ENSG00000151694

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310823 ENSG00000151694 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM17 protein_coding protein_coding 10.32978 3.316338 15.75103 0.1872415 0.6286878 2.244355 8.1769131 3.108257 11.7729036 0.2571082 0.5561197 1.917883 0.83792500 0.9359 0.74713333 -0.18876667 0.041350323 0.000477843 FALSE TRUE
ENST00000647979 ENSG00000151694 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM17 protein_coding nonsense_mediated_decay 10.32978 3.316338 15.75103 0.1872415 0.6286878 2.244355 0.5050912 0.000000 0.8063356 0.0000000 0.1532819 6.351091 0.03112917 0.0000 0.05176667 0.05176667 0.000477843 0.000477843 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151694 E001 18.6333307 0.0009502943 2.210344e-10 3.671896e-09 2 9488486 9488636 151 - 1.030 1.574 1.907
ENSG00000151694 E002 176.3558463 0.0102887457 3.797534e-13 9.950641e-12 2 9488637 9489287 651 - 2.038 2.455 1.392
ENSG00000151694 E003 37.6030755 0.0005974984 1.051479e-04 5.458269e-04 2 9489288 9489394 107 - 1.434 1.707 0.932
ENSG00000151694 E004 60.9761166 0.0008819115 1.908632e-04 9.248637e-04 2 9489395 9489588 194 - 1.654 1.876 0.753
ENSG00000151694 E005 76.8922105 0.0003889376 1.153578e-03 4.483278e-03 2 9489589 9489810 222 - 1.765 1.945 0.606
ENSG00000151694 E006 41.9868736 0.0005414638 9.327981e-03 2.710324e-02 2 9489811 9489856 46 - 1.506 1.696 0.647
ENSG00000151694 E007 158.8935755 0.0016386800 4.032484e-01 5.470327e-01 2 9489857 9490358 502 - 2.109 2.172 0.211
ENSG00000151694 E008 79.4396157 0.0006020667 5.483493e-01 6.782079e-01 2 9490359 9490518 160 - 1.812 1.873 0.206
ENSG00000151694 E009 44.0787536 0.0139897168 3.485003e-01 4.927298e-01 2 9491101 9491151 51 - 1.548 1.648 0.343
ENSG00000151694 E010 49.6685889 0.0004617423 8.043757e-01 8.755584e-01 2 9492898 9492986 89 - 1.621 1.639 0.062
ENSG00000151694 E011 0.7437457 0.0153787590 1.000000e+00 1.000000e+00 2 9492987 9493153 167 - 0.211 0.224 0.105
ENSG00000151694 E012 40.9751352 0.0042711991 6.322008e-01 7.470966e-01 2 9493747 9493788 42 - 1.544 1.541 -0.012
ENSG00000151694 E013 37.6903687 0.0005748869 4.656076e-01 6.052751e-01 2 9493789 9493825 37 - 1.514 1.497 -0.060
ENSG00000151694 E014 57.6195139 0.0091422246 4.053626e-01 5.490515e-01 2 9494637 9494767 131 - 1.669 1.759 0.305
ENSG00000151694 E015 2.4421882 0.0064951417 4.305967e-01 5.732181e-01 2 9497005 9497113 109 - 0.505 0.371 -0.700
ENSG00000151694 E016 55.3165678 0.0004573390 8.734586e-01 9.226735e-01 2 9497114 9497248 135 - 1.666 1.690 0.081
ENSG00000151694 E017 0.2966881 0.0270207750 1.000000e+00   2 9499207 9499437 231 - 0.118 0.000 -10.680
ENSG00000151694 E018 0.2998086 0.0285606909 3.131625e-01   2 9499438 9499491 54 - 0.063 0.224 2.104
ENSG00000151694 E019 6.7601367 0.0025146626 4.580508e-02 1.016759e-01 2 9499492 9501950 2459 - 0.732 1.020 1.108
ENSG00000151694 E020 0.7342825 0.0164423462 2.995467e-01 4.410747e-01 2 9501951 9502172 222 - 0.251 0.000 -12.001
ENSG00000151694 E021 46.9249327 0.0004691561 9.065092e-01 9.445927e-01 2 9502173 9502276 104 - 1.592 1.632 0.136
ENSG00000151694 E022 95.7972404 0.0018950748 7.446110e-02 1.506695e-01 2 9505166 9505365 200 - 1.915 1.861 -0.183
ENSG00000151694 E023 89.4695616 0.0013220319 5.049135e-06 3.590225e-05 2 9509979 9510131 153 - 1.912 1.707 -0.689
ENSG00000151694 E024 52.1410454 0.0004787281 3.765646e-08 4.159711e-07 2 9517901 9517989 89 - 1.702 1.354 -1.193
ENSG00000151694 E025 62.7565789 0.0010797235 3.297436e-03 1.114224e-02 2 9518103 9518247 145 - 1.751 1.611 -0.474
ENSG00000151694 E026 60.9140680 0.0003853969 3.925063e-02 8.963798e-02 2 9521203 9521316 114 - 1.729 1.646 -0.281
ENSG00000151694 E027 3.2378546 0.0154149562 5.089247e-01 6.443037e-01 2 9521317 9521321 5 - 0.582 0.481 -0.475
ENSG00000151694 E028 1.0987104 0.0904785154 7.389733e-01 8.287278e-01 2 9521322 9521595 274 - 0.288 0.225 -0.466
ENSG00000151694 E029 0.4375944 0.0272229479 6.219088e-01 7.388056e-01 2 9521596 9522438 843 - 0.167 0.000 -11.264
ENSG00000151694 E030 0.5827671 0.1334963403 4.655362e-01 6.052202e-01 2 9522439 9523248 810 - 0.211 0.000 -11.676
ENSG00000151694 E031 63.6036875 0.0003706605 1.388750e-02 3.797169e-02 2 9523249 9523338 90 - 1.750 1.646 -0.353
ENSG00000151694 E032 0.1482932 0.0406262647 1.069056e-01   2 9523339 9523348 10 - 0.000 0.224 13.615
ENSG00000151694 E033 69.6237038 0.0003868017 3.310434e-05 1.948524e-04 2 9526111 9526244 134 - 1.803 1.604 -0.675
ENSG00000151694 E034 2.0873122 0.0579797519 3.401580e-02 7.979137e-02 2 9526245 9526264 20 - 0.505 0.000 -13.489
ENSG00000151694 E035 0.1515154 0.0432987549 1.000000e+00   2 9527501 9527785 285 - 0.063 0.000 -9.680
ENSG00000151694 E036 67.3840384 0.0004293064 1.526868e-06 1.218812e-05 2 9527786 9527954 169 - 1.797 1.550 -0.839
ENSG00000151694 E037 0.1451727 0.0436179947 1.000000e+00   2 9529488 9529804 317 - 0.063 0.000 -9.679
ENSG00000151694 E038 47.6298158 0.0027295736 2.342234e-04 1.109406e-03 2 9535834 9535922 89 - 1.649 1.414 -0.804
ENSG00000151694 E039 56.3599852 0.0024819393 6.161188e-05 3.393768e-04 2 9536698 9536828 131 - 1.722 1.487 -0.803
ENSG00000151694 E040 0.0000000       2 9538058 9538077 20 -      
ENSG00000151694 E041 36.5111536 0.0005781740 9.954179e-04 3.942115e-03 2 9543153 9543220 68 - 1.535 1.314 -0.763
ENSG00000151694 E042 22.4705405 0.0009035364 1.035251e-02 2.963333e-02 2 9543221 9543226 6 - 1.333 1.119 -0.757
ENSG00000151694 E043 32.2826814 0.0015259030 4.968383e-03 1.584108e-02 2 9543227 9543285 59 - 1.482 1.284 -0.686
ENSG00000151694 E044 0.0000000       2 9543696 9543760 65 -      
ENSG00000151694 E045 0.0000000       2 9551475 9551757 283 -      
ENSG00000151694 E046 0.0000000       2 9554709 9554729 21 -      
ENSG00000151694 E047 49.1744810 0.0066967047 1.733121e-03 6.387088e-03 2 9555509 9555830 322 - 1.660 1.447 -0.727
ENSG00000151694 E048 0.0000000       2 9556591 9556732 142 -