ENSG00000151746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000547680 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding protein_coding 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.3387652 0.44557989 0.2889335 0.06324182 0.0596917743 -0.60787930 0.10044583 0.16616667 0.09590000 -0.07026667 0.33511605 0.01298341   FALSE
ENST00000548411 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding protein_coding 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.5129962 0.10298912 0.3832353 0.10298912 0.2227098432 1.79920897 0.12712500 0.04943333 0.10690000 0.05746667 0.66296390 0.01298341 FALSE TRUE
ENST00000550207 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding protein_coding 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.5087206 0.24270668 0.4441723 0.03627650 0.0227135662 0.84577594 0.13533750 0.09276667 0.14010000 0.04733333 0.49377539 0.01298341   FALSE
ENST00000551848 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding protein_coding 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.3437249 0.36697078 0.3448860 0.06637429 0.0045628494 -0.08709719 0.10730833 0.14623333 0.10936667 -0.03686667 0.80626047 0.01298341   FALSE
ENST00000552160 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding protein_coding 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.3449234 0.30018890 0.1635567 0.04983696 0.0880548179 -0.83773962 0.09195000 0.11103333 0.04650000 -0.06453333 0.28860895 0.01298341 FALSE TRUE
ENST00000552226 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding retained_intron 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.1897217 0.22472830 0.3090774 0.08283644 0.1188204003 0.44291451 0.05365417 0.07883333 0.09726667 0.01843333 0.89994714 0.01298341   FALSE
ENST00000614004 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding retained_intron 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.3257769 0.30141460 0.1123086 0.03811279 0.0005423756 -1.34831018 0.09703750 0.11030000 0.03570000 -0.07460000 0.01298341 0.01298341   FALSE
ENST00000652176 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding protein_coding 3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.1407329 0.09271259 0.3978048 0.09271259 0.0889238786 1.98926583 0.03920833 0.03333333 0.12346667 0.09013333 0.22049866 0.01298341 FALSE TRUE
MSTRG.7090.8 ENSG00000151746 HEK293_OSMI2_2hA HEK293_TMG_2hB BICD1 protein_coding   3.640495 2.737418 3.221585 0.3657398 0.3290424 0.2341656 0.6510647 0.52486885 0.5190139 0.26488108 0.2750099486 -0.01587969 0.15690000 0.17150000 0.14566667 -0.02583333 0.98873965 0.01298341 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151746 E001 3.2000102 0.062666275 2.715518e-01 4.103273e-01 12 32106835 32106846 12 + 0.539 0.723 0.801
ENSG00000151746 E002 3.8182623 0.047907980 7.850163e-02 1.570870e-01 12 32106847 32106884 38 + 0.539 0.820 1.191
ENSG00000151746 E003 9.4563966 0.018278046 6.584920e-01 7.676032e-01 12 32106885 32107150 266 + 0.993 1.038 0.165
ENSG00000151746 E004 7.9462949 0.012392713 5.871475e-01 7.104883e-01 12 32107151 32107251 101 + 0.971 0.898 -0.276
ENSG00000151746 E005 5.7582742 0.016006132 5.059417e-01 6.416464e-01 12 32107252 32107295 44 + 0.854 0.759 -0.373
ENSG00000151746 E006 9.1098979 0.003611715 3.047962e-01 4.468208e-01 12 32107296 32107356 61 + 0.948 1.055 0.394
ENSG00000151746 E007 19.0945729 0.001096901 3.895922e-01 5.336660e-01 12 32107357 32107544 188 + 1.266 1.327 0.214
ENSG00000151746 E008 2.2572735 0.050710717 4.762909e-01 6.149345e-01 12 32107545 32107661 117 + 0.569 0.433 -0.663
ENSG00000151746 E009 3.0376527 0.040852189 1.609976e-01 2.764229e-01 12 32107662 32107673 12 + 0.694 0.434 -1.198
ENSG00000151746 E010 20.2460186 0.011472707 1.703310e-03 6.293628e-03 12 32107674 32108644 971 + 1.198 1.465 0.933
ENSG00000151746 E011 1.8401868 0.008338475 2.077814e-03 7.465399e-03 12 32108645 32108806 162 + 0.174 0.688 2.977
ENSG00000151746 E012 16.3738152 0.001132550 6.585076e-01 7.676167e-01 12 32216247 32216459 213 + 1.249 1.206 -0.150
ENSG00000151746 E013 0.8856816 0.118630418 3.185789e-01 4.615477e-01 12 32222804 32222855 52 + 0.174 0.362 1.407
ENSG00000151746 E014 9.9134750 0.001796357 4.721824e-01 6.112389e-01 12 32293994 32294146 153 + 1.064 0.983 -0.296
ENSG00000151746 E015 18.6532885 0.004113935 1.210694e-01 2.214670e-01 12 32305697 32306122 426 + 1.340 1.206 -0.473
ENSG00000151746 E016 38.6776132 0.000633620 9.099043e-01 9.467241e-01 12 32327461 32328401 941 + 1.590 1.590 0.001
ENSG00000151746 E017 9.3899348 0.001929688 2.266073e-02 5.704842e-02 12 32328402 32328555 154 + 0.897 1.130 0.859
ENSG00000151746 E018 6.2968621 0.002795137 4.096402e-04 1.811214e-03 12 32332454 32333065 612 + 0.623 1.055 1.693
ENSG00000151746 E019 2.9580271 0.005378063 4.679894e-01 6.074170e-01 12 32334516 32334516 1 + 0.539 0.648 0.487
ENSG00000151746 E020 7.5205302 0.052805352 5.801886e-01 7.049781e-01 12 32334517 32334667 151 + 0.898 0.961 0.240
ENSG00000151746 E021 10.4429156 0.023880189 1.541567e-01 2.673184e-01 12 32337499 32337706 208 + 0.972 1.133 0.589
ENSG00000151746 E022 4.9985531 0.004102444 1.438757e-03 5.435708e-03 12 32337707 32337816 110 + 0.539 0.963 1.736
ENSG00000151746 E023 6.8457776 0.048000445 2.969755e-03 1.017294e-02 12 32337817 32338785 969 + 0.648 1.088 1.706
ENSG00000151746 E024 5.6465534 0.003110213 2.972866e-01 4.386092e-01 12 32338786 32338979 194 + 0.869 0.725 -0.570
ENSG00000151746 E025 1.4715823 0.010021446 6.067540e-01 7.268411e-01 12 32338980 32339120 141 + 0.348 0.435 0.487
ENSG00000151746 E026 1.3618961 0.010189312 2.659362e-02 6.514657e-02 12 32367534 32367669 136 + 0.174 0.554 2.393
ENSG00000151746 E027 3.5482723 0.004508592 5.024898e-02 1.095999e-01 12 32367670 32367745 76 + 0.754 0.435 -1.439
ENSG00000151746 E028 1.7326917 0.008133366 4.045217e-04 1.791982e-03 12 32367746 32368062 317 + 0.095 0.688 3.977
ENSG00000151746 E029 76.4308048 0.004700700 7.100889e-12 1.515052e-10 12 32377540 32383633 6094 + 1.984 1.654 -1.114