ENSG00000151491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281172 ENSG00000151491 HEK293_OSMI2_2hA HEK293_TMG_2hB EPS8 protein_coding protein_coding 5.187604 1.769975 7.67698 0.06371839 0.2122812 2.11056 0.2174602 0.7443587 0.00000000 0.38466839 0.00000000 -6.237179 0.11567917 0.4124333 0.000000000 -0.41243333 0.0640429594 0.0001135342 FALSE TRUE
ENST00000543468 ENSG00000151491 HEK293_OSMI2_2hA HEK293_TMG_2hB EPS8 protein_coding nonsense_mediated_decay 5.187604 1.769975 7.67698 0.06371839 0.2122812 2.11056 0.1011669 0.3882944 0.00000000 0.19466616 0.00000000 -5.315763 0.05588750 0.2182000 0.000000000 -0.21820000 0.0596979861 0.0001135342 FALSE TRUE
ENST00000644374 ENSG00000151491 HEK293_OSMI2_2hA HEK293_TMG_2hB EPS8 protein_coding protein_coding 5.187604 1.769975 7.67698 0.06371839 0.2122812 2.11056 1.0682523 0.0000000 0.63896074 0.00000000 0.36935031 6.020059 0.23197083 0.0000000 0.084266667 0.08426667 0.4404057535 0.0001135342 FALSE TRUE
ENST00000646918 ENSG00000151491 HEK293_OSMI2_2hA HEK293_TMG_2hB EPS8 protein_coding protein_coding 5.187604 1.769975 7.67698 0.06371839 0.2122812 2.11056 0.1199238 0.2844187 0.05354357 0.09233319 0.02880618 -2.212051 0.05301667 0.1588667 0.006833333 -0.15203333 0.0001135342 0.0001135342 FALSE TRUE
ENST00000647224 ENSG00000151491 HEK293_OSMI2_2hA HEK293_TMG_2hB EPS8 protein_coding protein_coding 5.187604 1.769975 7.67698 0.06371839 0.2122812 2.11056 2.7334020 0.3366670 5.97324120 0.33666696 0.36784815 4.109305 0.38617500 0.2012000 0.777500000 0.57630000 0.0718206537 0.0001135342 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151491 E001 0.0000000       12 15620134 15620157 24 -      
ENSG00000151491 E002 0.3697384 0.0274424043 2.666046e-02 6.528377e-02 12 15620158 15620161 4 - 0.000 0.348 13.525
ENSG00000151491 E003 0.7728880 0.0153787590 1.066730e-03 4.190116e-03 12 15620162 15620180 19 - 0.000 0.539 17.219
ENSG00000151491 E004 1.9906555 0.0081333665 2.433251e-08 2.789713e-07 12 15620181 15620190 10 - 0.000 0.890 18.592
ENSG00000151491 E005 1.9906555 0.0081333665 2.433251e-08 2.789713e-07 12 15620191 15620194 4 - 0.000 0.890 18.592
ENSG00000151491 E006 3.3986351 0.0122805040 1.415589e-09 2.040937e-08 12 15620195 15620233 39 - 0.129 1.059 4.923
ENSG00000151491 E007 16.3898358 0.0011963581 2.322679e-08 2.673946e-07 12 15620234 15620348 115 - 0.998 1.484 1.720
ENSG00000151491 E008 19.3881762 0.0013948321 2.409467e-05 1.467313e-04 12 15620349 15620376 28 - 1.133 1.484 1.230
ENSG00000151491 E009 25.0202568 0.0007965958 1.566877e-06 1.247018e-05 12 15620377 15620411 35 - 1.240 1.592 1.219
ENSG00000151491 E010 88.4422511 0.0003558759 3.848139e-13 1.007349e-11 12 15620412 15620982 571 - 1.798 2.089 0.976
ENSG00000151491 E011 40.9374455 0.0101242950 1.467123e-01 2.572133e-01 12 15620983 15621202 220 - 1.531 1.649 0.405
ENSG00000151491 E012 20.3299752 0.0009906623 4.440260e-01 5.856020e-01 12 15621203 15621273 71 - 1.252 1.328 0.264
ENSG00000151491 E013 39.0534675 0.0006545554 4.765405e-02 1.050039e-01 12 15621274 15621430 157 - 1.505 1.638 0.452
ENSG00000151491 E014 31.6512284 0.0006599213 1.042484e-01 1.969598e-01 12 15623158 15623219 62 - 1.420 1.542 0.417
ENSG00000151491 E015 38.5947847 0.0012115907 3.103584e-01 4.527471e-01 12 15623220 15623287 68 - 1.517 1.592 0.258
ENSG00000151491 E016 51.5354869 0.0005288719 9.784548e-01 9.906499e-01 12 15624227 15624407 181 - 1.658 1.667 0.033
ENSG00000151491 E017 47.2855049 0.0005867104 5.130329e-01 6.478768e-01 12 15631442 15631664 223 - 1.613 1.661 0.166
ENSG00000151491 E018 0.2966881 0.0294072415 8.856431e-01   12 15631665 15631762 98 - 0.129 0.000 -13.657
ENSG00000151491 E019 0.0000000       12 15634739 15634762 24 -      
ENSG00000151491 E020 33.9354011 0.0009364547 6.054865e-01 7.258734e-01 12 15640703 15640846 144 - 1.491 1.466 -0.084
ENSG00000151491 E021 31.3123049 0.0006780581 2.176998e-01 3.476220e-01 12 15641722 15641830 109 - 1.466 1.387 -0.274
ENSG00000151491 E022 17.1621922 0.0010406603 5.177148e-01 6.520508e-01 12 15647127 15647149 23 - 1.213 1.162 -0.181
ENSG00000151491 E023 32.8388383 0.0007038792 2.873267e-02 6.946995e-02 12 15647150 15647260 111 - 1.503 1.352 -0.519
ENSG00000151491 E024 39.4871293 0.0071720487 1.878354e-01 3.110047e-01 12 15650823 15651006 184 - 1.570 1.483 -0.297
ENSG00000151491 E025 28.4538849 0.0007441110 1.199392e-01 2.198922e-01 12 15654145 15654293 149 - 1.437 1.328 -0.378
ENSG00000151491 E026 0.0000000       12 15654294 15654430 137 -      
ENSG00000151491 E027 0.2903454 0.3268663915 1.000000e+00   12 15657894 15658075 182 - 0.128 0.000 -13.470
ENSG00000151491 E028 0.2903454 0.3268663915 1.000000e+00   12 15658076 15658078 3 - 0.128 0.000 -13.470
ENSG00000151491 E029 16.7988085 0.0010291388 5.827964e-01 7.070703e-01 12 15658079 15658153 75 - 1.204 1.162 -0.149
ENSG00000151491 E030 23.1880454 0.0048555467 2.302081e-02 5.779287e-02 12 15658497 15658585 89 - 1.366 1.162 -0.716
ENSG00000151491 E031 29.3714332 0.0027729651 6.448908e-03 1.979049e-02 12 15660614 15660740 127 - 1.464 1.246 -0.757
ENSG00000151491 E032 24.1768201 0.0007718114 7.315332e-03 2.203813e-02 12 15662026 15662099 74 - 1.388 1.162 -0.793
ENSG00000151491 E033 0.0000000       12 15662100 15662115 16 -      
ENSG00000151491 E034 0.6674587 0.0212536040 9.006883e-01 9.406537e-01 12 15662193 15662335 143 - 0.181 0.208 0.252
ENSG00000151491 E035 1.0287806 0.0118818782 1.221591e-01 2.230211e-01 12 15662336 15662692 357 - 0.344 0.000 -15.315
ENSG00000151491 E036 0.7362571 0.0352605321 3.917178e-01 5.356432e-01 12 15665023 15665106 84 - 0.181 0.347 1.244
ENSG00000151491 E037 0.4355181 0.6637585809 8.769498e-01 9.250036e-01 12 15665349 15665755 407 - 0.180 0.000 -13.796
ENSG00000151491 E038 29.2351637 0.0006848548 8.160889e-05 4.356192e-04 12 15665756 15665892 137 - 1.484 1.162 -1.124
ENSG00000151491 E039 28.1768450 0.0007026077 5.408875e-04 2.312977e-03 12 15666440 15666522 83 - 1.461 1.180 -0.981
ENSG00000151491 E040 27.2732018 0.0007529740 8.307389e-03 2.456315e-02 12 15669387 15669465 79 - 1.437 1.230 -0.722
ENSG00000151491 E041 23.3013053 0.0021841730 2.615024e-02 6.425032e-02 12 15669466 15669518 53 - 1.369 1.180 -0.664
ENSG00000151491 E042 16.3698617 0.0011391994 3.822507e-01 5.264798e-01 12 15669519 15669536 18 - 1.199 1.124 -0.269
ENSG00000151491 E043 14.1395418 0.0012457167 5.531861e-01 6.823752e-01 12 15669664 15669667 4 - 1.133 1.082 -0.185
ENSG00000151491 E044 33.6692692 0.0025271109 1.638351e-03 6.084345e-03 12 15669668 15669825 158 - 1.528 1.289 -0.827
ENSG00000151491 E045 10.6114476 0.0016016310 4.365281e-02 9.774685e-02 12 15670856 15670858 3 - 1.061 0.815 -0.926
ENSG00000151491 E046 21.4911900 0.0013370133 1.505448e-02 4.061210e-02 12 15670859 15670923 65 - 1.339 1.124 -0.762
ENSG00000151491 E047 0.0000000       12 15672454 15672504 51 -      
ENSG00000151491 E048 25.9934700 0.0007895689 3.267571e-04 1.487770e-03 12 15681226 15681302 77 - 1.432 1.124 -1.081
ENSG00000151491 E049 26.0395692 0.0008013634 1.814754e-05 1.136904e-04 12 15682893 15682972 80 - 1.443 1.059 -1.354
ENSG00000151491 E050 0.1472490 0.0426454376 1.000000e+00   12 15682973 15684168 1196 - 0.069 0.000 -12.697
ENSG00000151491 E051 0.0000000       12 15684169 15684196 28 -      
ENSG00000151491 E052 0.1515154 0.0423510760 1.000000e+00   12 15684197 15684302 106 - 0.069 0.000 -12.697
ENSG00000151491 E053 0.0000000       12 15712853 15713265 413 -      
ENSG00000151491 E054 1.1972479 0.0784662858 1.070801e-01 2.012241e-01 12 15713266 15713325 60 - 0.377 0.000 -15.494
ENSG00000151491 E055 0.0000000       12 15728129 15728265 137 -      
ENSG00000151491 E056 0.1451727 0.0427806776 1.000000e+00   12 15780579 15780727 149 - 0.069 0.000 -12.696
ENSG00000151491 E057 0.0000000       12 15787963 15788010 48 -      
ENSG00000151491 E058 23.4976962 0.0007843132 6.487374e-04 2.711528e-03 12 15789161 15789386 226 - 1.388 1.082 -1.082
ENSG00000151491 E059 1.2607212 0.2229598417 6.125440e-01 7.314556e-01 12 15789387 15789418 32 - 0.344 0.211 -0.952
ENSG00000151491 E060 0.0000000       12 15813493 15813561 69 -      
ENSG00000151491 E061 0.1472490 0.0426454376 1.000000e+00   12 15813562 15813752 191 - 0.069 0.000 -12.697
ENSG00000151491 E062 0.1472490 0.0426454376 1.000000e+00   12 15817048 15817110 63 - 0.069 0.000 -12.697
ENSG00000151491 E063 0.0000000       12 15818053 15818063 11 -      
ENSG00000151491 E064 0.4407149 0.0229110659 6.484525e-01 7.599615e-01 12 15828181 15828372 192 - 0.129 0.208 0.833
ENSG00000151491 E065 0.6590396 0.0228341171 9.007010e-01 9.406617e-01 12 15837573 15837724 152 - 0.181 0.208 0.253
ENSG00000151491 E066 1.8099978 0.0087003103 4.700653e-04 2.045584e-03 12 15881107 15881199 93 - 0.181 0.772 3.248
ENSG00000151491 E067 4.7573235 0.0316058193 3.654450e-09 4.879649e-08 12 15881780 15882262 483 - 0.270 1.178 4.029
ENSG00000151491 E068 1.4748035 0.0875966816 5.504657e-02 1.180766e-01 12 15882263 15882329 67 - 0.228 0.609 2.155