ENSG00000151718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403733 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding protein_coding 3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 2.36582363 0.13300132 4.7018175 0.13300132 0.3120661 5.0421832 0.57080833 0.10606667 0.71386667 0.6078000 0.01732266 0.01253013 FALSE TRUE
ENST00000427431 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding nonsense_mediated_decay 3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 0.03334108 0.07251790 0.0000000 0.07251790 0.0000000 -3.0447071 0.02420833 0.05080000 0.00000000 -0.0508000 0.39380928 0.01253013 FALSE TRUE
ENST00000448232 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding protein_coding 3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 0.32842471 0.39003804 0.3128236 0.10819570 0.1651359 -0.3093909 0.09575000 0.30693333 0.04746667 -0.2594667 0.07686514 0.01253013 FALSE TRUE
ENST00000504005 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding protein_coding 3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 0.07083362 0.35528359 0.0000000 0.17986492 0.0000000 -5.1909450 0.04983750 0.30030000 0.00000000 -0.3003000 0.03785582 0.01253013 FALSE TRUE
ENST00000513834 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding protein_coding 3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 0.01627081 0.10597380 0.0000000 0.10597380 0.0000000 -3.5357271 0.01392500 0.10800000 0.00000000 -0.1080000 0.47532546 0.01253013 FALSE TRUE
ENST00000515284 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding retained_intron 3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 0.56060294 0.02994289 0.9795629 0.02994289 0.1250899 4.6307808 0.12191667 0.02096667 0.14830000 0.1273333 0.01253013 0.01253013   FALSE
MSTRG.25781.4 ENSG00000151718 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC2 protein_coding   3.91457 1.220865 6.593406 0.1297761 0.0801542 2.423537 0.36446981 0.13410791 0.4782799 0.13410791 0.2292092 1.7605588 0.08638333 0.10693333 0.07193333 -0.0350000 0.85731315 0.01253013 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151718 E001 8.6446227 0.0018963279 1.497882e-03 5.629226e-03 4 183099257 183099338 82 + 0.936 0.408 -2.293
ENSG00000151718 E002 14.2647280 0.0038541053 3.278432e-05 1.932269e-04 4 183099339 183099491 153 + 1.135 0.523 -2.439
ENSG00000151718 E003 19.1248782 0.0050602223 6.673065e-04 2.778689e-03 4 183099492 183099622 131 + 1.239 0.859 -1.392
ENSG00000151718 E004 12.8930569 0.0087034251 1.338235e-01 2.394683e-01 4 183193599 183193614 16 + 1.055 0.904 -0.561
ENSG00000151718 E005 20.3413621 0.0097703144 1.693347e-02 4.478626e-02 4 183193615 183193708 94 + 1.249 1.015 -0.840
ENSG00000151718 E006 0.1515154 0.0428826618 1.000000e+00   4 183203516 183203603 88 + 0.055 0.000 -8.089
ENSG00000151718 E007 39.9563367 0.0005179236 7.482362e-04 3.072329e-03 4 183207953 183208156 204 + 1.526 1.311 -0.742
ENSG00000151718 E008 18.3257544 0.0009889265 4.566213e-01 5.970098e-01 4 183208949 183208978 30 + 1.177 1.153 -0.084
ENSG00000151718 E009 21.3229783 0.0009037786 4.290423e-02 9.636246e-02 4 183208979 183209025 47 + 1.259 1.103 -0.556
ENSG00000151718 E010 26.6680151 0.0017957388 8.347127e-02 1.649863e-01 4 183240183 183240262 80 + 1.344 1.239 -0.370
ENSG00000151718 E011 30.7026831 0.0008596623 2.067764e-02 5.290741e-02 4 183245416 183245545 130 + 1.407 1.258 -0.518
ENSG00000151718 E012 32.5155045 0.0021678356 4.710212e-03 1.512461e-02 4 183248714 183248860 147 + 1.438 1.239 -0.692
ENSG00000151718 E013 26.3245232 0.0050262305 1.423593e-02 3.876200e-02 4 183249920 183249993 74 + 1.350 1.153 -0.690
ENSG00000151718 E014 44.4874131 0.0004986671 4.074854e-02 9.241262e-02 4 183253757 183253999 243 + 1.553 1.463 -0.310
ENSG00000151718 E015 27.6297880 0.0379237314 9.698257e-01 9.851152e-01 4 183259639 183259728 90 + 1.325 1.395 0.243
ENSG00000151718 E016 80.9444794 0.0003364892 1.214166e-01 2.219522e-01 4 183260910 183261385 476 + 1.796 1.774 -0.076
ENSG00000151718 E017 39.2877970 0.0005789462 1.421018e-01 2.508971e-01 4 183261386 183261532 147 + 1.493 1.439 -0.185
ENSG00000151718 E018 38.2079230 0.0006743590 5.868519e-01 7.103070e-01 4 183264978 183265107 130 + 1.469 1.485 0.056
ENSG00000151718 E019 34.9249602 0.0006590896 8.090006e-01 8.786792e-01 4 183265688 183265768 81 + 1.423 1.496 0.254
ENSG00000151718 E020 21.7977370 0.0008863724 9.071258e-01 9.450220e-01 4 183265865 183265868 4 + 1.229 1.294 0.230
ENSG00000151718 E021 34.6245868 0.0006112092 9.557791e-01 9.762527e-01 4 183265869 183265951 83 + 1.423 1.474 0.178
ENSG00000151718 E022 43.2969959 0.0006059006 9.980465e-01 1.000000e+00 4 183268971 183269118 148 + 1.518 1.575 0.192
ENSG00000151718 E023 26.6323055 0.0061085002 8.244545e-01 8.894103e-01 4 183269119 183269163 45 + 1.311 1.387 0.262
ENSG00000151718 E024 0.0000000       4 183269419 183269603 185 +      
ENSG00000151718 E025 0.7342825 0.0161356832 3.990345e-01 5.427815e-01 4 183269762 183269850 89 + 0.225 0.000 -10.410
ENSG00000151718 E026 0.2966881 0.0270963252 1.000000e+00   4 183269851 183270038 188 + 0.105 0.000 -9.089
ENSG00000151718 E027 35.5533981 0.0006236267 1.423794e-02 3.876596e-02 4 183271080 183271211 132 + 1.471 1.327 -0.500
ENSG00000151718 E028 26.4929284 0.0008217359 4.853672e-02 1.065757e-01 4 183271212 183271241 30 + 1.347 1.219 -0.449
ENSG00000151718 E029 51.0569580 0.0035346841 1.410430e-02 3.846234e-02 4 183280776 183280897 122 + 1.620 1.496 -0.424
ENSG00000151718 E030 6.1605236 0.0026865375 5.826705e-01 7.069793e-01 4 183280898 183280969 72 + 0.729 0.859 0.514
ENSG00000151718 E031 4.8229412 0.0037115512 1.511402e-02 4.074488e-02 4 183280970 183281386 417 + 0.718 0.250 -2.440
ENSG00000151718 E032 1.9231113 0.0099305345 5.869021e-02 1.243880e-01 4 183282607 183282707 101 + 0.442 0.000 -11.789
ENSG00000151718 E033 62.4081263 0.0003673256 2.774449e-01 4.170108e-01 4 183282708 183282906 199 + 1.685 1.678 -0.021
ENSG00000151718 E034 54.5078565 0.0004654379 4.297008e-01 5.723956e-01 4 183284226 183284390 165 + 1.603 1.706 0.350
ENSG00000151718 E035 41.6885219 0.0007759228 3.192310e-01 4.622908e-01 4 183285967 183286059 93 + 1.487 1.609 0.419
ENSG00000151718 E036 63.0284564 0.0004384144 2.240861e-01 3.552980e-01 4 183289393 183289635 243 + 1.662 1.785 0.415
ENSG00000151718 E037 45.8071094 0.0005814962 5.854826e-01 7.091738e-01 4 183312341 183312454 114 + 1.534 1.626 0.312
ENSG00000151718 E038 21.4776462 0.0008696648 5.509106e-01 6.804561e-01 4 183312455 183312468 14 + 1.218 1.327 0.382
ENSG00000151718 E039 270.6904988 0.0114265876 1.332517e-09 1.929980e-08 4 183315663 183320777 5115 + 2.234 2.571 1.124