ENSG00000151498

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281182 ENSG00000151498 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAD8 protein_coding protein_coding 26.64769 30.23425 19.5188 1.751548 0.9414643 -0.6310577 12.095957 16.628928 8.2949489 0.94819917 0.56108265 -1.00251929 0.44882917 0.55006667 0.42530000 -0.12476667 4.647119e-03 3.98653e-19 FALSE TRUE
ENST00000531338 ENSG00000151498 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAD8 protein_coding retained_intron 26.64769 30.23425 19.5188 1.751548 0.9414643 -0.6310577 1.333796 1.039035 0.9741809 0.03108035 0.08216706 -0.09206756 0.05030417 0.03456667 0.04993333 0.01536667 2.114767e-01 3.98653e-19 TRUE TRUE
ENST00000533387 ENSG00000151498 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAD8 protein_coding retained_intron 26.64769 30.23425 19.5188 1.751548 0.9414643 -0.6310577 2.078486 1.395635 2.0721476 0.07049856 0.25725892 0.56684990 0.07882917 0.04673333 0.10633333 0.05960000 2.694534e-03 3.98653e-19 TRUE FALSE
MSTRG.6599.2 ENSG00000151498 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAD8 protein_coding   26.64769 30.23425 19.5188 1.751548 0.9414643 -0.6310577 1.041392 2.400804 0.0000000 0.18274940 0.00000000 -7.91337085 0.03822083 0.08063333 0.00000000 -0.08063333 3.986530e-19 3.98653e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151498 E001 0.8052696 0.1640243347 3.255572e-01 4.689893e-01 11 134253526 134253530 5 + 0.357 0.176 -1.349
ENSG00000151498 E002 0.8052696 0.1640243347 3.255572e-01 4.689893e-01 11 134253531 134253533 3 + 0.357 0.176 -1.349
ENSG00000151498 E003 1.6168688 0.0679955297 1.668630e-01 2.841092e-01 11 134253534 134253547 14 + 0.550 0.301 -1.352
ENSG00000151498 E004 8.2471662 0.0398155990 3.353138e-01 4.790940e-01 11 134253548 134253557 10 + 1.015 0.891 -0.462
ENSG00000151498 E005 8.3234387 0.0386201752 4.570862e-01 5.974528e-01 11 134253558 134253558 1 + 0.997 0.906 -0.340
ENSG00000151498 E006 8.8404261 0.0221570807 4.322963e-01 5.747578e-01 11 134253559 134253560 2 + 1.015 0.931 -0.313
ENSG00000151498 E007 10.3068222 0.0480848507 6.772599e-01 7.820214e-01 11 134253561 134253563 3 + 1.049 1.006 -0.160
ENSG00000151498 E008 13.1445670 0.0212592349 5.468419e-01 6.769446e-01 11 134253564 134253567 4 + 1.152 1.099 -0.187
ENSG00000151498 E009 13.4745645 0.0169559312 6.284054e-01 7.439432e-01 11 134253568 134253568 1 + 1.152 1.116 -0.129
ENSG00000151498 E010 20.1265483 0.0199340946 2.150834e-01 3.445449e-01 11 134253569 134253576 8 + 1.364 1.257 -0.372
ENSG00000151498 E011 60.2182575 0.0122429489 9.828021e-01 9.933148e-01 11 134253577 134253616 40 + 1.744 1.762 0.061
ENSG00000151498 E012 104.8097347 0.0066693557 4.805939e-01 6.188500e-01 11 134253617 134253709 93 + 2.007 1.989 -0.061
ENSG00000151498 E013 89.3249298 0.0030630571 5.219230e-02 1.130614e-01 11 134256548 134256582 35 + 1.973 1.904 -0.235
ENSG00000151498 E014 82.0298547 0.0062944399 5.492466e-02 1.178698e-01 11 134256583 134256609 27 + 1.949 1.861 -0.296
ENSG00000151498 E015 96.4607024 0.0005921036 6.351908e-03 1.953765e-02 11 134256610 134256648 39 + 2.015 1.932 -0.278
ENSG00000151498 E016 3.4719983 0.0044792665 1.296270e-05 8.386248e-05 11 134256649 134256910 262 + 0.937 0.300 -2.940
ENSG00000151498 E017 168.5351964 0.0011063720 1.672026e-01 2.845646e-01 11 134257088 134257257 170 + 2.218 2.194 -0.080
ENSG00000151498 E018 12.6901706 0.0015082120 7.148934e-05 3.873871e-04 11 134257747 134258514 768 + 1.313 0.965 -1.250
ENSG00000151498 E019 157.9061374 0.0025659268 8.978343e-01 9.387702e-01 11 134258515 134258624 110 + 2.164 2.177 0.042
ENSG00000151498 E020 5.2538836 0.0032311453 4.102069e-04 1.813382e-03 11 134258892 134259007 116 + 1.015 0.573 -1.771
ENSG00000151498 E021 154.6754327 0.0002811128 7.107731e-01 8.078778e-01 11 134259008 134259084 77 + 2.159 2.169 0.032
ENSG00000151498 E022 4.4608320 0.0036895824 8.611346e-03 2.531647e-02 11 134259085 134259237 153 + 0.915 0.573 -1.399
ENSG00000151498 E023 6.4957008 0.0026365485 7.729621e-04 3.161112e-03 11 134259238 134259607 370 + 1.065 0.676 -1.507
ENSG00000151498 E024 199.5515353 0.0002054416 2.816357e-01 4.215556e-01 11 134259608 134259745 138 + 2.244 2.293 0.164
ENSG00000151498 E025 21.4634001 0.0016384664 1.523851e-13 4.219367e-12 11 134259746 134260028 283 + 1.608 1.078 -1.852
ENSG00000151498 E026 19.5741826 0.0009186964 1.659377e-05 1.048264e-04 11 134260029 134260205 177 + 1.470 1.160 -1.082
ENSG00000151498 E027 58.1734847 0.0025963654 2.809384e-12 6.406999e-11 11 134260206 134260925 720 + 1.939 1.601 -1.142
ENSG00000151498 E028 27.3588263 0.0038449606 2.130846e-04 1.020095e-03 11 134260926 134261043 118 + 1.575 1.331 -0.841
ENSG00000151498 E029 218.1506431 0.0004622184 7.188784e-02 1.464780e-01 11 134261044 134261179 136 + 2.270 2.339 0.228
ENSG00000151498 E030 174.6314967 0.0002187944 3.406873e-01 4.846383e-01 11 134261275 134261372 98 + 2.188 2.235 0.159
ENSG00000151498 E031 1.9090881 0.0758902174 3.789749e-01 5.232615e-01 11 134261607 134261737 131 + 0.550 0.396 -0.777
ENSG00000151498 E032 204.7865938 0.0003252160 1.690820e-02 4.473191e-02 11 134261738 134261890 153 + 2.231 2.315 0.281
ENSG00000151498 E033 11.8370912 0.0482223107 4.230351e-02 9.527985e-02 11 134262132 134262184 53 + 1.246 0.975 -0.976
ENSG00000151498 E034 12.7355241 0.0748496289 1.162133e-01 2.145751e-01 11 134262185 134262276 92 + 1.267 1.015 -0.905
ENSG00000151498 E035 18.9718556 0.0011562721 1.633812e-02 4.347264e-02 11 134262277 134262519 243 + 1.379 1.209 -0.595
ENSG00000151498 E036 180.0197890 0.0008807510 4.192130e-04 1.848149e-03 11 134262520 134262622 103 + 2.143 2.273 0.433
ENSG00000151498 E037 11.5640304 0.0015160456 7.540555e-01 8.397865e-01 11 134262623 134262769 147 + 1.081 1.069 -0.045
ENSG00000151498 E038 43.0413480 0.0021719905 2.335237e-01 3.665924e-01 11 134262770 134263120 351 + 1.560 1.653 0.317
ENSG00000151498 E039 30.7244749 0.0121777307 8.693068e-01 9.200063e-01 11 134263121 134263335 215 + 1.475 1.475 0.000
ENSG00000151498 E040 37.4611525 0.0026967780 2.875491e-01 4.280498e-01 11 134263336 134263555 220 + 1.589 1.542 -0.160
ENSG00000151498 E041 31.0944954 0.0050193137 7.423404e-01 8.312449e-01 11 134263556 134264061 506 + 1.482 1.479 -0.010
ENSG00000151498 E042 598.4307056 0.0051648086 9.438462e-06 6.310528e-05 11 134264908 134266000 1093 + 2.632 2.799 0.554