ENSG00000151743

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281471 ENSG00000151743 HEK293_OSMI2_2hA HEK293_TMG_2hB AMN1 protein_coding protein_coding 4.52463 3.122062 6.402399 0.1402867 0.537575 1.033751 1.8062354 1.1255183 2.2348686 0.3837440 0.1659571 0.9832800 0.38686250 0.3729667 0.34973333 -0.02323333 1.000000e+00 4.478075e-06 FALSE TRUE
ENST00000422146 ENSG00000151743 HEK293_OSMI2_2hA HEK293_TMG_2hB AMN1 protein_coding processed_transcript 4.52463 3.122062 6.402399 0.1402867 0.537575 1.033751 0.5150113 0.9686020 0.3834691 0.3169470 0.2593972 -1.3144717 0.16603333 0.3021333 0.05520000 -0.24693333 1.512613e-01 4.478075e-06 FALSE FALSE
ENST00000536761 ENSG00000151743 HEK293_OSMI2_2hA HEK293_TMG_2hB AMN1 protein_coding protein_coding 4.52463 3.122062 6.402399 0.1402867 0.537575 1.033751 0.3491214 0.0000000 0.5857148 0.0000000 0.1261395 5.8965498 0.05821250 0.0000000 0.09016667 0.09016667 4.478075e-06 4.478075e-06 FALSE TRUE
ENST00000541541 ENSG00000151743 HEK293_OSMI2_2hA HEK293_TMG_2hB AMN1 protein_coding processed_transcript 4.52463 3.122062 6.402399 0.1402867 0.537575 1.033751 0.3407559 0.4426751 0.5019976 0.1726093 0.1680763 0.1776611 0.08768333 0.1444667 0.07823333 -0.06623333 6.802446e-01 4.478075e-06 FALSE FALSE
ENST00000541931 ENSG00000151743 HEK293_OSMI2_2hA HEK293_TMG_2hB AMN1 protein_coding protein_coding 4.52463 3.122062 6.402399 0.1402867 0.537575 1.033751 0.9891672 0.1202022 2.1781269 0.1202022 0.1232941 4.0708712 0.19026250 0.0372000 0.34893333 0.31173333 2.581316e-02 4.478075e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151743 E001 35.4853943 0.0260532475 7.458026e-01 8.337369e-01 12 31671142 31671944 803 - 1.525 1.603 0.267
ENSG00000151743 E002 15.5823123 0.0045963167 4.673582e-01 6.068638e-01 12 31671945 31672169 225 - 1.174 1.263 0.317
ENSG00000151743 E003 12.0283361 0.0015948334 5.454199e-02 1.171893e-01 12 31672170 31672277 108 - 1.012 1.218 0.744
ENSG00000151743 E004 24.9813484 0.0008849809 1.743072e-01 2.937847e-01 12 31672278 31672377 100 - 1.435 1.368 -0.229
ENSG00000151743 E005 0.6192988 0.0222911205 6.815230e-01 7.851886e-01 12 31673552 31673638 87 - 0.229 0.164 -0.605
ENSG00000151743 E006 31.7211693 0.0007115979 2.742662e-03 9.500188e-03 12 31689007 31689118 112 - 1.562 1.401 -0.552
ENSG00000151743 E007 24.5600545 0.0009028459 1.616859e-02 4.309646e-02 12 31697361 31697417 57 - 1.449 1.305 -0.501
ENSG00000151743 E008 37.7194284 0.0006133797 3.171165e-04 1.449170e-03 12 31697740 31697957 218 - 1.640 1.460 -0.616
ENSG00000151743 E009 10.8092904 0.0020966665 1.523757e-01 2.649161e-01 12 31701863 31701867 5 - 1.108 0.986 -0.447
ENSG00000151743 E010 21.1361468 0.0011724821 1.500458e-01 2.617374e-01 12 31701868 31701991 124 - 1.367 1.285 -0.286
ENSG00000151743 E011 9.5893397 0.0019302861 6.984800e-01 7.984448e-01 12 31701992 31701998 7 - 1.021 1.006 -0.058
ENSG00000151743 E012 9.5850733 0.0026056228 6.989622e-01 7.988098e-01 12 31701999 31702007 9 - 1.021 1.006 -0.058
ENSG00000151743 E013 7.5412018 0.0893181439 1.556076e-02 4.175670e-02 12 31708570 31708917 348 - 0.715 1.134 1.589
ENSG00000151743 E014 4.6664302 0.0412910574 6.969360e-04 2.887849e-03 12 31708918 31708957 40 - 0.456 1.004 2.294
ENSG00000151743 E015 5.2879176 0.1224451863 5.103139e-03 1.621236e-02 12 31708958 31709010 53 - 0.490 1.045 2.274
ENSG00000151743 E016 4.3041790 0.2029013663 1.923141e-02 4.983680e-02 12 31709011 31709052 42 - 0.420 0.968 2.348
ENSG00000151743 E017 3.8288808 0.0044084186 8.041500e-06 5.457417e-05 12 31709053 31709079 27 - 0.285 0.965 3.148
ENSG00000151743 E018 4.0063188 0.0043833251 3.382382e-06 2.503642e-05 12 31709080 31709091 12 - 0.285 0.986 3.226
ENSG00000151743 E019 6.3345372 0.0108014469 2.881135e-06 2.164072e-05 12 31709092 31709167 76 - 0.490 1.126 2.567
ENSG00000151743 E020 21.9447381 0.0120385254 1.202687e-01 2.203704e-01 12 31709293 31709425 133 - 1.281 1.433 0.531
ENSG00000151743 E021 1.4997836 0.2092459533 9.670020e-01 9.833216e-01 12 31714441 31714631 191 - 0.378 0.382 0.024
ENSG00000151743 E022 1.6825347 0.0955806172 2.911299e-01 4.319579e-01 12 31714882 31714951 70 - 0.489 0.282 -1.186
ENSG00000151743 E023 3.3381147 0.0957555938 1.912774e-01 3.153358e-01 12 31719218 31719356 139 - 0.713 0.451 -1.191
ENSG00000151743 E024 12.2980546 0.0014130876 5.014950e-02 1.094277e-01 12 31728971 31728990 20 - 1.174 1.006 -0.608
ENSG00000151743 E025 12.3839808 0.0013981455 1.392932e-02 3.806408e-02 12 31728991 31729121 131 - 1.187 0.965 -0.806