ENSG00000151553

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369246 ENSG00000151553 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2A protein_coding protein_coding 5.145667 2.94838 7.681962 0.5663124 0.6092696 1.378544 0.2229724 0.00000000 0.79316326 0.000000000 0.54549952 6.327621 0.03485417 0.000000000 0.09356667 0.09356667 3.373252e-01 4.260901e-07 FALSE TRUE
ENST00000369248 ENSG00000151553 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2A protein_coding protein_coding 5.145667 2.94838 7.681962 0.5663124 0.6092696 1.378544 3.3812676 1.02163789 5.66823395 0.209196361 0.16185389 2.460506 0.60235000 0.345233333 0.74396667 0.39873333 4.260901e-07 4.260901e-07 FALSE TRUE
ENST00000369250 ENSG00000151553 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2A protein_coding protein_coding 5.145667 2.94838 7.681962 0.5663124 0.6092696 1.378544 0.3191488 0.01980062 0.57720230 0.002875768 0.33334355 4.300444 0.04690417 0.007466667 0.08306667 0.07560000 6.561355e-01 4.260901e-07 FALSE TRUE
ENST00000411414 ENSG00000151553 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2A protein_coding protein_coding 5.145667 2.94838 7.681962 0.5663124 0.6092696 1.378544 0.2849462 1.04197631 0.04983727 0.230944936 0.04983727 -4.135914 0.10040833 0.352833333 0.00750000 -0.34533333 6.255439e-05 4.260901e-07   FALSE
MSTRG.4672.4 ENSG00000151553 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2A protein_coding   5.145667 2.94838 7.681962 0.5663124 0.6092696 1.378544 0.9373322 0.86496565 0.59352534 0.203606290 0.30873104 -0.535812 0.21549167 0.294466667 0.07193333 -0.22253333 2.345804e-01 4.260901e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151553 E001 0.4804688 0.0225547570 5.096855e-01 6.449824e-01 10 114821744 114821769 26 + 0.115 0.230 1.195
ENSG00000151553 E002 3.2723125 0.0064657629 5.340770e-02 1.152163e-01 10 114821770 114821779 10 + 0.622 0.230 -2.197
ENSG00000151553 E003 19.6870828 0.0009783419 3.236723e-04 1.475498e-03 10 114821780 114822123 344 + 1.291 0.901 -1.414
ENSG00000151553 E004 12.0379684 0.0014195130 1.300410e-01 2.342193e-01 10 114830852 114830930 79 + 1.072 0.901 -0.633
ENSG00000151553 E005 26.1917555 0.0009291072 2.252689e-05 1.380224e-04 10 114833233 114833402 170 + 1.411 1.002 -1.454
ENSG00000151553 E006 1.1867525 0.1828613924 2.252325e-01 3.567038e-01 10 114833403 114833465 63 + 0.346 0.001 -8.901
ENSG00000151553 E007 20.8719734 0.0011213883 1.105456e-04 5.704238e-04 10 114835537 114835641 105 + 1.317 0.901 -1.506
ENSG00000151553 E008 20.3879382 0.0013184484 1.773581e-03 6.514902e-03 10 114836124 114836246 123 + 1.295 0.971 -1.162
ENSG00000151553 E009 34.4081267 0.0006004279 3.776275e-04 1.687950e-03 10 114842933 114843226 294 + 1.508 1.231 -0.961
ENSG00000151553 E010 29.5812753 0.0006659466 8.267650e-05 4.406723e-04 10 114843741 114843937 197 + 1.453 1.108 -1.209
ENSG00000151553 E011 22.1149886 0.0008132380 3.091848e-04 1.416888e-03 10 114845367 114845481 115 + 1.336 0.971 -1.308
ENSG00000151553 E012 20.8867978 0.0015183989 9.234554e-04 3.697159e-03 10 114846013 114846089 77 + 1.311 0.971 -1.221
ENSG00000151553 E013 33.2683181 0.0006043654 1.263161e-04 6.426979e-04 10 114846175 114846367 193 + 1.501 1.194 -1.071
ENSG00000151553 E014 32.2835778 0.0006690098 4.891235e-02 1.072240e-01 10 114846559 114846728 170 + 1.464 1.326 -0.479
ENSG00000151553 E015 30.2664850 0.0031484686 1.511274e-02 4.074258e-02 10 114847090 114847233 144 + 1.446 1.248 -0.689
ENSG00000151553 E016 27.9158353 0.0136596243 1.163026e-01 2.146855e-01 10 114848647 114848737 91 + 1.404 1.248 -0.544
ENSG00000151553 E017 26.3595948 0.0007197994 3.910694e-01 5.350091e-01 10 114855197 114855250 54 + 1.366 1.312 -0.188
ENSG00000151553 E018 35.2183713 0.0005950863 2.326497e-01 3.655947e-01 10 114855251 114855340 90 + 1.486 1.416 -0.242
ENSG00000151553 E019 26.9803396 0.0007687958 3.610875e-01 5.054638e-01 10 114860749 114860790 42 + 1.371 1.312 -0.207
ENSG00000151553 E020 38.5571613 0.0005946422 4.338580e-01 5.762478e-01 10 114860791 114860889 99 + 1.518 1.481 -0.127
ENSG00000151553 E021 36.4053382 0.0006015771 4.196074e-02 9.465187e-02 10 114861231 114861334 104 + 1.514 1.380 -0.461
ENSG00000151553 E022 195.6829437 0.0003008097 3.704246e-01 5.148517e-01 10 114861435 114863648 2214 + 2.198 2.241 0.143
ENSG00000151553 E023 110.9781147 0.0003645640 7.968081e-43 3.267379e-40 10 114863649 114864525 877 + 1.820 2.291 1.580
ENSG00000151553 E024 31.4166083 0.0196279380 1.564678e-12 3.711789e-11 10 114864526 114864717 192 + 1.193 1.853 2.269
ENSG00000151553 E025 0.6727692 0.0702716171 1.662570e-01 2.833304e-01 10 114899490 114899832 343 + 0.115 0.379 2.195