ENSG00000151773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000444614 ENSG00000151773 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC122 protein_coding protein_coding 2.622525 1.059405 4.439933 0.06642617 0.2772435 2.056976 0.7813071 0.62808730 1.3310721 0.05091326 0.06343798 1.071561 0.31066250 0.59256667 0.30336667 -0.28920000 0.001812564 0.001812564 FALSE TRUE
ENST00000470137 ENSG00000151773 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC122 protein_coding processed_transcript 2.622525 1.059405 4.439933 0.06642617 0.2772435 2.056976 0.3662167 0.20400797 0.8604069 0.10200762 0.44178349 2.024025 0.10481667 0.18130000 0.19263333 0.01133333 1.000000000 0.001812564 FALSE TRUE
ENST00000476570 ENSG00000151773 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC122 protein_coding processed_transcript 2.622525 1.059405 4.439933 0.06642617 0.2772435 2.056976 0.1583215 0.05613886 0.1955427 0.01169095 0.02483103 1.635868 0.06972917 0.05493333 0.04410000 -0.01083333 0.978627559 0.001812564 FALSE TRUE
ENST00000611737 ENSG00000151773 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC122 protein_coding processed_transcript 2.622525 1.059405 4.439933 0.06642617 0.2772435 2.056976 0.2720239 0.00000000 0.3768853 0.00000000 0.37688534 5.273834 0.10590833 0.00000000 0.07546667 0.07546667 1.000000000 0.001812564   FALSE
ENST00000614023 ENSG00000151773 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC122 protein_coding protein_coding 2.622525 1.059405 4.439933 0.06642617 0.2772435 2.056976 0.2184860 0.05258673 0.2290940 0.02757994 0.09866293 1.933649 0.10045417 0.05240000 0.05210000 -0.00030000 0.991410970 0.001812564   FALSE
MSTRG.8674.3 ENSG00000151773 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC122 protein_coding   2.622525 1.059405 4.439933 0.06642617 0.2772435 2.056976 0.8261697 0.11858378 1.4469324 0.06113960 0.37330577 3.502153 0.30842500 0.11880000 0.33236667 0.21356667 0.308472475 0.001812564 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151773 E001 0.4502799 0.0361811627 0.46554161 0.60522263 13 43823909 43824011 103 - 0.189 0.000 -9.424
ENSG00000151773 E002 5.8521756 0.0081654123 0.03572151 0.08304598 13 43836352 43836583 232 - 0.683 0.963 1.099
ENSG00000151773 E003 28.1814604 0.0016922627 0.67254976 0.77849592 13 43836584 43837429 846 - 1.407 1.435 0.095
ENSG00000151773 E004 6.1461286 0.0033672247 0.16585467 0.28280668 13 43854088 43856622 2535 - 0.856 0.653 -0.824
ENSG00000151773 E005 2.0877621 0.0640452128 0.87229764 0.92186863 13 43858151 43858780 630 - 0.477 0.437 -0.202
ENSG00000151773 E006 15.9642428 0.0016340151 0.24612060 0.38138997 13 43858781 43858897 117 - 1.212 1.102 -0.392
ENSG00000151773 E007 39.9914639 0.0005926878 0.45377127 0.59448509 13 43859672 43860070 399 - 1.575 1.534 -0.139
ENSG00000151773 E008 7.2822469 0.0049167144 0.02148294 0.05461025 13 43868694 43868803 110 - 0.785 1.060 1.040
ENSG00000151773 E009 11.0552873 0.0018208596 0.13621227 0.24277725 13 43869331 43869489 159 - 0.988 1.140 0.553
ENSG00000151773 E010 0.2955422 0.0301881390 0.39685567   13 43874753 43874841 89 - 0.073 0.199 1.676
ENSG00000151773 E011 16.6308217 0.0015816622 0.16624551 0.28331756 13 43874842 43874927 86 - 1.231 1.102 -0.459
ENSG00000151773 E012 11.2835063 0.0023953045 0.69618668 0.79661326 13 43879631 43879765 135 - 1.056 1.014 -0.154