ENSG00000151806

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281543 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding protein_coding 11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 4.5028338 1.2214755 8.1665184 0.3156702 0.8824742 2.7310987 0.40689167 0.26300000 0.42636667 0.16336667 0.17173967 0.01281345 FALSE TRUE
ENST00000506793 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding processed_transcript 11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 1.6902699 1.2190263 1.8682681 0.2711010 0.2270190 0.6118872 0.18120833 0.26710000 0.09793333 -0.16916667 0.01281345 0.01281345 FALSE TRUE
ENST00000511493 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding processed_transcript 11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 0.2550848 0.4360001 0.2827288 0.2187547 0.1414016 -0.6074792 0.03372500 0.09666667 0.01476667 -0.08190000 0.60533802 0.01281345   FALSE
ENST00000513775 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding nonsense_mediated_decay 11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 0.6272199 0.0000000 1.2668926 0.0000000 0.6728342 6.9964933 0.03395000 0.00000000 0.06820000 0.06820000 0.37726363 0.01281345   TRUE
MSTRG.24820.1 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding   11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 1.5436513 0.2968451 3.8362527 0.2968451 1.1919029 3.6478712 0.09073750 0.06143333 0.19866667 0.13723333 0.20707398 0.01281345 FALSE TRUE
MSTRG.24820.4 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding   11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 0.6611783 0.7295299 0.8936656 0.3837596 0.7048081 0.2891805 0.08180417 0.16246667 0.04760000 -0.11486667 0.72587565 0.01281345 FALSE TRUE
MSTRG.24820.7 ENSG00000151806 HEK293_OSMI2_2hA HEK293_TMG_2hB GUF1 protein_coding   11.10475 4.584432 19.09222 0.1725858 0.638745 2.055782 1.1880266 0.6815548 2.4019202 0.0169333 0.5763609 1.8022667 0.12872083 0.14933333 0.12756667 -0.02176667 0.80270339 0.01281345 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151806 E001 1.025558 0.0490876907 6.670032e-01 0.7743542365 4 44678420 44678426 7 + 0.296 0.217 -0.589
ENSG00000151806 E002 8.739227 0.0021622861 7.722510e-02 0.1550418907 4 44678427 44678454 28 + 0.969 0.745 -0.867
ENSG00000151806 E003 25.329579 0.0007825237 5.611172e-02 0.1198971065 4 44678455 44678493 39 + 1.376 1.237 -0.486
ENSG00000151806 E004 38.847399 0.0006502957 5.836492e-03 0.0181811671 4 44678494 44678585 92 + 1.560 1.388 -0.593
ENSG00000151806 E005 59.552744 0.0006415811 9.102926e-04 0.0036500909 4 44678586 44678787 202 + 1.742 1.573 -0.573
ENSG00000151806 E006 55.392937 0.0191522157 3.526567e-01 0.4969003689 4 44680441 44680552 112 + 1.691 1.634 -0.194
ENSG00000151806 E007 96.317899 0.0002914238 7.848627e-04 0.0032055278 4 44680694 44680842 149 + 1.940 1.816 -0.419
ENSG00000151806 E008 85.465095 0.0003748985 1.292359e-02 0.0357337804 4 44681123 44681203 81 + 1.880 1.789 -0.307
ENSG00000151806 E009 78.139724 0.0004038820 1.532307e-01 0.2660706448 4 44682334 44682411 78 + 1.832 1.789 -0.144
ENSG00000151806 E010 63.857918 0.0003960300 3.921206e-01 0.5360635624 4 44683235 44683318 84 + 1.743 1.725 -0.063
ENSG00000151806 E011 69.533168 0.0020050208 1.816746e-01 0.3033332261 4 44685959 44686023 65 + 1.786 1.740 -0.154
ENSG00000151806 E012 128.493188 0.0002554849 4.238100e-03 0.0138087383 4 44686510 44686713 204 + 2.056 1.973 -0.276
ENSG00000151806 E013 88.082041 0.0052530247 9.460072e-03 0.0274373793 4 44688007 44688146 140 + 1.902 1.776 -0.425
ENSG00000151806 E014 83.774157 0.0010075694 3.516714e-01 0.4959030272 4 44689286 44689409 124 + 1.859 1.841 -0.061
ENSG00000151806 E015 85.539466 0.0004030703 8.973627e-01 0.9384433945 4 44689843 44689975 133 + 1.855 1.887 0.108
ENSG00000151806 E016 91.429480 0.0003364643 7.628943e-01 0.8463923208 4 44690717 44690860 144 + 1.883 1.922 0.133
ENSG00000151806 E017 95.361721 0.0003715309 3.399518e-01 0.4838862948 4 44691666 44691799 134 + 1.895 1.961 0.223
ENSG00000151806 E018 1.206332 0.0143999309 5.409752e-01 0.6720225018 4 44694409 44694411 3 + 0.330 0.218 -0.807
ENSG00000151806 E019 96.117901 0.0003274348 8.053015e-01 0.8761634460 4 44694412 44694513 102 + 1.905 1.942 0.123
ENSG00000151806 E020 109.183882 0.0002703485 2.582313e-01 0.3954476897 4 44695615 44695734 120 + 1.951 2.022 0.236
ENSG00000151806 E021 75.335342 0.0003790482 6.262147e-02 0.1310594821 4 44697408 44697444 37 + 1.782 1.894 0.378
ENSG00000151806 E022 117.282167 0.0006526523 1.416754e-01 0.2503308830 4 44698544 44698684 141 + 1.980 2.063 0.279
ENSG00000151806 E023 139.432303 0.0047724980 1.281932e-01 0.2316398974 4 44698685 44699219 535 + 2.048 2.147 0.329
ENSG00000151806 E024 335.201089 0.0088262177 6.835783e-05 0.0003722173 4 44699220 44700840 1621 + 2.397 2.600 0.676
ENSG00000151806 E025 37.062618 0.0031530007 4.733388e-03 0.0151871649 4 44700841 44701227 387 + 1.548 1.352 -0.677
ENSG00000151806 E026 2.891874 0.1394354501 9.690409e-01 0.9846320254 4 44713215 44713519 305 + 0.536 0.556 0.093