ENSG00000151835

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382292 ENSG00000151835 HEK293_OSMI2_2hA HEK293_TMG_2hB SACS protein_coding protein_coding 4.760033 2.117159 7.413059 0.3379367 0.418049 1.803086 0.9277119 0.0000000 1.43042764 0.0000000 0.07694812 7.170353 0.13932917 0.0000000 0.193633333 0.1936333 4.220565e-11 1.507793e-23 FALSE TRUE
ENST00000402364 ENSG00000151835 HEK293_OSMI2_2hA HEK293_TMG_2hB SACS protein_coding protein_coding 4.760033 2.117159 7.413059 0.3379367 0.418049 1.803086 3.0479500 0.9177629 5.59566215 0.1763057 0.27436285 2.595057 0.61716667 0.4763667 0.755533333 0.2791667 1.624999e-01 1.507793e-23 FALSE TRUE
ENST00000683367 ENSG00000151835 HEK293_OSMI2_2hA HEK293_TMG_2hB SACS protein_coding protein_coding 4.760033 2.117159 7.413059 0.3379367 0.418049 1.803086 0.1698759 0.3291184 0.00000000 0.3291184 0.00000000 -5.083717 0.07301667 0.1178333 0.000000000 -0.1178333 5.327306e-01 1.507793e-23 FALSE TRUE
ENST00000683489 ENSG00000151835 HEK293_OSMI2_2hA HEK293_TMG_2hB SACS protein_coding protein_coding 4.760033 2.117159 7.413059 0.3379367 0.418049 1.803086 0.1701705 0.7525495 0.00880914 0.1197754 0.00880914 -5.341325 0.08140000 0.3573333 0.001133333 -0.3562000 1.507793e-23 1.507793e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151835 E001 0.0000000       13 23288689 23289243 555 -      
ENSG00000151835 E002 0.0000000       13 23310716 23310747 32 -      
ENSG00000151835 E003 0.0000000       13 23310748 23312115 1368 -      
ENSG00000151835 E004 0.0000000       13 23321566 23321674 109 -      
ENSG00000151835 E005 0.6600969 0.1169256185 2.405884e-01 3.748591e-01 13 23322301 23322644 344 - 0.162 0.288 1.053
ENSG00000151835 E006 0.0000000       13 23328826 23328829 4 -      
ENSG00000151835 E007 1.2532565 0.3160600577 3.407566e-02 7.990672e-02 13 23328830 23328832 3 - 0.162 0.567 2.578
ENSG00000151835 E008 8.2461694 0.0096627690 8.288974e-10 1.247475e-08 13 23328833 23328861 29 - 0.686 1.203 1.960
ENSG00000151835 E009 23.6434049 0.0172283636 8.830052e-14 2.531518e-12 13 23328862 23328928 67 - 1.143 1.620 1.656
ENSG00000151835 E010 38.8713850 0.0384913470 1.307129e-08 1.577272e-07 13 23328929 23328986 58 - 1.386 1.805 1.431
ENSG00000151835 E011 37.7965856 0.0370635701 1.485582e-08 1.773851e-07 13 23328987 23329022 36 - 1.382 1.788 1.387
ENSG00000151835 E012 33.5328016 0.0335630231 5.802746e-09 7.490037e-08 13 23329023 23329049 27 - 1.330 1.742 1.413
ENSG00000151835 E013 56.4311352 0.0131042505 1.918991e-22 1.607904e-20 13 23329050 23329201 152 - 1.514 1.983 1.587
ENSG00000151835 E014 21.8054640 0.0010302043 1.266050e-22 1.083820e-20 13 23329202 23329220 19 - 1.090 1.590 1.745
ENSG00000151835 E015 33.7041270 0.0006593223 6.371534e-33 1.322090e-30 13 23329221 23329249 29 - 1.281 1.771 1.680
ENSG00000151835 E016 30.7660811 0.0082588817 1.310060e-17 6.339387e-16 13 23329250 23329295 46 - 1.296 1.708 1.414
ENSG00000151835 E017 61.2322637 0.0050900537 1.172880e-22 1.007247e-20 13 23329296 23329484 189 - 1.643 1.951 1.040
ENSG00000151835 E018 80.2589944 0.0006084805 4.059735e-17 1.829894e-15 13 23329485 23329752 268 - 1.851 1.961 0.370
ENSG00000151835 E019 88.3367182 0.0024435760 2.275415e-06 1.748448e-05 13 23329753 23329952 200 - 1.944 1.917 -0.091
ENSG00000151835 E020 878.8479629 0.0624107687 3.351543e-03 1.129625e-02 13 23329953 23337421 7469 - 3.052 2.573 -1.592
ENSG00000151835 E021 280.4551569 0.0697253282 1.398501e-10 2.407906e-09 13 23337422 23341444 4023 - 2.613 1.539 -3.606
ENSG00000151835 E022 16.4421931 0.0117569619 5.572470e-04 2.374680e-03 13 23341445 23341532 88 - 1.377 0.716 -2.442
ENSG00000151835 E023 12.4645023 0.0013427110 3.996273e-03 1.313366e-02 13 23341533 23341584 52 - 1.255 0.676 -2.180
ENSG00000151835 E024 16.9840589 0.0047302906 1.322937e-03 5.053157e-03 13 23341585 23341690 106 - 1.382 0.789 -2.165
ENSG00000151835 E025 0.0000000       13 23346811 23346837 27 -      
ENSG00000151835 E026 0.0000000       13 23353736 23353776 41 -      
ENSG00000151835 E027 0.0000000       13 23353777 23353784 8 -      
ENSG00000151835 E028 15.3350987 0.0011410083 4.329670e-03 1.406838e-02 13 23353785 23353876 92 - 1.334 0.789 -2.000
ENSG00000151835 E029 1.5101918 0.0096790891 1.978528e-01 3.235360e-01 13 23353968 23354518 551 - 0.372 0.458 0.462
ENSG00000151835 E030 143.7193833 0.0003320401 5.470603e-01 6.771485e-01 13 23354519 23356007 1489 - 2.227 1.965 -0.878
ENSG00000151835 E031 23.7611219 0.0008993277 4.641344e-01 6.038969e-01 13 23358335 23358481 147 - 1.470 1.177 -1.022
ENSG00000151835 E032 0.1482932 0.0410891136 1.215431e-01   13 23362620 23363040 421 - 0.000 0.166 29.488
ENSG00000151835 E033 0.0000000       13 23363041 23363484 444 -      
ENSG00000151835 E034 1.0370979 0.2696985109 7.244046e-01 8.179343e-01 13 23363485 23365165 1681 - 0.329 0.281 -0.313
ENSG00000151835 E035 24.5247400 0.0072278257 1.407702e-01 2.490730e-01 13 23365166 23365277 112 - 1.499 1.133 -1.279
ENSG00000151835 E036 13.8592098 0.0316123196 3.023919e-02 7.243847e-02 13 23368402 23368417 16 - 1.291 0.753 -1.991
ENSG00000151835 E037 15.9679627 0.0085242373 2.018908e-02 5.187945e-02 13 23368418 23368487 70 - 1.343 0.850 -1.793
ENSG00000151835 E038 0.8867404 0.2006326999 2.436729e-01 3.784947e-01 13 23368488 23369511 1024 - 0.225 0.374 1.007
ENSG00000151835 E039 12.9071903 0.0013771084 8.038362e-02 1.601633e-01 13 23371078 23371165 88 - 1.243 0.821 -1.556
ENSG00000151835 E040 0.7512344 0.2785993746 3.768656e-01 5.211847e-01 13 23371166 23373693 2528 - 0.330 0.000 -29.997
ENSG00000151835 E041 9.9885854 0.0298454934 1.735463e-01 2.927860e-01 13 23375119 23375269 151 - 1.143 0.716 -1.620
ENSG00000151835 E042 4.2877422 0.0040142400 3.470454e-04 1.568423e-03 13 23375352 23375600 249 - 0.879 0.000 -32.526
ENSG00000151835 E043 0.0000000       13 23409390 23411219 1830 -      
ENSG00000151835 E044 1.1961139 0.3622307169 5.294546e-01 6.622272e-01 13 23411220 23411352 133 - 0.330 0.369 0.236
ENSG00000151835 E045 1.1875811 0.0158261170 3.206183e-01 4.637717e-01 13 23411353 23411740 388 - 0.329 0.380 0.308
ENSG00000151835 E046 0.2987644 0.0267983033 1.000000e+00   13 23433615 23433763 149 - 0.162 0.000 -28.669