ENSG00000151576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281273 ENSG00000151576 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT2 protein_coding protein_coding 27.67637 17.39537 38.32592 1.858012 0.4178395 1.139164 8.839463 3.721492 13.5096590 0.2102895 0.982124551 1.857234 0.29332917 0.21663333 0.35303333 0.13640000 8.756351e-03 8.421218e-15 FALSE TRUE
ENST00000462966 ENSG00000151576 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT2 protein_coding protein_coding 27.67637 17.39537 38.32592 1.858012 0.4178395 1.139164 1.414116 3.446687 0.0000000 1.9324204 0.000000000 -8.433246 0.08284583 0.18220000 0.00000000 -0.18220000 9.532539e-02 8.421218e-15 FALSE FALSE
ENST00000483272 ENSG00000151576 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT2 protein_coding retained_intron 27.67637 17.39537 38.32592 1.858012 0.4178395 1.139164 1.715827 3.195881 1.3799421 0.3519843 0.379237348 -1.205696 0.08614167 0.18980000 0.03596667 -0.15383333 1.989824e-04 8.421218e-15 FALSE FALSE
ENST00000485050 ENSG00000151576 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT2 protein_coding protein_coding 27.67637 17.39537 38.32592 1.858012 0.4178395 1.139164 10.038914 4.734241 15.1145693 0.1706541 1.676166747 1.672645 0.34617500 0.27946667 0.39376667 0.11430000 2.707469e-01 8.421218e-15 FALSE TRUE
ENST00000493014 ENSG00000151576 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT2 protein_coding protein_coding 27.67637 17.39537 38.32592 1.858012 0.4178395 1.139164 1.468335 1.033078 0.2298582 0.1757205 0.008478167 -2.120594 0.04731667 0.05873333 0.00600000 -0.05273333 8.421218e-15 8.421218e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151576 E001 0.0000000       3 114005833 114006032 200 +      
ENSG00000151576 E002 1.8393607 0.0242605261 6.786430e-01 7.830618e-01 3 114056709 114056734 26 + 0.433 0.427 -0.031
ENSG00000151576 E003 1.8436271 0.1670342710 7.820033e-01 8.600166e-01 3 114056735 114056736 2 + 0.433 0.426 -0.037
ENSG00000151576 E004 1.6921117 0.1593504879 8.940738e-01 9.362679e-01 3 114056737 114056739 3 + 0.401 0.426 0.134
ENSG00000151576 E005 2.2779993 0.0819712815 7.950559e-01 8.690840e-01 3 114056740 114056750 11 + 0.489 0.507 0.088
ENSG00000151576 E006 5.6355079 0.0284043688 2.678700e-01 4.062407e-01 3 114056751 114056756 6 + 0.814 0.736 -0.312
ENSG00000151576 E007 13.9020440 0.0196475684 2.171865e-02 5.509110e-02 3 114056757 114056781 25 + 1.183 1.017 -0.601
ENSG00000151576 E008 27.8950438 0.0027432061 8.419616e-05 4.479027e-04 3 114056782 114056803 22 + 1.475 1.275 -0.696
ENSG00000151576 E009 81.1358457 0.0008468805 2.547502e-06 1.937519e-05 3 114056804 114056864 61 + 1.903 1.802 -0.339
ENSG00000151576 E010 0.8073328 0.0148322326 6.638711e-01 7.718314e-01 3 114056967 114056998 32 + 0.196 0.325 0.971
ENSG00000151576 E011 37.5894085 0.0009025592 1.269423e-03 4.875392e-03 3 114056999 114057021 23 + 1.573 1.477 -0.330
ENSG00000151576 E012 56.9724583 0.0009973402 1.879133e-04 9.119685e-04 3 114057022 114057106 85 + 1.750 1.664 -0.292
ENSG00000151576 E013 2.5777708 0.0068513583 1.195094e-02 3.341456e-02 3 114057107 114057548 442 + 0.606 0.193 -2.444
ENSG00000151576 E014 68.3312866 0.0003679391 2.371141e-06 1.814825e-05 3 114065237 114065243 7 + 1.833 1.719 -0.385
ENSG00000151576 E015 78.8424977 0.0023192014 8.231709e-06 5.576117e-05 3 114065244 114065278 35 + 1.892 1.779 -0.380
ENSG00000151576 E016 81.1025224 0.0003246732 2.264845e-06 1.740783e-05 3 114065279 114065329 51 + 1.901 1.806 -0.319
ENSG00000151576 E017 135.7780714 0.0003301773 1.185626e-04 6.072761e-04 3 114065330 114065457 128 + 2.100 2.084 -0.052
ENSG00000151576 E018 78.5907542 0.0005407423 1.273405e-02 3.528694e-02 3 114066228 114066244 17 + 1.860 1.863 0.012
ENSG00000151576 E019 102.0136047 0.0003612735 2.539764e-04 1.191793e-03 3 114066245 114066283 39 + 1.981 1.953 -0.095
ENSG00000151576 E020 1.9304982 0.0577581243 6.147511e-02 1.291176e-01 3 114066284 114066565 282 + 0.516 0.192 -2.036
ENSG00000151576 E021 125.4903939 0.0011813797 1.287416e-04 6.534243e-04 3 114067987 114068063 77 + 2.070 2.036 -0.114
ENSG00000151576 E022 3.2621959 0.0048008576 2.117776e-03 7.589549e-03 3 114068064 114068324 261 + 0.698 0.192 -2.838
ENSG00000151576 E023 236.0719657 0.0025700582 1.927903e-03 7.001810e-03 3 114070626 114070838 213 + 2.334 2.337 0.013
ENSG00000151576 E024 170.4407695 0.0004996348 1.099526e-02 3.114981e-02 3 114076743 114076838 96 + 2.184 2.220 0.122
ENSG00000151576 E025 150.8056054 0.0002717754 6.665256e-03 2.035189e-02 3 114076839 114076942 104 + 2.132 2.161 0.097
ENSG00000151576 E026 56.2525750 0.0005834456 1.324862e-06 1.071787e-05 3 114076943 114079550 2608 + 1.757 1.609 -0.505
ENSG00000151576 E027 4.3662273 0.0037998819 2.770364e-01 4.165407e-01 3 114079867 114079905 39 + 0.714 0.638 -0.319
ENSG00000151576 E028 193.9026231 0.0022322306 3.017553e-02 7.231248e-02 3 114079906 114080057 152 + 2.239 2.274 0.116
ENSG00000151576 E029 6.0162839 0.0026279872 2.270527e-02 5.714144e-02 3 114082553 114082676 124 + 0.872 0.638 -0.948
ENSG00000151576 E030 153.1084136 0.0002661387 1.062100e-03 4.173822e-03 3 114082677 114082768 92 + 2.144 2.156 0.039
ENSG00000151576 E031 95.7729401 0.0006407994 2.875917e-01 4.280962e-01 3 114082769 114082794 26 + 1.923 1.994 0.238
ENSG00000151576 E032 6.2928971 0.0031118172 1.104201e-01 2.061530e-01 3 114082963 114083003 41 + 0.861 0.737 -0.489
ENSG00000151576 E033 1784.9072717 0.0058405468 6.873687e-11 1.246959e-09 3 114085673 114088422 2750 + 3.125 3.369 0.811