ENSG00000151923

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369093 ENSG00000151923 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAL1 protein_coding protein_coding 58.72739 41.30386 74.27561 3.61396 2.095999 0.846457 3.584564 3.329799 5.1181362 0.3412518 0.0420146 0.6186735 0.06321667 0.08043333 0.069033333 -0.011400000 0.442850750 1.919214e-13 FALSE  
ENST00000463089 ENSG00000151923 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAL1 protein_coding processed_transcript 58.72739 41.30386 74.27561 3.61396 2.095999 0.846457 1.066864 2.447047 0.4246191 0.6229604 0.2134914 -2.4991020 0.02276250 0.06106667 0.005833333 -0.055233333 0.073955583 1.919214e-13    
ENST00000470781 ENSG00000151923 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAL1 protein_coding retained_intron 58.72739 41.30386 74.27561 3.61396 2.095999 0.846457 6.745795 2.942887 7.9167220 0.2294799 0.0721860 1.4245984 0.11635000 0.07136667 0.106800000 0.035433333 0.001774796 1.919214e-13 TRUE  
MSTRG.4726.14 ENSG00000151923 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAL1 protein_coding   58.72739 41.30386 74.27561 3.61396 2.095999 0.846457 3.456162 4.242336 7.2588651 0.5091137 1.1543377 0.7734746 0.06563750 0.10220000 0.097133333 -0.005066667 0.900340651 1.919214e-13 FALSE  
MSTRG.4726.16 ENSG00000151923 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAL1 protein_coding   58.72739 41.30386 74.27561 3.61396 2.095999 0.846457 30.131906 22.377192 32.7916563 2.1251149 1.3520470 0.5510951 0.50810000 0.54113333 0.441400000 -0.099733333 0.003115209 1.919214e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151923 E001 145.1113827 0.0003253593 2.246528e-11 4.419960e-10 10 119571802 119573464 1663 - 2.066 2.265 0.665
ENSG00000151923 E002 412.3704676 0.0001614441 4.834793e-17 2.158114e-15 10 119573465 119575218 1754 - 2.675 2.517 -0.527
ENSG00000151923 E003 106.5138384 0.0002940954 3.345819e-10 5.399569e-09 10 119575219 119575398 180 - 2.113 1.880 -0.781
ENSG00000151923 E004 41.8272548 0.0076946757 6.716611e-01 7.778508e-01 10 119575399 119575411 13 - 1.617 1.636 0.066
ENSG00000151923 E005 41.2283896 0.0064646334 2.771218e-01 4.166422e-01 10 119575412 119575424 13 - 1.592 1.656 0.217
ENSG00000151923 E006 64.3163624 0.0006480226 1.057100e-02 3.013988e-02 10 119575425 119575473 49 - 1.763 1.875 0.377
ENSG00000151923 E007 56.1682130 0.0004975383 3.625261e-04 1.628865e-03 10 119575474 119575491 18 - 1.680 1.846 0.560
ENSG00000151923 E008 590.6933877 0.0001672845 2.038185e-24 2.108837e-22 10 119575492 119575791 300 - 2.700 2.851 0.504
ENSG00000151923 E009 549.5625289 0.0004794019 5.233512e-06 3.707273e-05 10 119576611 119576750 140 - 2.705 2.784 0.263
ENSG00000151923 E010 31.0123307 0.0011358889 1.239322e-01 2.255735e-01 10 119576751 119576775 25 - 1.543 1.441 -0.351
ENSG00000151923 E011 41.7473998 0.0020110638 9.636770e-03 2.787305e-02 10 119576776 119576846 71 - 1.689 1.533 -0.533
ENSG00000151923 E012 43.0284301 0.0101671735 1.728448e-02 4.557465e-02 10 119576847 119576905 59 - 1.709 1.532 -0.603
ENSG00000151923 E013 44.0973335 0.0137101569 4.664786e-03 1.499703e-02 10 119576906 119577079 174 - 1.739 1.509 -0.783
ENSG00000151923 E014 291.3056739 0.0002136692 9.011066e-02 1.753011e-01 10 119577080 119577117 38 - 2.450 2.484 0.114
ENSG00000151923 E015 465.6639053 0.0001234960 1.716571e-03 6.334104e-03 10 119577118 119577203 86 - 2.646 2.696 0.167
ENSG00000151923 E016 0.9963223 0.0126183620 1.541720e-03 5.770963e-03 10 119577204 119577214 11 - 0.000 0.538 11.394
ENSG00000151923 E017 330.1264992 0.0001647881 3.002643e-02 7.201076e-02 10 119577451 119577474 24 - 2.502 2.543 0.137
ENSG00000151923 E018 396.6396548 0.0001822832 1.017047e-01 1.930955e-01 10 119577475 119577535 61 - 2.587 2.615 0.092
ENSG00000151923 E019 469.6338833 0.0002060212 3.389873e-01 4.828836e-01 10 119577641 119577736 96 - 2.665 2.679 0.046
ENSG00000151923 E020 282.9429380 0.0002071360 2.540539e-01 3.906836e-01 10 119578726 119578746 21 - 2.442 2.464 0.074
ENSG00000151923 E021 280.6439362 0.0001674740 5.831830e-01 7.073503e-01 10 119578747 119578766 20 - 2.445 2.454 0.032
ENSG00000151923 E022 342.1833420 0.0001729938 2.338317e-01 3.669360e-01 10 119578767 119578834 68 - 2.545 2.519 -0.087
ENSG00000151923 E023 6.0676634 0.0027176316 1.663280e-02 4.412842e-02 10 119578835 119578940 106 - 0.956 0.631 -1.294
ENSG00000151923 E024 303.0958986 0.0012315358 4.156497e-01 5.590198e-01 10 119579935 119580010 76 - 2.492 2.464 -0.092
ENSG00000151923 E025 34.7377656 0.0041429235 1.614844e-11 3.249048e-10 10 119580011 119580470 460 - 1.707 1.206 -1.729
ENSG00000151923 E026 21.6309199 0.0009001609 3.328182e-01 4.765011e-01 10 119580471 119580538 68 - 1.381 1.306 -0.261
ENSG00000151923 E027 10.8952260 0.0015600282 2.495984e-01 3.854453e-01 10 119580539 119580777 239 - 1.120 1.000 -0.435
ENSG00000151923 E028 9.0646278 0.0045984236 6.163416e-02 1.293727e-01 10 119580778 119580846 69 - 1.075 0.854 -0.824
ENSG00000151923 E029 17.5034712 0.0010572014 4.133315e-08 4.534917e-07 10 119581733 119581921 189 - 1.417 0.901 -1.852
ENSG00000151923 E030 275.5477005 0.0002211709 6.366650e-01 7.506256e-01 10 119581922 119582009 88 - 2.446 2.433 -0.044
ENSG00000151923 E031 257.3475711 0.0012697757 2.355975e-01 3.690863e-01 10 119582169 119582223 55 - 2.426 2.391 -0.117
ENSG00000151923 E032 250.6120092 0.0002021504 8.967998e-03 2.619952e-02 10 119582459 119582530 72 - 2.426 2.363 -0.210
ENSG00000151923 E033 194.3285919 0.0002281932 8.928556e-03 2.610055e-02 10 119582531 119582557 27 - 2.319 2.248 -0.237
ENSG00000151923 E034 119.0628189 0.0033574193 6.228459e-02 1.304850e-01 10 119582558 119582608 51 - 2.113 2.030 -0.279
ENSG00000151923 E035 154.2276320 0.0002319155 7.174108e-02 1.462450e-01 10 119588152 119588166 15 - 2.214 2.160 -0.183
ENSG00000151923 E036 197.8655651 0.0002216796 8.007522e-03 2.379721e-02 10 119588167 119588248 82 - 2.327 2.255 -0.239
ENSG00000151923 E037 2.1247743 0.0814336397 8.621127e-02 1.693396e-01 10 119588326 119588357 32 - 0.614 0.259 -1.934
ENSG00000151923 E038 3.9068605 0.0991929200 7.653781e-01 8.481632e-01 10 119591066 119591225 160 - 0.713 0.634 -0.331
ENSG00000151923 E039 7.9540632 0.0021019244 9.829692e-02 1.879291e-01 10 119591976 119592113 138 - 1.024 0.828 -0.743
ENSG00000151923 E040 3.3654482 0.0092459314 4.376714e-02 9.796258e-02 10 119592255 119592296 42 - 0.753 0.421 -1.511
ENSG00000151923 E041 3.8761921 0.0043897930 3.432871e-01 4.873303e-01 10 119593448 119593451 4 - 0.733 0.587 -0.619
ENSG00000151923 E042 31.4575551 0.0006597357 3.907516e-02 8.933519e-02 10 119593452 119593477 26 - 1.562 1.428 -0.461
ENSG00000151923 E043 26.7384911 0.0014544978 2.320953e-02 5.818087e-02 10 119593478 119593513 36 - 1.503 1.340 -0.563
ENSG00000151923 E044 307.3962598 0.0061357077 3.685502e-02 8.519085e-02 10 119596434 119598185 1752 - 2.526 2.425 -0.338