ENSG00000151689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322522 ENSG00000151689 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP1 protein_coding protein_coding 4.26531 5.921306 3.052316 0.516255 0.3792775 -0.9537266 2.9581612 4.80670659 1.6838398 0.26943518 0.2903101 -1.5077496 0.6764792 0.816200000 0.56393333 -0.2522667 0.06562507 0.02208381 FALSE TRUE
ENST00000392329 ENSG00000151689 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP1 protein_coding protein_coding 4.26531 5.921306 3.052316 0.516255 0.3792775 -0.9537266 0.6554444 0.54234271 0.7969506 0.20223702 0.0520502 0.5469166 0.1703958 0.088300000 0.27270000 0.1844000 0.02208381 0.02208381 FALSE TRUE
ENST00000458647 ENSG00000151689 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP1 protein_coding protein_coding 4.26531 5.921306 3.052316 0.516255 0.3792775 -0.9537266 0.1083163 0.05540644 0.3155556 0.05540644 0.3155556 2.3153992 0.0262875 0.008066667 0.08616667 0.0781000 0.93264664 0.02208381 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151689 E001 0.2214452 0.0411976692 1.0000000000   2 190343570 190343588 19 + 0.000 0.084 7.643
ENSG00000151689 E002 1.7757591 0.0086001831 0.0042489808 0.013839189 2 190343589 190343646 58 + 0.696 0.215 -2.627
ENSG00000151689 E003 10.8467528 0.0019057628 0.0147652673 0.039962180 2 190343647 190343874 228 + 1.187 0.939 -0.901
ENSG00000151689 E004 8.8079046 0.0646471180 0.4414309999 0.583072655 2 190343875 190343907 33 + 1.017 0.901 -0.433
ENSG00000151689 E005 9.0292612 0.0323223059 0.7760042631 0.855763896 2 190343908 190343917 10 + 0.974 0.932 -0.156
ENSG00000151689 E006 10.7894902 0.0274901725 0.5122967047 0.647197758 2 190343918 190343929 12 + 1.076 0.992 -0.308
ENSG00000151689 E007 10.9012648 0.0120577057 0.3784263198 0.522717357 2 190343930 190343941 12 + 1.093 0.990 -0.377
ENSG00000151689 E008 12.2235218 0.0041438507 0.2014551935 0.327999880 2 190343942 190343961 20 + 1.158 1.026 -0.475
ENSG00000151689 E009 1.5165320 0.0091320969 0.5977575230 0.719477728 2 190343962 190344074 113 + 0.299 0.397 0.593
ENSG00000151689 E010 0.8512514 0.0144023732 0.6131800641 0.731948566 2 190344075 190344078 4 + 0.175 0.268 0.786
ENSG00000151689 E011 0.5106578 0.3276522902 0.9058202524 0.944108456 2 190344079 190344163 85 + 0.175 0.155 -0.203
ENSG00000151689 E012 0.5106578 0.3276522902 0.9058202524 0.944108456 2 190344164 190344218 55 + 0.175 0.155 -0.203
ENSG00000151689 E013 0.5848540 0.1339695190 0.3184371028 0.461409261 2 190345505 190345575 71 + 0.000 0.217 10.715
ENSG00000151689 E014 5.9366927 0.0028337968 0.0027448123 0.009506508 2 190348888 190349031 144 + 1.038 0.666 -1.448
ENSG00000151689 E015 0.0000000       2 190356517 190356535 19 +      
ENSG00000151689 E016 0.0000000       2 190356536 190356617 82 +      
ENSG00000151689 E017 0.0000000       2 190356618 190356808 191 +      
ENSG00000151689 E018 0.0000000       2 190359646 190359698 53 +      
ENSG00000151689 E019 0.0000000       2 190360018 190360038 21 +      
ENSG00000151689 E020 49.8469782 0.0006363068 0.0014591569 0.005504439 2 190360039 190360306 268 + 1.767 1.612 -0.525
ENSG00000151689 E021 24.8313971 0.0009261157 0.2011031335 0.327561799 2 190362627 190362687 61 + 1.436 1.345 -0.313
ENSG00000151689 E022 1.2136054 0.0109659380 0.0098288084 0.028342820 2 190362688 190363007 320 + 0.599 0.155 -2.798
ENSG00000151689 E023 0.6224193 0.0184089704 0.4117579107 0.555307735 2 190365113 190365152 40 + 0.299 0.154 -1.214
ENSG00000151689 E024 47.5409029 0.0006342313 0.1349842886 0.241073640 2 190366695 190366895 201 + 1.582 1.661 0.271
ENSG00000151689 E025 0.3697384 0.0274424043 0.5398084587 0.671039601 2 190368644 190369102 459 + 0.000 0.155 10.468
ENSG00000151689 E026 48.8424501 0.0006380069 0.0008269552 0.003355915 2 190369103 190369277 175 + 1.508 1.692 0.628
ENSG00000151689 E027 121.2114947 0.0006216647 0.0002996347 0.001378123 2 190370844 190371665 822 + 1.955 2.066 0.373