ENSG00000151612

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503462 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding protein_coding 1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.45647095 0.20078614 0.68265724 0.10070885 0.34563640 1.716361590 0.26447500 0.19936667 0.37520000 0.17583333 0.86866214 0.00521509 FALSE TRUE
ENST00000508784 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding protein_coding 1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.22639010 0.16252712 0.29354098 0.04163940 0.20977856 0.815068157 0.13272500 0.14316667 0.16576667 0.02260000 0.91669671 0.00521509 FALSE TRUE
ENST00000515386 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding retained_intron 1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.17496256 0.02028178 0.12670642 0.02028178 0.01000578 2.174558808 0.08422500 0.01600000 0.06993333 0.05393333 0.26358993 0.00521509 FALSE TRUE
ENST00000655597 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding protein_coding 1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.24498159 0.13805005 0.13874526 0.10404138 0.13874526 0.006758766 0.14441250 0.11153333 0.07693333 -0.03460000 0.73219399 0.00521509 FALSE TRUE
ENST00000671983 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding retained_intron 1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.16369982 0.04996632 0.14309702 0.02121349 0.03581283 1.352221777 0.08432500 0.04246667 0.08136667 0.03890000 0.68226694 0.00521509 FALSE TRUE
ENST00000673178 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding nonsense_mediated_decay 1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.29544451 0.51887056 0.06062832 0.01302096 0.06062832 -2.904595937 0.18597917 0.47746667 0.03666667 -0.44080000 0.00521509 0.00521509 TRUE TRUE
MSTRG.25545.7 ENSG00000151612 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF827 protein_coding   1.785178 1.102478 1.814102 0.09843695 0.09563202 0.7134097 0.02009282 0.00000000 0.16074253 0.00000000 0.12816714 4.093750549 0.01026667 0.00000000 0.08213333 0.08213333 0.40338046 0.00521509 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151612 E001 0.6664265 0.0178024029 6.977534e-01 7.978084e-01 4 145757627 145757663 37 - 0.186 0.254 0.569
ENSG00000151612 E002 0.8147197 0.0158607663 3.814359e-01 5.257355e-01 4 145757664 145757664 1 - 0.186 0.340 1.153
ENSG00000151612 E003 40.5174705 0.0034858576 1.423160e-11 2.889746e-10 4 145757665 145758534 870 - 1.394 1.787 1.342
ENSG00000151612 E004 26.8194950 0.0009585343 1.349162e-04 6.808050e-04 4 145758535 145759006 472 - 1.317 1.564 0.851
ENSG00000151612 E005 32.2849187 0.0023722384 4.882619e-07 4.325653e-06 4 145759007 145759698 692 - 1.344 1.658 1.076
ENSG00000151612 E006 39.8242950 0.0008723806 2.691602e-03 9.349052e-03 4 145759699 145760720 1022 - 1.523 1.683 0.546
ENSG00000151612 E007 3.1741894 0.0050464196 6.305390e-01 7.457161e-01 4 145760721 145760728 8 - 0.651 0.577 -0.324
ENSG00000151612 E008 3.2763990 0.0059667697 8.369739e-01 8.980458e-01 4 145760729 145760737 9 - 0.651 0.620 -0.132
ENSG00000151612 E009 3.7611212 0.0043000906 7.804420e-01 8.588979e-01 4 145760738 145760750 13 - 0.700 0.659 -0.169
ENSG00000151612 E010 3.7611212 0.0043000906 7.804420e-01 8.588979e-01 4 145760751 145760762 12 - 0.700 0.659 -0.169
ENSG00000151612 E011 3.4623567 0.0046996801 9.550256e-01 9.757721e-01 4 145760763 145760764 2 - 0.651 0.659 0.038
ENSG00000151612 E012 3.9073380 0.0040849821 9.742685e-01 9.879525e-01 4 145760765 145760774 10 - 0.700 0.696 -0.017
ENSG00000151612 E013 26.2503398 0.0009411724 3.739928e-01 5.184125e-01 4 145760775 145761598 824 - 1.459 1.401 -0.201
ENSG00000151612 E014 4.3610411 0.0385938127 3.245687e-01 4.679460e-01 4 145761599 145763089 1491 - 0.784 0.623 -0.669
ENSG00000151612 E015 0.6966155 0.0167571902 1.631003e-01 2.791905e-01 4 145763090 145763117 28 - 0.103 0.340 2.155
ENSG00000151612 E016 0.3634088 0.3115855161 1.708237e-01   4 145763118 145763122 5 - 0.000 0.255 13.019
ENSG00000151612 E017 0.6277178 0.0202888142 5.291428e-01 6.619640e-01 4 145763123 145763222 100 - 0.256 0.145 -1.016
ENSG00000151612 E018 1.7254080 0.1860746055 7.191856e-01 8.140890e-01 4 145763402 145763468 67 - 0.415 0.471 0.292
ENSG00000151612 E019 0.7708142 0.0154760585 3.392899e-01 4.831838e-01 4 145764689 145764974 286 - 0.316 0.145 -1.431
ENSG00000151612 E020 0.5891098 0.0184905821 8.569845e-02 1.685088e-01 4 145764975 145764978 4 - 0.316 0.000 -14.698
ENSG00000151612 E021 0.8794552 0.0632779745 3.202913e-02 7.591271e-02 4 145764979 145764987 9 - 0.415 0.000 -15.070
ENSG00000151612 E022 7.7206318 0.0333605359 8.466541e-01 9.046847e-01 4 145764988 145765165 178 - 0.955 0.928 -0.100
ENSG00000151612 E023 10.9712907 0.0025339666 1.285091e-03 4.927044e-03 4 145765547 145765738 192 - 1.203 0.865 -1.240
ENSG00000151612 E024 9.7128704 0.0017651898 3.478215e-02 8.122894e-02 4 145774506 145774672 167 - 1.115 0.889 -0.835
ENSG00000151612 E025 8.9252286 0.0021469323 3.301793e-01 4.737600e-01 4 145775789 145775960 172 - 1.037 0.931 -0.392
ENSG00000151612 E026 8.4425472 0.0020806683 1.251123e-02 3.476205e-02 4 145779374 145779511 138 - 1.078 0.789 -1.088
ENSG00000151612 E027 0.0000000       4 145819838 145820096 259 -      
ENSG00000151612 E028 8.7746222 0.0032468089 7.868238e-03 2.344950e-02 4 145823422 145823525 104 - 1.097 0.789 -1.156
ENSG00000151612 E029 0.1451727 0.0430208802 6.974749e-01   4 145823722 145823925 204 - 0.103 0.000 -12.916
ENSG00000151612 E030 4.9122589 0.0049510361 9.671869e-02 1.854600e-01 4 145845956 145846013 58 - 0.854 0.620 -0.954
ENSG00000151612 E031 3.0375139 0.0053205829 2.695659e-03 9.360911e-03 4 145849322 145849350 29 - 0.764 0.254 -2.601
ENSG00000151612 E032 11.0507178 0.0026779999 3.067536e-01 4.489370e-01 4 145849351 145849561 211 - 1.124 1.022 -0.370
ENSG00000151612 E033 0.0000000       4 145861372 145862006 635 -      
ENSG00000151612 E034 7.1537214 0.0024309799 8.260237e-01 8.905089e-01 4 145870245 145870300 56 - 0.915 0.889 -0.098
ENSG00000151612 E035 12.8775809 0.0013427807 1.274348e-01 2.305774e-01 4 145870301 145870478 178 - 1.196 1.053 -0.512
ENSG00000151612 E036 0.0000000       4 145870719 145870767 49 -      
ENSG00000151612 E037 0.0000000       4 145872142 145872212 71 -      
ENSG00000151612 E038 0.3634088 0.3115855161 1.708237e-01   4 145874175 145876858 2684 - 0.000 0.255 13.019
ENSG00000151612 E039 15.6488006 0.0011481600 5.613709e-04 2.389888e-03 4 145885678 145886032 355 - 1.329 1.022 -1.094
ENSG00000151612 E040 9.3334308 0.0061789404 3.223960e-04 1.470458e-03 4 145886033 145886158 126 - 1.157 0.729 -1.616
ENSG00000151612 E041 7.2583676 0.0058743938 1.825449e-03 6.681593e-03 4 145892243 145892409 167 - 1.058 0.659 -1.549
ENSG00000151612 E042 1.9198891 0.0127513626 8.697239e-03 2.552977e-02 4 145892410 145892415 6 - 0.624 0.145 -3.017
ENSG00000151612 E043 0.0000000       4 145898364 145898769 406 -      
ENSG00000151612 E044 16.3219442 0.0012260494 2.583384e-02 6.359829e-02 4 145902166 145902927 762 - 1.312 1.123 -0.667
ENSG00000151612 E045 9.0709883 0.0205985834 8.181970e-01 8.851003e-01 4 145902928 145903215 288 - 0.992 1.020 0.105
ENSG00000151612 E046 0.1515154 0.0426155480 6.972179e-01   4 145904218 145904302 85 - 0.103 0.000 -12.918
ENSG00000151612 E047 0.2966881 0.0290785164 3.302530e-01   4 145908340 145909198 859 - 0.186 0.000 -13.843
ENSG00000151612 E048 0.1451727 0.0430208802 6.974749e-01   4 145909199 145909339 141 - 0.103 0.000 -12.916
ENSG00000151612 E049 0.2966881 0.0290785164 3.302530e-01   4 145909340 145909855 516 - 0.186 0.000 -13.843
ENSG00000151612 E050 1.3047535 0.1061591044 9.209041e-01 9.541083e-01 4 145909856 145913307 3452 - 0.369 0.341 -0.168
ENSG00000151612 E051 0.4396707 0.0252281236 1.645156e-01 2.810444e-01 4 145936036 145936189 154 - 0.256 0.000 -14.347
ENSG00000151612 E052 6.6534718 0.0026365248 7.716322e-01 8.526051e-01 4 145938365 145938823 459 - 0.900 0.866 -0.132