ENSG00000151726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281455 ENSG00000151726 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL1 protein_coding protein_coding 11.15346 8.191703 15.484 0.9250561 0.3052351 0.9177142 7.987947 4.00317398 11.5452408 0.6274091 0.7325335 1.525732 0.69822917 0.484266667 0.74480000 0.26053333 0.0005950723 0.0002154154 FALSE TRUE
ENST00000454703 ENSG00000151726 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL1 protein_coding protein_coding 11.15346 8.191703 15.484 0.9250561 0.3052351 0.9177142 1.188425 0.92068818 2.3467805 0.4609585 0.6441681 1.340448 0.09621250 0.125933333 0.15150000 0.02556667 0.8539474592 0.0002154154 FALSE TRUE
ENST00000503407 ENSG00000151726 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL1 protein_coding protein_coding 11.15346 8.191703 15.484 0.9250561 0.3052351 0.9177142 1.179436 3.05467580 0.1883516 0.7442400 0.1883516 -3.949602 0.14226250 0.362500000 0.01266667 -0.34983333 0.0034239718 0.0002154154 FALSE TRUE
MSTRG.25810.7 ENSG00000151726 HEK293_OSMI2_2hA HEK293_TMG_2hB ACSL1 protein_coding   11.15346 8.191703 15.484 0.9250561 0.3052351 0.9177142 0.339364 0.03982364 0.9154939 0.0204988 0.1952630 4.215321 0.02297083 0.004566667 0.05950000 0.05493333 0.0002154154 0.0002154154 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151726 E001 1.5759569 0.0495841834 8.515161e-01 9.079295e-01 4 184755595 184755599 5 - 0.413 0.380 -0.185
ENSG00000151726 E002 1.9059545 0.0262899713 5.607714e-01 6.887072e-01 4 184755600 184755600 1 - 0.413 0.522 0.549
ENSG00000151726 E003 394.9498107 0.0006615863 2.776678e-33 5.991267e-31 4 184755601 184756780 1180 - 2.483 2.722 0.795
ENSG00000151726 E004 63.5033541 0.0052404635 2.139575e-02 5.442433e-02 4 184756781 184756858 78 - 1.742 1.873 0.442
ENSG00000151726 E005 69.7498553 0.0065907928 6.194086e-02 1.298856e-01 4 184756859 184756902 44 - 1.792 1.902 0.370
ENSG00000151726 E006 96.5689499 0.0016840392 8.763114e-01 9.246198e-01 4 184756903 184757020 118 - 1.972 1.987 0.051
ENSG00000151726 E007 58.9602675 0.0032043506 8.286883e-01 8.923715e-01 4 184757021 184757046 26 - 1.769 1.767 -0.007
ENSG00000151726 E008 124.1593602 0.0002656247 1.701705e-01 2.884068e-01 4 184757047 184757265 219 - 2.067 2.121 0.181
ENSG00000151726 E009 68.2071699 0.0008693295 8.649445e-01 9.169675e-01 4 184757635 184757706 72 - 1.830 1.832 0.008
ENSG00000151726 E010 84.0152450 0.0049145744 7.964375e-01 8.700722e-01 4 184757819 184757920 102 - 1.921 1.920 -0.003
ENSG00000151726 E011 2.3982790 0.1055745399 9.151527e-01 9.502855e-01 4 184757921 184758876 956 - 0.515 0.523 0.040
ENSG00000151726 E012 94.7602889 0.0116628653 9.581194e-01 9.777469e-01 4 184760357 184760500 144 - 1.963 1.986 0.076
ENSG00000151726 E013 63.3576198 0.0029053932 9.082695e-01 9.457194e-01 4 184762407 184762493 87 - 1.798 1.803 0.017
ENSG00000151726 E014 42.4009180 0.0005192879 2.155351e-01 3.450568e-01 4 184762494 184762523 30 - 1.648 1.588 -0.204
ENSG00000151726 E015 57.1634534 0.0027035015 2.803034e-01 4.201624e-01 4 184763167 184763255 89 - 1.771 1.721 -0.168
ENSG00000151726 E016 46.4086257 0.0150978843 4.530996e-02 1.007575e-01 4 184764853 184764925 73 - 1.716 1.558 -0.534
ENSG00000151726 E017 44.8735357 0.0004844883 1.346763e-01 2.406465e-01 4 184765891 184765986 96 - 1.676 1.603 -0.246
ENSG00000151726 E018 69.3291551 0.0004135473 2.189400e-01 3.491260e-01 4 184766622 184766756 135 - 1.850 1.805 -0.151
ENSG00000151726 E019 0.5181333 0.0210970464 1.000000e+00 1.000000e+00 4 184768030 184768315 286 - 0.163 0.166 0.036
ENSG00000151726 E020 40.4482846 0.0121059599 7.954997e-01 8.694090e-01 4 184768316 184768327 12 - 1.609 1.589 -0.067
ENSG00000151726 E021 85.8739592 0.0090050438 2.739514e-01 4.130562e-01 4 184768328 184768450 123 - 1.946 1.887 -0.201
ENSG00000151726 E022 3.1513622 0.0200767180 4.501084e-01 5.912776e-01 4 184770255 184770332 78 - 0.645 0.523 -0.550
ENSG00000151726 E023 72.2318299 0.0005406226 5.160385e-02 1.120057e-01 4 184770399 184770476 78 - 1.878 1.802 -0.258
ENSG00000151726 E024 66.5693005 0.0003574480 8.029913e-03 2.385627e-02 4 184773081 184773154 74 - 1.856 1.744 -0.376
ENSG00000151726 E025 53.9190495 0.0004631793 5.773699e-02 1.227524e-01 4 184773663 184773714 52 - 1.759 1.673 -0.291
ENSG00000151726 E026 48.8630506 0.0006036426 2.602598e-02 6.399812e-02 4 184773843 184773875 33 - 1.723 1.613 -0.373
ENSG00000151726 E027 90.7775933 0.0003237863 5.674422e-03 1.775161e-02 4 184776484 184776662 179 - 1.985 1.886 -0.332
ENSG00000151726 E028 68.5672851 0.0004155000 6.936058e-03 2.105726e-02 4 184776884 184776983 100 - 1.868 1.755 -0.381
ENSG00000151726 E029 61.1069124 0.0012353449 3.076680e-05 1.825798e-04 4 184780332 184780433 102 - 1.846 1.642 -0.691
ENSG00000151726 E030 51.3964207 0.0024809178 7.804953e-04 3.189441e-03 4 184783927 184783991 65 - 1.767 1.582 -0.628
ENSG00000151726 E031 0.3289534 0.0298952975 6.082569e-01   4 184788379 184788513 135 - 0.089 0.166 1.035
ENSG00000151726 E032 69.2998774 0.0005856269 8.943738e-05 4.723362e-04 4 184788617 184788731 115 - 1.890 1.718 -0.581
ENSG00000151726 E033 65.7524335 0.0004647785 4.686308e-04 2.040185e-03 4 184803320 184803546 227 - 1.864 1.710 -0.520
ENSG00000151726 E034 0.0000000       4 184805527 184805788 262 -      
ENSG00000151726 E035 0.2214452 0.0526051075 2.410763e-01   4 184808292 184808451 160 - 0.000 0.167 10.304
ENSG00000151726 E036 0.0000000       4 184812160 184812259 100 -      
ENSG00000151726 E037 26.8519669 0.0025511586 7.998533e-02 1.595386e-01 4 184825916 184826119 204 - 1.472 1.351 -0.420
ENSG00000151726 E038 0.0000000       4 184826525 184826818 294 -