ENSG00000151748

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324679 ENSG00000151748 HEK293_OSMI2_2hA HEK293_TMG_2hB SAV1 protein_coding protein_coding 18.39183 8.658908 30.08792 0.8909924 0.8451611 1.795742 10.201225 6.955330 14.517592 0.6489605 0.7751459 1.0605320 0.63121250 0.8049333 0.48240000 -0.32253333 1.534270e-14 4.463222e-54 FALSE TRUE
ENST00000602664 ENSG00000151748 HEK293_OSMI2_2hA HEK293_TMG_2hB SAV1 protein_coding retained_intron 18.39183 8.658908 30.08792 0.8909924 0.8451611 1.795742 1.464787 1.067059 1.677149 0.1729952 0.2165702 0.6474901 0.09695417 0.1215667 0.05543333 -0.06613333 9.520557e-04 4.463222e-54   FALSE
MSTRG.9525.1 ENSG00000151748 HEK293_OSMI2_2hA HEK293_TMG_2hB SAV1 protein_coding   18.39183 8.658908 30.08792 0.8909924 0.8451611 1.795742 4.914962 0.000000 10.778258 0.0000000 0.3594171 10.0752462 0.18132083 0.0000000 0.35830000 0.35830000 4.463222e-54 4.463222e-54 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151748 E001 0.6266857 0.0169188400 3.885310e-01 5.326091e-01 14 50616923 50616991 69 - 0.151 0.305 1.297
ENSG00000151748 E002 39.9630195 0.0005127703 4.936812e-02 1.080333e-01 14 50632058 50633579 1522 - 1.620 1.507 -0.385
ENSG00000151748 E003 130.8493813 0.0097626043 1.419969e-12 3.391867e-11 14 50633580 50634047 468 - 1.920 2.320 1.342
ENSG00000151748 E004 128.1676777 0.0003219477 5.762021e-08 6.126375e-07 14 50634048 50634174 127 - 2.021 2.200 0.600
ENSG00000151748 E005 256.8366821 0.0012162848 2.656760e-05 1.600366e-04 14 50634175 50634827 653 - 2.345 2.460 0.384
ENSG00000151748 E006 81.6660811 0.0003769603 3.749025e-04 1.676997e-03 14 50634828 50635088 261 - 1.839 1.989 0.503
ENSG00000151748 E007 32.4958680 0.0008798031 7.609153e-05 4.095026e-04 14 50635089 50635112 24 - 1.399 1.652 0.867
ENSG00000151748 E008 75.5930360 0.0003234398 1.850199e-01 3.075175e-01 14 50635113 50635213 101 - 1.838 1.901 0.212
ENSG00000151748 E009 159.1113671 0.0002165414 2.391571e-02 5.963329e-02 14 50635214 50635384 171 - 2.198 2.137 -0.201
ENSG00000151748 E010 167.8106350 0.0010164375 5.440730e-04 2.324762e-03 14 50640750 50640893 144 - 2.233 2.128 -0.352
ENSG00000151748 E011 209.1218167 0.0004362414 2.672817e-05 1.609271e-04 14 50644744 50645014 271 - 2.329 2.222 -0.358
ENSG00000151748 E012 29.3703718 0.0034520467 3.952246e-04 1.756124e-03 14 50664256 50665178 923 - 1.358 1.610 0.868
ENSG00000151748 E013 267.3408086 0.0009843616 2.482853e-10 4.089098e-09 14 50665179 50665600 422 - 2.450 2.286 -0.545
ENSG00000151748 E014 73.9464862 0.0006548483 1.105651e-03 4.322017e-03 14 50665601 50665619 19 - 1.893 1.749 -0.486
ENSG00000151748 E015 4.0233288 0.0041640101 4.840625e-01 6.220818e-01 14 50667147 50667381 235 - 0.712 0.609 -0.439
ENSG00000151748 E016 5.4428782 0.0511652899 6.040162e-01 7.246707e-01 14 50667382 50667500 119 - 0.820 0.743 -0.308
ENSG00000151748 E017 165.5840429 0.0097221602 4.974471e-05 2.805008e-04 14 50667874 50668318 445 - 2.257 2.031 -0.756