ENSG00000151575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537232 ENSG00000151575 HEK293_OSMI2_2hA HEK293_TMG_2hB TEX9 protein_coding nonsense_mediated_decay 2.273466 0.6249664 4.595009 0.03347851 0.4212855 2.858452 0.09578493 0.01309282 0.1345217 0.01309282 0.13452165 2.645770 0.05702083 0.0227000 0.0263000 0.00360000 0.851353549 0.004782067 FALSE TRUE
ENST00000696102 ENSG00000151575 HEK293_OSMI2_2hA HEK293_TMG_2hB TEX9 protein_coding protein_coding 2.273466 0.6249664 4.595009 0.03347851 0.4212855 2.858452 0.98798238 0.33116986 1.6645076 0.01405200 0.11762796 2.295175 0.52243333 0.5348667 0.3642333 -0.17063333 0.214580218 0.004782067 FALSE TRUE
MSTRG.10869.2 ENSG00000151575 HEK293_OSMI2_2hA HEK293_TMG_2hB TEX9 protein_coding   2.273466 0.6249664 4.595009 0.03347851 0.4212855 2.858452 0.72386555 0.18469575 1.6162140 0.04151232 0.34099234 3.062224 0.24523750 0.2980000 0.3431667 0.04516667 0.826792254 0.004782067 FALSE TRUE
MSTRG.10869.3 ENSG00000151575 HEK293_OSMI2_2hA HEK293_TMG_2hB TEX9 protein_coding   2.273466 0.6249664 4.595009 0.03347851 0.4212855 2.858452 0.16472066 0.00000000 0.5954404 0.00000000 0.04392417 5.919913 0.03875833 0.0000000 0.1313667 0.13136667 0.004782067 0.004782067 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151575 E001 0.4396707 0.0508695835 1.0000000000 1.000000000 15 56243971 56244278 308 + 0.147 0.000 -9.642
ENSG00000151575 E002 0.4460135 0.0619879688 1.0000000000 1.000000000 15 56365426 56365426 1 + 0.147 0.000 -11.484
ENSG00000151575 E003 1.1081736 0.0170561029 0.3382879458 0.482150140 15 56365427 56365437 11 + 0.223 0.411 1.230
ENSG00000151575 E004 2.1475633 0.0072276096 0.9927397258 0.999545926 15 56365438 56365445 8 + 0.417 0.411 -0.033
ENSG00000151575 E005 2.1475633 0.0072276096 0.9927397258 0.999545926 15 56365446 56365446 1 + 0.417 0.411 -0.033
ENSG00000151575 E006 8.0145098 0.0143882236 0.5243707851 0.657901349 15 56365447 56365477 31 + 0.864 0.758 -0.418
ENSG00000151575 E007 2.1206217 0.0242350007 0.9983283886 1.000000000 15 56365478 56365578 101 + 0.417 0.411 -0.036
ENSG00000151575 E008 13.7226666 0.0027987854 0.5215464027 0.655421200 15 56365579 56365670 92 + 1.070 0.985 -0.311
ENSG00000151575 E009 1.2438831 0.1539930488 0.9557694224 0.976252660 15 56365671 56365893 223 + 0.287 0.254 -0.236
ENSG00000151575 E010 0.0000000       15 56373438 56373440 3 +      
ENSG00000151575 E011 13.8927177 0.0158748744 0.5291950541 0.662016240 15 56373441 56373504 64 + 1.075 0.985 -0.328
ENSG00000151575 E012 0.2903454 0.2675498966 1.0000000000   15 56374154 56374623 470 + 0.103 0.000 -10.721
ENSG00000151575 E013 15.0641462 0.0012828116 0.0175582275 0.046172088 15 56383952 56384031 80 + 1.135 0.814 -1.196
ENSG00000151575 E014 2.2176094 0.0064762517 0.0615643170 0.129266233 15 56385232 56385304 73 + 0.479 0.000 -13.277
ENSG00000151575 E015 13.3838147 0.0013064894 0.0066963961 0.020436764 15 56388472 56388520 49 + 1.094 0.694 -1.536
ENSG00000151575 E016 16.9625045 0.0011010139 0.0138968653 0.037993341 15 56389318 56389400 83 + 1.179 0.864 -1.163
ENSG00000151575 E017 19.0519010 0.0013141121 0.2899635670 0.430716554 15 56391243 56391418 176 + 1.202 1.080 -0.435
ENSG00000151575 E018 0.0000000       15 56393654 56394164 511 +      
ENSG00000151575 E019 11.9038318 0.0015536878 0.6953635699 0.795983917 15 56394165 56394247 83 + 1.006 0.948 -0.214
ENSG00000151575 E020 11.9690467 0.0087266981 0.1546067029 0.267884508 15 56394661 56394720 60 + 1.029 0.814 -0.811
ENSG00000151575 E021 13.3902780 0.0022679604 0.9050467940 0.943556668 15 56394721 56394834 114 + 1.045 1.051 0.023
ENSG00000151575 E022 5.1453578 0.0035321354 0.0061222627 0.018928817 15 56394835 56398341 3507 + 0.597 0.985 1.550
ENSG00000151575 E023 13.8722169 0.0013817155 0.7749733710 0.854994088 15 56412302 56412436 135 + 1.055 1.080 0.092
ENSG00000151575 E024 17.2372497 0.0014179719 0.1159273303 0.214132630 15 56427605 56427739 135 + 1.117 1.263 0.519
ENSG00000151575 E025 14.4375281 0.0016333311 0.0640975089 0.133519679 15 56428367 56428473 107 + 1.039 1.224 0.664
ENSG00000151575 E026 43.0960802 0.0006020815 0.0008623726 0.003481745 15 56428474 56430154 1681 + 1.487 1.676 0.646
ENSG00000151575 E027 2.1381095 0.1694878303 0.0247525148 0.061367695 15 56433175 56433249 75 + 0.288 0.760 2.340
ENSG00000151575 E028 0.2966881 0.0290785164 1.0000000000   15 56435781 56435837 57 + 0.103 0.000 -11.017
ENSG00000151575 E029 1.3297351 0.0098836493 0.2004696556 0.326794087 15 56445671 56445997 327 + 0.344 0.000 -12.765