ENSG00000151881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397080 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding protein_coding 5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 0.88449870 0.55386925 1.3329669 0.47463008 0.14565549 1.251991 0.20147083 0.27563333 0.12936667 -0.14626667 9.343026e-01 2.561773e-11 FALSE TRUE
ENST00000500337 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding protein_coding 5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 0.05677538 0.11034253 0.0000000 0.05561123 0.00000000 -3.589075 0.05211667 0.06506667 0.00000000 -0.06506667 5.253185e-04 2.561773e-11 FALSE TRUE
ENST00000506860 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding protein_coding 5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 1.06126289 0.00000000 2.2964820 0.00000000 0.08158603 7.849550 0.15958750 0.00000000 0.22173333 0.22173333 2.561773e-11 2.561773e-11 FALSE FALSE
ENST00000510130 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding protein_coding 5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 0.68729124 0.03972996 0.5157517 0.03972996 0.51575166 3.402194 0.08054583 0.02876667 0.05203333 0.02326667 8.264506e-01 2.561773e-11 FALSE FALSE
ENST00000512085 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding protein_coding 5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 1.26643328 0.79032651 3.0222321 0.14679625 0.46861217 1.921720 0.30714167 0.58556667 0.29093333 -0.29463333 2.462024e-01 2.561773e-11 FALSE TRUE
MSTRG.26137.5 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding   5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 0.89606740 0.00000000 1.4389371 0.00000000 0.43967898 7.178851 0.09092917 0.00000000 0.13830000 0.13830000 2.341731e-03 2.561773e-11 FALSE TRUE
MSTRG.26137.9 ENSG00000151881 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM267 protein_coding   5.546321 1.535569 10.35367 0.4086511 0.2819062 2.745326 0.54780146 0.04130060 1.4545249 0.04130060 0.22158461 4.835313 0.06146667 0.04496667 0.14016667 0.09520000 2.278002e-01 2.561773e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151881 E001 19.427383 0.0949144890 8.151608e-02 1.619219e-01 5 43444252 43445237 986 - 1.122 1.522 1.399
ENSG00000151881 E002 56.094812 0.0004606275 2.978368e-10 4.850347e-09 5 43445238 43445892 655 - 1.612 1.906 0.992
ENSG00000151881 E003 14.765176 0.0013049234 2.881926e-03 9.916490e-03 5 43445893 43445978 86 - 1.059 1.335 0.980
ENSG00000151881 E004 11.078716 0.0148689830 5.455589e-03 1.716938e-02 5 43445979 43446130 152 - 0.929 1.239 1.124
ENSG00000151881 E005 15.468040 0.0012423610 3.751040e-02 8.642411e-02 5 43446131 43446197 67 - 1.115 1.310 0.690
ENSG00000151881 E006 28.348160 0.0008037562 5.036218e-01 6.395947e-01 5 43446198 43446271 74 - 1.405 1.461 0.193
ENSG00000151881 E007 31.233559 0.0006728502 5.498070e-01 6.795005e-01 5 43446272 43446341 70 - 1.466 1.433 -0.115
ENSG00000151881 E008 25.733510 0.0008158870 2.470331e-01 3.824410e-01 5 43446342 43446379 38 - 1.393 1.310 -0.288
ENSG00000151881 E009 57.835499 0.0005073510 1.920096e-04 9.296815e-04 5 43446380 43446557 178 - 1.758 1.566 -0.654
ENSG00000151881 E010 74.677257 0.0061688983 1.509234e-07 1.480836e-06 5 43453658 43454043 386 - 1.886 1.577 -1.044
ENSG00000151881 E011 1.973259 0.0357035560 5.493740e-01 6.791116e-01 5 43454455 43454605 151 - 0.465 0.345 -0.663
ENSG00000151881 E012 6.669689 0.0028187448 5.587381e-02 1.194710e-01 5 43476114 43476234 121 - 0.892 0.606 -1.164
ENSG00000151881 E013 4.221057 0.0037424662 1.046089e-01 1.975265e-01 5 43476235 43476258 24 - 0.729 0.450 -1.259
ENSG00000151881 E014 3.558895 0.0052958243 5.473529e-01 6.774134e-01 5 43476259 43476275 17 - 0.635 0.535 -0.448
ENSG00000151881 E015 6.726706 0.0029354498 1.348317e-01 2.408647e-01 5 43479890 43479987 98 - 0.882 0.667 -0.863
ENSG00000151881 E016 11.830868 0.0396788346 5.750785e-03 1.795788e-02 5 43483822 43483893 72 - 1.137 0.667 -1.803