ENSG00000151892

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355422 ENSG00000151892 HEK293_OSMI2_2hA HEK293_TMG_2hB GFRA1 protein_coding protein_coding 0.9637396 0.87292 1.571165 0.125915 0.08457424 0.8406334 0.09301136 0.00000000 0.24259497 0.00000000 0.08778158 4.65875399 0.08087917 0.00000000 0.14953333 0.14953333 0.008258468 0.008258468 FALSE TRUE
ENST00000369236 ENSG00000151892 HEK293_OSMI2_2hA HEK293_TMG_2hB GFRA1 protein_coding protein_coding 0.9637396 0.87292 1.571165 0.125915 0.08457424 0.8406334 0.48710806 0.64011423 0.57685715 0.04287091 0.04999121 -0.14768386 0.55914167 0.75243333 0.37246667 -0.37996667 0.015128523 0.008258468 FALSE TRUE
ENST00000439649 ENSG00000151892 HEK293_OSMI2_2hA HEK293_TMG_2hB GFRA1 protein_coding protein_coding 0.9637396 0.87292 1.571165 0.125915 0.08457424 0.8406334 0.05270795 0.00000000 0.14014280 0.00000000 0.07214595 3.90826338 0.04800000 0.00000000 0.09443333 0.09443333 0.333187607 0.008258468 FALSE TRUE
ENST00000682743 ENSG00000151892 HEK293_OSMI2_2hA HEK293_TMG_2hB GFRA1 protein_coding protein_coding 0.9637396 0.87292 1.571165 0.125915 0.08457424 0.8406334 0.07189188 0.06525859 0.06610482 0.01983997 0.01367759 0.01613167 0.09137500 0.07526667 0.04203333 -0.03323333 0.670184191 0.008258468 FALSE TRUE
ENST00000684105 ENSG00000151892 HEK293_OSMI2_2hA HEK293_TMG_2hB GFRA1 protein_coding protein_coding 0.9637396 0.87292 1.571165 0.125915 0.08457424 0.8406334 0.13747410 0.12705224 0.44423924 0.09464104 0.08225925 1.72872644 0.12911667 0.12453333 0.27903333 0.15450000 0.421870626 0.008258468 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151892 E001 101.2046907 0.0005833557 3.889218e-09 5.168717e-08 10 116056925 116061281 4357 - 1.933 2.083 0.504
ENSG00000151892 E002 46.6379838 0.0203520517 2.363975e-02 5.906881e-02 10 116061282 116063862 2581 - 1.763 1.565 -0.674
ENSG00000151892 E003 4.1885870 0.0143370980 6.917408e-02 1.420023e-01 10 116063863 116063910 48 - 0.836 0.548 -1.206
ENSG00000151892 E004 6.2933114 0.0151738378 1.828133e-01 3.047269e-01 10 116063911 116064210 300 - 0.949 0.756 -0.747
ENSG00000151892 E005 3.8802695 0.0043485516 7.059533e-01 8.042185e-01 10 116064211 116064354 144 - 0.731 0.665 -0.276
ENSG00000151892 E006 3.6190704 0.0083008934 5.317468e-01 6.641394e-01 10 116064355 116064397 43 - 0.731 0.628 -0.431
ENSG00000151892 E007 8.6303261 0.0020566896 9.870483e-01 9.959489e-01 10 116064398 116064544 147 - 1.003 0.986 -0.060
ENSG00000151892 E008 7.7276661 0.0026584316 6.857825e-01 7.884274e-01 10 116065573 116065626 54 - 0.977 0.916 -0.226
ENSG00000151892 E009 0.0000000       10 116083710 116083791 82 -      
ENSG00000151892 E010 12.9104990 0.0015167634 5.230516e-01 6.567991e-01 10 116089741 116089922 182 - 1.185 1.112 -0.261
ENSG00000151892 E011 13.1582695 0.0021771794 5.562505e-01 6.849305e-01 10 116093702 116093836 135 - 1.142 1.179 0.134
ENSG00000151892 E012 11.2341275 0.0104590450 9.853118e-02 1.882494e-01 10 116096655 116096764 110 - 1.015 1.176 0.583
ENSG00000151892 E013 16.8041089 0.0012398817 2.180548e-01 3.480769e-01 10 116125221 116125557 337 - 1.313 1.200 -0.400
ENSG00000151892 E014 0.2987644 0.0290785164 2.865190e-01   10 116211631 116211645 15 - 0.200 0.000 -11.161
ENSG00000151892 E015 0.0000000       10 116255634 116255795 162 -      
ENSG00000151892 E016 8.6013478 0.0019721306 2.608164e-02 6.411088e-02 10 116269503 116269586 84 - 1.093 0.832 -0.975
ENSG00000151892 E017 11.3843995 0.0016653215 7.265469e-01 8.195326e-01 10 116270822 116271115 294 - 1.123 1.074 -0.176
ENSG00000151892 E018 7.9169216 0.0121963286 3.122841e-01 4.548245e-01 10 116271990 116272275 286 - 1.015 0.876 -0.520
ENSG00000151892 E019 0.0000000       10 116272276 116272278 3 -      
ENSG00000151892 E020 0.0000000       10 116272279 116272282 4 -      
ENSG00000151892 E021 0.6664265 0.0178391957 8.014760e-01 8.735124e-01 10 116272561 116272643 83 - 0.200 0.237 0.311
ENSG00000151892 E022 0.3686942 0.0305675918 8.481416e-01 9.057276e-01 10 116272861 116272867 7 - 0.111 0.135 0.313
ENSG00000151892 E023 1.3328556 0.0099451124 3.449517e-02 8.070400e-02 10 116272868 116273009 142 - 0.523 0.134 -2.691
ENSG00000151892 E024 0.2966881 0.0294647499 2.863816e-01   10 116273010 116273033 24 - 0.200 0.000 -11.159
ENSG00000151892 E025 0.2966881 0.0294647499 2.863816e-01   10 116273034 116273152 119 - 0.200 0.000 -11.159
ENSG00000151892 E026 1.2438831 0.1423833473 1.134619e-01 2.105743e-01 10 116273163 116273206 44 - 0.483 0.135 -2.478
ENSG00000151892 E027 0.6998377 0.0180334775 7.973199e-01 8.706688e-01 10 116273207 116273284 78 - 0.200 0.237 0.312
ENSG00000151892 E028 1.3651183 0.0102373003 2.894317e-01 4.301086e-01 10 116273285 116273608 324 - 0.273 0.449 1.048
ENSG00000151892 E029 0.0000000       10 116274225 116274234 10 -      
ENSG00000151892 E030 0.0000000       10 116274235 116274389 155 -      
ENSG00000151892 E031 0.0000000       10 116274390 116274419 30 -      
ENSG00000151892 E032 0.0000000       10 116276180 116276391 212 -      
ENSG00000151892 E033 0.2214452 0.0466120235 3.764518e-01   10 116276745 116276803 59 - 0.000 0.135 9.840