 0.422
ENSG00000152061 E030 7.6542538 0.0149806077 3.494211e-13 9.195273e-12 1 174544844 174545911 1068 + 0.450 1.378 3.655
ENSG00000152061 E031 0.0000000       1 174547837 174548561 725 +      
ENSG00000152061 E032 8.1662607 0.0042267274 7.724687e-01 8.531362e-01 1 174637375 174637377 3 + 0.881 0.940 0.222
ENSG00000152061 E033 18.0464790 0.0093262551 2.202004e-01 3.506721e-01 1 174637378 174637488 111 + 1.177 1.319 0.500
ENSG00000152061 E034 15.1320161 0.0013724620 3.404658e-01 4.844142e-01 1 174683522 174683596 75 + 1.116 1.231 0.412
ENSG00000152061 E035 19.1517069 0.0011212200 7.581660e-01 8.428186e-01 1 174699525 174699650 126 + 1.227 1.278 0.181
ENSG00000152061 E036 0.1472490 0.0427521501 1.000000e+00   1 174700413 174700524 112 + 0.066 0.000 -10.231
ENSG00000152061 E037 0.1472490 0.0427521501 1.000000e+00   1 174700525 174700730 206 + 0.066 0.000 -10.231
ENSG00000152061 E038 0.0000000       1 174700731 174700746 16 +      
ENSG00000152061 E039 0.0000000       1 174700747 174700865 119 +      
ENSG00000152061 E040 0.0000000       1 174701020 174701021 2 +      
ENSG00000152061 E041 0.0000000       1 174701022 174701122 101 +      
ENSG00000152061 E042 0.0000000       1 174701123 174701145 23 +      
ENSG00000152061 E043 18.7936192 0.0010003685 3.773576e-01 5.216900e-01 1 174702113 174702256 144 + 1.205 1.306 0.357
ENSG00000152061 E044 0.2214452 0.0412055113 1.180235e-01   1 174705201 174705750 550 + 0.000 0.216 11.849
ENSG00000152061 E045 10.2649811 0.0092239690 2.877319e-01 4.282477e-01 1 174752313 174752354 42 + 0.950 1.098 0.544
ENSG00000152061 E046 0.8888167 0.0155042564 1.307091e-01 2.351408e-01 1 174799932 174800500 569 + 0.175 0.465 1.954
ENSG00000152061 E047 19.9746969 0.0018574552 9.772701e-01 9.898412e-01 1 174811832 174811960 129 + 1.251 1.278 0.093
ENSG00000152061 E048 0.0000000       1 174874458 174874470 13 +      
ENSG00000152061 E049 0.0000000       1 174874471 174874506 36 +      
ENSG00000152061 E050 0.0000000       1 174875546 174875713 168 +      
ENSG00000152061 E051 0.1472490 0.0427521501 1.000000e+00   1 174877392 174877439 48 + 0.066 0.000 -10.231
ENSG00000152061 E052 0.0000000       1 174877440 174877605 166 +      
ENSG00000152061 E053 19.5253991 0.0012201512 4.902214e-01 6.275659e-01 1 174957457 174957549 93 + 1.222 1.306 0.295
ENSG00000152061 E054 10.2241653 0.0018800954 1.125734e-04 5.797031e-04 1 174957891 174958173 283 + 0.852 1.278 1.555
ENSG00000152061 E055 0.1472490 0.0427521501 1.000000e+00   1 174958174 174958187 14 + 0.066 0.000 -10.231
ENSG00000152061 E056 0.0000000       1 174964768 174964958 191 +      
ENSG00000152061 E057 0.0000000       1 174964959 174964985 27 +      
ENSG00000152061 E058 13.6491388 0.0012900338 4.504867e-04 1.968478e-03 1 174969277 174969387 111 + 1.167 0.740 -1.609
ENSG00000152061 E059 0.0000000       1 174976029 174976077 49 +      
ENSG00000152061 E060 13.4836914 0.0014940969 1.744589e-03 6.422976e-03 1 174976078 174976182 105 + 1.158 0.788 -1.381
ENSG00000152061 E061 8.8540854 0.0243697682 5.807571e-03 1.810715e-02 1 174978807 174978890 84 + 1.003 0.552 -1.821
ENSG00000152061 E062 7.4847221 0.0051880518 8.804892e-02 1.721567e-01 1 174982834 174982905 72 + 0.917 0.685 -0.917
ENSG00000152061 E063 10.6747967 0.0076802065 1.309274e-02 3.612291e-02 1 174988641 174988838 198 + 1.063 0.739 -1.235
ENSG00000152061 E064 129.3050323 0.0004176237 4.111817e-10 6.544328e-09 1 174989849 174993586 3738 + 2.086 1.870 -0.726
ENSG00000152061 E065 95.5672169 0.0056912973 1.581644e-07 1.545959e-06 1 174993587 174995308 1722 + 1.833 2.110 0.933