ENSG00000151692

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320892 ENSG00000151692 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF144A protein_coding protein_coding 2.823255 2.653494 3.716534 0.1423018 0.02714898 0.4845144 2.5933124 2.54898341 3.2272096 0.13442834 0.03331948 0.339180 0.92208750 0.9610667 0.8684667 -0.09260000 0.01441755 0.01441755 FALSE  
MSTRG.17903.2 ENSG00000151692 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF144A protein_coding   2.823255 2.653494 3.716534 0.1423018 0.02714898 0.4845144 0.1790763 0.08573155 0.3991398 0.02578496 0.04400584 2.095528 0.06007083 0.0320000 0.1075333 0.07553333 0.01894114 0.01441755 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151692 E001 2.2810932 0.012895428 2.131634e-01 3.422708e-01 2 6917412 6917479 68 + 0.563 0.414 -0.736
ENSG00000151692 E002 3.0476410 0.065006268 1.637007e-01 2.799528e-01 2 6917480 6917488 9 + 0.674 0.479 -0.885
ENSG00000151692 E003 9.5629519 0.037377792 3.258664e-02 7.697655e-02 2 6917489 6917622 134 + 1.103 0.892 -0.783
ENSG00000151692 E004 0.0000000       2 6933043 6933083 41 +      
ENSG00000151692 E005 0.0000000       2 6933084 6933230 147 +      
ENSG00000151692 E006 23.9590157 0.000908007 9.325291e-04 3.728173e-03 2 6940948 6941147 200 + 1.453 1.312 -0.489
ENSG00000151692 E007 0.0000000       2 6978624 6978839 216 +      
ENSG00000151692 E008 0.0000000       2 6996749 6996915 167 +      
ENSG00000151692 E009 9.9059693 0.007452695 5.187609e-01 6.529733e-01 2 6996916 6996939 24 + 1.024 1.040 0.058
ENSG00000151692 E010 19.1918664 0.001306244 5.425423e-02 1.166941e-01 2 6996940 6997061 122 + 1.327 1.268 -0.206
ENSG00000151692 E011 17.5542260 0.001192121 7.710265e-04 3.153809e-03 2 7014454 7014558 105 + 1.337 1.151 -0.658
ENSG00000151692 E012 11.8508912 0.001504751 3.466534e-02 8.100909e-02 2 7014712 7014772 61 + 1.155 1.040 -0.418
ENSG00000151692 E013 21.5902845 0.016995781 8.743239e-02 1.712465e-01 2 7020473 7020680 208 + 1.383 1.312 -0.245
ENSG00000151692 E014 0.4804688 0.022174330 6.833858e-01 7.865838e-01 2 7020681 7020768 88 + 0.185 0.146 -0.417
ENSG00000151692 E015 19.3719742 0.003128189 2.943480e-02 7.084388e-02 2 7024369 7024516 148 + 1.343 1.258 -0.295
ENSG00000151692 E016 15.6750337 0.021556018 4.047878e-02 9.189876e-02 2 7030126 7030215 90 + 1.280 1.147 -0.473
ENSG00000151692 E017 17.9529231 0.014220570 5.783575e-01 7.034689e-01 2 7039629 7039799 171 + 1.262 1.294 0.113
ENSG00000151692 E018 367.7511341 0.008899648 1.716955e-06 1.354865e-05 2 7039800 7044179 4380 + 2.476 2.655 0.597
ENSG00000151692 E019 0.4782907 0.021768165 5.989797e-02 1.264352e-01 2 7045356 7045430 75 + 0.000 0.341 11.158
ENSG00000151692 E020 0.0000000       2 7068216 7068286 71 +