ENSG00000151849

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381884 ENSG00000151849 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPJ protein_coding protein_coding 7.469683 2.873771 9.093598 0.3907762 0.1757898 1.65848 1.3354810 0.85751706 1.783193 0.13408476 0.22261787 1.0475666 0.2199250 0.3085667 0.1953667 -0.1132000 0.27982733 0.01584559 FALSE TRUE
ENST00000418179 ENSG00000151849 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPJ protein_coding protein_coding 7.469683 2.873771 9.093598 0.3907762 0.1757898 1.65848 0.8503746 0.07958579 1.208837 0.07958579 0.24581056 3.7660918 0.1044833 0.0257000 0.1322000 0.1065000 0.10639982 0.01584559 FALSE TRUE
ENST00000493190 ENSG00000151849 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPJ protein_coding processed_transcript 7.469683 2.873771 9.093598 0.3907762 0.1757898 1.65848 2.0479033 0.94975628 1.758690 0.17224865 0.09446207 0.8819408 0.2779750 0.3304667 0.1933000 -0.1371667 0.01584559 0.01584559   FALSE
ENST00000545981 ENSG00000151849 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPJ protein_coding nonsense_mediated_decay 7.469683 2.873771 9.093598 0.3907762 0.1757898 1.65848 2.8749204 0.86471674 4.342878 0.28737212 0.28221720 2.3150819 0.3593542 0.2958667 0.4791333 0.1832667 0.22118927 0.01584559 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151849 E001 0.000000       13 24882279 24882283 5 -      
ENSG00000151849 E002 16.007249 0.0179091961 1.233708e-01 2.247632e-01 13 24882284 24883162 879 - 1.144 1.304 0.565
ENSG00000151849 E003 59.412507 0.0131217745 5.434051e-05 3.034173e-04 13 24883163 24883369 207 - 1.643 1.920 0.935
ENSG00000151849 E004 52.679981 0.0005646548 1.526469e-06 1.218544e-05 13 24883963 24884083 121 - 1.608 1.843 0.797
ENSG00000151849 E005 41.309662 0.0005435817 1.539420e-05 9.798361e-05 13 24884161 24884245 85 - 1.500 1.739 0.814
ENSG00000151849 E006 18.696836 0.0089307050 2.575218e-02 6.343106e-02 13 24884323 24884329 7 - 1.185 1.389 0.713
ENSG00000151849 E007 44.381888 0.0007172905 2.755352e-06 2.079820e-05 13 24884330 24884463 134 - 1.519 1.772 0.861
ENSG00000151849 E008 18.611054 0.0219194733 1.613741e-02 4.303590e-02 13 24885276 24885289 14 - 1.155 1.413 0.904
ENSG00000151849 E009 31.926354 0.0033808213 1.570437e-03 5.863165e-03 13 24885290 24885386 97 - 1.399 1.614 0.738
ENSG00000151849 E010 25.442129 0.0007844597 2.554046e-01 3.922916e-01 13 24885606 24885670 65 - 1.359 1.442 0.285
ENSG00000151849 E011 16.992050 0.0011511811 3.888504e-03 1.283195e-02 13 24885671 24886079 409 - 1.125 1.369 0.861
ENSG00000151849 E012 12.309730 0.0015769097 2.764744e-01 4.159400e-01 13 24886235 24886385 151 - 1.118 1.003 -0.421
ENSG00000151849 E013 4.594145 0.1761906190 1.874695e-01 3.105442e-01 13 24889170 24889315 146 - 0.791 0.498 -1.273
ENSG00000151849 E014 18.909582 0.0010961736 5.887707e-01 7.119296e-01 13 24889316 24889400 85 - 1.276 1.230 -0.162
ENSG00000151849 E015 48.413878 0.0005993033 8.708617e-01 9.209943e-01 13 24892643 24892867 225 - 1.656 1.665 0.031
ENSG00000151849 E016 47.015061 0.0005940618 3.347768e-01 4.785144e-01 13 24899419 24899584 166 - 1.660 1.607 -0.182
ENSG00000151849 E017 38.557871 0.0307278877 3.377385e-01 4.816369e-01 13 24903926 24904058 133 - 1.587 1.496 -0.310
ENSG00000151849 E018 177.360806 0.0018876146 4.921389e-08 5.313704e-07 13 24905346 24906960 1615 - 2.263 2.086 -0.593
ENSG00000151849 E019 25.043184 0.0007938276 2.266724e-03 8.050545e-03 13 24907091 24907193 103 - 1.448 1.202 -0.859
ENSG00000151849 E020 24.510397 0.0008012748 4.349527e-02 9.746230e-02 13 24908018 24908126 109 - 1.416 1.256 -0.555
ENSG00000151849 E021 38.723361 0.0009640598 1.437373e-05 9.206989e-05 13 24909790 24910086 297 - 1.633 1.338 -1.013
ENSG00000151849 E022 23.622089 0.0141855596 1.655414e-04 8.159997e-04 13 24911946 24912069 124 - 1.447 1.048 -1.410
ENSG00000151849 E023 43.668086 0.0019466638 3.520718e-10 5.664454e-09 13 24912582 24913091 510 - 1.710 1.270 -1.515
ENSG00000151849 E024 10.812276 0.0030188270 4.567180e-01 5.971033e-01 13 24922761 24922889 129 - 1.062 0.979 -0.306