ENSG00000151690

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281416 ENSG00000151690 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD6 protein_coding protein_coding 0.6965175 0.4742648 1.444675 0.08058265 0.106176 1.586828 0.33013538 0.3147223 0.1587263 0.05176736 0.08424712 -0.9445215 0.59702083 0.7061667 0.1077333 -0.59843333 0.1082685205 0.0001535993 FALSE TRUE
ENST00000392328 ENSG00000151690 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD6 protein_coding protein_coding 0.6965175 0.4742648 1.444675 0.08058265 0.106176 1.586828 0.09992397 0.0000000 0.1642957 0.00000000 0.09407335 4.1234653 0.12815833 0.0000000 0.1105667 0.11056667 0.4548252216 0.0001535993 FALSE TRUE
ENST00000432036 ENSG00000151690 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD6 protein_coding protein_coding 0.6965175 0.4742648 1.444675 0.08058265 0.106176 1.586828 0.08521374 0.0000000 0.5519940 0.00000000 0.11186881 5.8124829 0.06148333 0.0000000 0.3801667 0.38016667 0.0001535993 0.0001535993 FALSE TRUE
ENST00000434582 ENSG00000151690 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD6 protein_coding protein_coding 0.6965175 0.4742648 1.444675 0.08058265 0.106176 1.586828 0.11549570 0.1595426 0.2853222 0.10814068 0.14837771 0.8006422 0.15467917 0.2938333 0.2143000 -0.07953333 0.9276976616 0.0001535993 FALSE TRUE
ENST00000444317 ENSG00000151690 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD6 protein_coding protein_coding 0.6965175 0.4742648 1.444675 0.08058265 0.106176 1.586828 0.04789392 0.0000000 0.2843364 0.00000000 0.17836709 4.8793940 0.03766667 0.0000000 0.1872333 0.18723333 0.4174330328 0.0001535993 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151690 E001 1.1739533 0.012198908 1.825498e-02 4.768758e-02 2 190408355 190408503 149 + 0.438 0.001 -10.509
ENSG00000151690 E002 0.2924217 0.029078516 4.422007e-01   2 190415292 190415413 122 + 0.157 0.000 -9.987
ENSG00000151690 E003 0.0000000       2 190433327 190433392 66 +      
ENSG00000151690 E004 0.0000000       2 190435301 190435329 29 +      
ENSG00000151690 E005 0.0000000       2 190435895 190435976 82 +      
ENSG00000151690 E006 20.0221462 0.002706566 1.772216e-02 4.653697e-02 2 190435977 190437423 1447 + 1.340 1.232 -0.378
ENSG00000151690 E007 2.2916151 0.007352210 9.196923e-01 9.532699e-01 2 190437424 190437561 138 + 0.502 0.535 0.160
ENSG00000151690 E008 0.0000000       2 190442576 190443005 430 +      
ENSG00000151690 E009 0.0000000       2 190469493 190469649 157 +      
ENSG00000151690 E010 2.8224234 0.027223767 7.459446e-02 1.508862e-01 2 190469758 190469855 98 + 0.652 0.390 -1.261
ENSG00000151690 E011 4.7777986 0.032057505 3.607530e-02 8.373078e-02 2 190488657 190488818 162 + 0.824 0.536 -1.216
ENSG00000151690 E012 3.3570041 0.005124178 5.170418e-03 1.639145e-02 2 190489768 190489819 52 + 0.728 0.295 -2.159
ENSG00000151690 E013 3.3527377 0.005797879 5.291496e-03 1.672548e-02 2 190489820 190489866 47 + 0.728 0.295 -2.159
ENSG00000151690 E014 6.3796424 0.010888481 2.232915e-04 1.063209e-03 2 190497439 190497648 210 + 0.967 0.470 -2.084
ENSG00000151690 E015 3.1687535 0.008016960 2.885650e-01 4.291613e-01 2 190497649 190497719 71 + 0.651 0.535 -0.518
ENSG00000151690 E016 0.0000000       2 190497720 190497995 276 +      
ENSG00000151690 E017 0.0000000       2 190499832 190499856 25 +      
ENSG00000151690 E018 4.5320084 0.006845254 6.039376e-01 7.246126e-01 2 190500015 190500276 262 + 0.672 0.803 0.535
ENSG00000151690 E019 36.3092042 0.023536137 1.135624e-09 1.666384e-08 2 190500277 190502315 2039 + 1.336 1.784 1.534
ENSG00000151690 E020 0.0000000       2 190504996 190505121 126 +      
ENSG00000151690 E021 0.0000000       2 190509163 190509205 43 +