ENSG00000151693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281419 ENSG00000151693 HEK293_OSMI2_2hA HEK293_TMG_2hB ASAP2 protein_coding protein_coding 3.917175 2.184045 5.736722 0.1551551 0.1496584 1.389146 0.4656787 0.09224985 1.16297907 0.05842583 0.46855931 3.520007 0.1236542 0.03903333 0.206533333 0.16750000 0.1571091054 0.0001703475 FALSE TRUE
ENST00000315273 ENSG00000151693 HEK293_OSMI2_2hA HEK293_TMG_2hB ASAP2 protein_coding protein_coding 3.917175 2.184045 5.736722 0.1551551 0.1496584 1.389146 2.9205805 1.45848983 4.40955094 0.19875601 0.60366879 1.589567 0.7086208 0.68263333 0.764666667 0.08203333 0.8708366531 0.0001703475 FALSE TRUE
ENST00000484590 ENSG00000151693 HEK293_OSMI2_2hA HEK293_TMG_2hB ASAP2 protein_coding retained_intron 3.917175 2.184045 5.736722 0.1551551 0.1496584 1.389146 0.2336603 0.54357912 0.02590337 0.21220473 0.01610526 -3.946598 0.1038583 0.24223333 0.004566667 -0.23766667 0.0001703475 0.0001703475 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151693 E001 0.4396707 0.0263702303 4.609546e-01 6.009336e-01 2 9206765 9206811 47 + 0.171 0.000 -8.977
ENSG00000151693 E002 16.5492663 0.0011002526 3.049666e-02 7.294218e-02 2 9206812 9207230 419 + 1.198 1.087 -0.398
ENSG00000151693 E003 13.7362705 0.0019037082 1.692988e-03 6.260375e-03 2 9279317 9279389 73 + 1.146 0.881 -0.980
ENSG00000151693 E004 26.5004124 0.0150586562 1.121211e-03 4.374486e-03 2 9297300 9297445 146 + 1.408 1.173 -0.824
ENSG00000151693 E005 18.0190252 0.0009965499 2.075925e-03 7.459462e-03 2 9318524 9318598 75 + 1.244 1.037 -0.741
ENSG00000151693 E006 17.1867373 0.0010997498 1.862455e-02 4.850652e-02 2 9320288 9320337 50 + 1.215 1.087 -0.460
ENSG00000151693 E007 26.1545744 0.0029292123 7.431982e-04 3.054754e-03 2 9323121 9323250 130 + 1.397 1.209 -0.658
ENSG00000151693 E008 20.6938802 0.0028742276 4.510047e-07 4.024564e-06 2 9327826 9327911 86 + 1.330 0.881 -1.628
ENSG00000151693 E009 24.6537167 0.0008279953 4.163900e-04 1.837285e-03 2 9334738 9334813 76 + 1.374 1.172 -0.709
ENSG00000151693 E010 29.6769073 0.0007049410 8.977187e-04 3.606236e-03 2 9335093 9335179 87 + 1.442 1.289 -0.529
ENSG00000151693 E011 0.0000000       2 9336036 9336044 9 +      
ENSG00000151693 E012 29.1484044 0.0022249203 3.364683e-03 1.133570e-02 2 9344532 9344635 104 + 1.432 1.304 -0.443
ENSG00000151693 E013 23.3878201 0.0051787258 4.761075e-02 1.049268e-01 2 9344731 9344800 70 + 1.330 1.259 -0.250
ENSG00000151693 E014 1.1813256 0.0826583813 7.843822e-01 8.616874e-01 2 9350459 9350807 349 + 0.256 0.368 0.733
ENSG00000151693 E015 25.3344062 0.0008065876 1.131089e-01 2.100694e-01 2 9350808 9350895 88 + 1.349 1.331 -0.062
ENSG00000151693 E016 19.5104239 0.0010286201 1.953018e-01 3.203489e-01 2 9356047 9356095 49 + 1.236 1.226 -0.034
ENSG00000151693 E017 35.6651750 0.0026092476 7.676403e-01 8.498399e-01 2 9356179 9356345 167 + 1.466 1.556 0.309
ENSG00000151693 E018 32.3144252 0.0006962532 2.347171e-02 5.872597e-02 2 9358756 9358889 134 + 1.459 1.405 -0.187
ENSG00000151693 E019 31.3512724 0.0006306618 5.775020e-03 1.802109e-02 2 9368425 9368519 95 + 1.454 1.357 -0.335
ENSG00000151693 E020 40.0674708 0.0006025005 1.399190e-03 5.304419e-03 2 9374755 9374944 190 + 1.560 1.458 -0.351
ENSG00000151693 E021 22.6087191 0.0049899578 4.236920e-01 5.667430e-01 2 9376908 9376993 86 + 1.293 1.331 0.135
ENSG00000151693 E022 30.1403887 0.0227264593 6.786680e-01 7.830827e-01 2 9378944 9379059 116 + 1.402 1.478 0.261
ENSG00000151693 E023 24.8286568 0.0008254994 1.322106e-01 2.371820e-01 2 9380741 9380808 68 + 1.343 1.331 -0.041
ENSG00000151693 E024 33.5356373 0.0006361226 3.144629e-01 4.571753e-01 2 9385245 9385358 114 + 1.454 1.496 0.144
ENSG00000151693 E025 22.9843997 0.0008916034 1.666897e-02 4.421201e-02 2 9388294 9388546 253 + 1.224 1.514 1.008
ENSG00000151693 E026 2.5247903 0.0079646139 6.141614e-01 7.327116e-01 2 9391062 9391196 135 + 0.490 0.474 -0.077
ENSG00000151693 E027 17.1025397 0.0177826796 1.749514e-01 2.946082e-01 2 9393482 9393647 166 + 1.121 1.377 0.903
ENSG00000151693 E028 1.1081987 0.0133792857 6.592979e-02 1.365840e-01 2 9398841 9400022 1182 + 0.171 0.560 2.451
ENSG00000151693 E029 14.7236603 0.0078668422 1.391144e-01 2.468441e-01 2 9400023 9400072 50 + 1.141 1.086 -0.200
ENSG00000151693 E030 20.5242226 0.0009234993 2.744397e-01 4.135915e-01 2 9400742 9400830 89 + 1.207 1.405 0.693
ENSG00000151693 E031 33.0081027 0.0007602006 6.555312e-01 7.654140e-01 2 9401274 9401396 123 + 1.442 1.522 0.277
ENSG00000151693 E032 271.9117296 0.0188927525 3.662178e-09 4.887212e-08 2 9403253 9405683 2431 + 2.229 2.635 1.353