ENSG00000151687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313581 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding protein_coding 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.01712839 0.0000000 0.04249744 0.00000000 0.021352158 2.3922469 0.01247917 0.0000000 0.05090000 0.05090000 0.73055382 0.03403511 FALSE TRUE
ENST00000441800 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding nonsense_mediated_decay 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.22026789 0.1237744 0.27676567 0.01084949 0.011769941 1.1000702 0.31400000 0.5780000 0.33430000 -0.24370000 0.41014056 0.03403511 TRUE TRUE
ENST00000461516 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding processed_transcript 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.37841073 0.1044695 0.15103539 0.05225559 0.075956758 0.4924142 0.33237083 0.3748667 0.17423333 -0.20063333 0.65446559 0.03403511 FALSE FALSE
ENST00000464687 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding processed_transcript 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.16484593 0.0000000 0.18987965 0.00000000 0.009682614 4.3210597 0.12317083 0.0000000 0.22956667 0.22956667 0.03403511 0.03403511   FALSE
ENST00000467927 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding retained_intron 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.03463647 0.0000000 0.07024590 0.00000000 0.018946664 3.0044276 0.04432917 0.0000000 0.08266667 0.08266667 0.41806376 0.03403511 FALSE TRUE
ENST00000474303 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding processed_transcript 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.04734593 0.0000000 0.06749350 0.00000000 0.067493495 2.9540752 0.04433333 0.0000000 0.08940000 0.08940000 1.00000000 0.03403511 FALSE TRUE
ENST00000476208 ENSG00000151687 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKAR protein_coding processed_transcript 1.017352 0.2350972 0.829526 0.04652617 0.04917404 1.776221 0.08661500 0.0000000 0.00000000 0.00000000 0.000000000 0.0000000 0.07049583 0.0000000 0.00000000 0.00000000   0.03403511   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151687 E001 18.8232116 0.001236018 1.532831e-01 2.661421e-01 2 189674290 189674606 317 + 1.251 1.334 0.291
ENSG00000151687 E002 7.9547100 0.002601553 6.354622e-01 7.497720e-01 2 189674607 189674669 63 + 0.922 0.958 0.134
ENSG00000151687 E003 15.9595653 0.001316831 4.090771e-02 9.271589e-02 2 189674670 189674830 161 + 1.150 1.291 0.499
ENSG00000151687 E004 11.4461744 0.002260947 8.593657e-09 1.072421e-07 2 189675985 189676037 53 + 0.778 1.309 1.955
ENSG00000151687 E005 0.0000000       2 189676427 189676455 29 +      
ENSG00000151687 E006 0.0000000       2 189676456 189676937 482 +      
ENSG00000151687 E007 0.1515154 0.043622202 7.471782e-01   2 189676938 189677091 154 + 0.101 0.000 -12.272
ENSG00000151687 E008 3.7288188 0.005311773 1.960328e-02 5.063514e-02 2 189689527 189689964 438 + 0.796 0.417 -1.703
ENSG00000151687 E009 0.2944980 0.250566536 4.309392e-01   2 189692255 189692418 164 + 0.183 0.000 -12.898
ENSG00000151687 E010 0.4439371 0.021819843 1.830021e-01 3.049504e-01 2 189692419 189692849 431 + 0.252 0.000 -13.649
ENSG00000151687 E011 1.5166363 0.009272812 2.110190e-01 3.397375e-01 2 189693074 189693177 104 + 0.492 0.257 -1.383
ENSG00000151687 E012 0.6653823 0.017317598 5.752096e-01 7.008852e-01 2 189694981 189695161 181 + 0.252 0.147 -0.965
ENSG00000151687 E013 2.8494773 0.005746056 1.409286e-01 2.492973e-01 2 189696150 189696300 151 + 0.670 0.417 -1.189
ENSG00000151687 E014 2.2959702 0.009496063 1.250654e-01 2.272299e-01 2 189696301 189696369 69 + 0.618 0.344 -1.383
ENSG00000151687 E015 2.6300187 0.011048548 8.261222e-01 8.905818e-01 2 189705023 189705224 202 + 0.560 0.582 0.100
ENSG00000151687 E016 3.2452546 0.004874942 5.391748e-02 1.161175e-01 2 189706938 189707146 209 + 0.738 0.417 -1.469
ENSG00000151687 E017 0.1817044 0.042052892 3.084847e-01   2 189711049 189711153 105 + 0.000 0.147 12.216
ENSG00000151687 E018 1.9584825 0.007730761 3.258118e-01 4.692454e-01 2 189719572 189719813 242 + 0.527 0.345 -0.966
ENSG00000151687 E019 1.7047721 0.008644272 2.721441e-02 6.642815e-02 2 189720619 189720787 169 + 0.560 0.147 -2.703
ENSG00000151687 E020 0.1515154 0.043622202 7.471782e-01   2 189727823 189727855 33 + 0.101 0.000 -12.272
ENSG00000151687 E021 2.1088666 0.007301625 1.730875e-01 2.921969e-01 2 189727856 189728097 242 + 0.590 0.344 -1.258
ENSG00000151687 E022 1.3714636 0.010247554 3.009753e-01 4.427550e-01 2 189728267 189728352 86 + 0.453 0.257 -1.191
ENSG00000151687 E023 1.0769655 0.014079129 5.859880e-01 7.096291e-01 2 189728353 189728420 68 + 0.364 0.257 -0.706
ENSG00000151687 E024 1.0392880 0.013277603 5.842151e-01 7.081747e-01 2 189728660 189728821 162 + 0.364 0.256 -0.707
ENSG00000151687 E025 0.0000000       2 189730495 189730601 107 +      
ENSG00000151687 E026 0.5827671 0.129551884 1.257985e-01 2.282839e-01 2 189733107 189733229 123 + 0.311 0.000 -13.853
ENSG00000151687 E027 2.1035680 0.007315473 4.383156e-01 5.802064e-01 2 189737683 189737841 159 + 0.560 0.417 -0.706
ENSG00000151687 E028 0.0000000       2 189738559 189738564 6 +      
ENSG00000151687 E029 1.5049830 0.011161307 4.386962e-02 9.814558e-02 2 189738565 189738682 118 + 0.527 0.147 -2.552
ENSG00000151687 E030 1.2104850 0.011530060 1.049959e-01 1.980935e-01 2 189741342 189741451 110 + 0.453 0.147 -2.189
ENSG00000151687 E031 0.0000000       2 189743275 189743474 200 +      
ENSG00000151687 E032 0.4418608 0.027784730 1.841087e-01 3.063821e-01 2 189744742 189744788 47 + 0.252 0.000 -13.642
ENSG00000151687 E033 0.8021360 0.659323377 7.584698e-01 8.430642e-01 2 189746380 189746650 271 + 0.310 0.152 -1.311
ENSG00000151687 E034 0.8157519 0.016051798 9.443308e-01 9.691153e-01 2 189752935 189753140 206 + 0.252 0.257 0.033
ENSG00000151687 E035 0.2903454 0.322095865 4.495882e-01   2 189761098 189761193 96 + 0.183 0.000 -12.815