ENSG00000151474

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357447 ENSG00000151474 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD4A protein_coding protein_coding 2.569275 3.662739 2.818881 0.7321674 0.7954191 -0.3766251 0.6304250 0.74049008 0.7994384 0.05715153 0.08972719 0.1090883 0.26478333 0.21320000 0.3080333 0.09483333 4.533747e-01 1.010483e-06 FALSE TRUE
ENST00000475325 ENSG00000151474 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD4A protein_coding retained_intron 2.569275 3.662739 2.818881 0.7321674 0.7954191 -0.3766251 0.5215363 1.05352506 0.0000000 0.23358762 0.00000000 -6.7327102 0.19693750 0.31563333 0.0000000 -0.31563333 1.010483e-06 1.010483e-06   FALSE
ENST00000632570 ENSG00000151474 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD4A protein_coding protein_coding 2.569275 3.662739 2.818881 0.7321674 0.7954191 -0.3766251 0.1536439 0.06339287 0.1258484 0.06339287 0.12584838 0.8882855 0.06709583 0.02483333 0.0651000 0.04026667 9.993984e-01 1.010483e-06 TRUE TRUE
ENST00000649099 ENSG00000151474 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD4A protein_coding protein_coding 2.569275 3.662739 2.818881 0.7321674 0.7954191 -0.3766251 0.3597215 0.86552400 0.6925200 0.86552400 0.69251999 -0.3176074 0.09240000 0.17160000 0.1571667 -0.01443333 9.960290e-01 1.010483e-06   FALSE
MSTRG.3573.3 ENSG00000151474 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD4A protein_coding   2.569275 3.662739 2.818881 0.7321674 0.7954191 -0.3766251 0.2871624 0.22134297 0.2410423 0.22134297 0.24104232 0.1178973 0.12510000 0.08676667 0.1138667 0.02710000 1.000000e+00 1.010483e-06 FALSE TRUE
MSTRG.3573.5 ENSG00000151474 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMD4A protein_coding   2.569275 3.662739 2.818881 0.7321674 0.7954191 -0.3766251 0.3021663 0.24195792 0.5617856 0.12993183 0.16960300 1.1822914 0.13330833 0.05700000 0.2292000 0.17220000 2.866333e-01 1.010483e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151474 E001 73.8243578 0.0287961629 7.228500e-01 0.8168653978 10 13643706 13646271 2566 - 1.852 1.887 0.116
ENSG00000151474 E002 11.7635367 0.0101433476 1.905528e-05 0.0001187723 10 13646272 13646326 55 - 0.775 1.262 1.802
ENSG00000151474 E003 5.9711535 0.0028777088 6.887420e-04 0.0028579587 10 13646327 13646333 7 - 0.520 0.985 1.905
ENSG00000151474 E004 5.6713449 0.0029570287 4.224087e-04 0.0018600729 10 13646334 13646334 1 - 0.474 0.970 2.074
ENSG00000151474 E005 46.1028203 0.0006351111 2.163718e-05 0.0001330660 10 13646335 13647035 701 - 1.536 1.757 0.750
ENSG00000151474 E006 0.0000000       10 13651903 13651974 72 -      
ENSG00000151474 E007 11.5140416 0.0302249134 9.467433e-02 0.1823963938 10 13654416 13654512 97 - 0.950 1.168 0.792
ENSG00000151474 E008 0.3697384 0.0274424043 2.114682e-01 0.3402262854 10 13654513 13654526 14 - 0.000 0.215 12.342
ENSG00000151474 E009 20.2706427 0.0012998866 7.470088e-01 0.8346359677 10 13656636 13657261 626 - 1.332 1.313 -0.065
ENSG00000151474 E010 16.3657126 0.0013862186 2.250808e-01 0.3565230992 10 13657262 13657522 261 - 1.282 1.188 -0.332
ENSG00000151474 E011 14.5577144 0.0012904214 3.449438e-01 0.4890367200 10 13659323 13659490 168 - 1.227 1.151 -0.270
ENSG00000151474 E012 17.8438157 0.0011425053 3.704216e-01 0.5148512280 10 13660316 13660553 238 - 1.304 1.239 -0.228
ENSG00000151474 E013 6.2028222 0.0095757416 7.189910e-01 0.8139659155 10 13663453 13663509 57 - 0.820 0.871 0.196
ENSG00000151474 E014 9.8671460 0.0022258608 3.535593e-01 0.4978130195 10 13666097 13666223 127 - 1.076 0.985 -0.331
ENSG00000151474 E015 8.0317385 0.0021280664 6.640513e-01 0.7719533293 10 13666224 13666325 102 - 0.982 0.939 -0.159
ENSG00000151474 E016 9.2388740 0.0990499172 6.279109e-01 0.7435809205 10 13670406 13670528 123 - 1.063 0.957 -0.390
ENSG00000151474 E017 12.4215544 0.0284592116 5.109147e-01 0.6460589244 10 13674911 13675037 127 - 1.162 1.089 -0.265
ENSG00000151474 E018 5.8261538 0.0029757629 3.366550e-02 0.0790881615 10 13675038 13675044 7 - 0.951 0.686 -1.042
ENSG00000151474 E019 0.4428904 0.3940384437 3.038648e-01 0.4458526949 10 13684036 13684864 829 - 0.000 0.223 11.347
ENSG00000151474 E020 0.0000000       10 13692169 13693481 1313 -      
ENSG00000151474 E021 1.5092468 0.0093132706 6.949280e-01 0.7956391163 10 13693482 13693517 36 - 0.423 0.359 -0.363
ENSG00000151474 E022 0.1515154 0.0422214632 4.692704e-01   10 13693518 13693702 185 - 0.124 0.000 -12.214
ENSG00000151474 E023 0.0000000       10 13693703 13693897 195 -      
ENSG00000151474 E024 10.1659689 0.0150659508 7.244350e-01 0.8179489229 10 13693898 13693982 85 - 1.051 1.016 -0.125
ENSG00000151474 E025 10.1452421 0.0452304096 9.352870e-01 0.9632519677 10 13693983 13694039 57 - 1.024 1.045 0.078
ENSG00000151474 E026 14.9463897 0.0013118552 6.700206e-01 0.7766122446 10 13701340 13701478 139 - 1.172 1.215 0.150
ENSG00000151474 E027 10.1042703 0.0017783538 5.835509e-01 0.7076504005 10 13707037 13707113 77 - 1.063 1.013 -0.184
ENSG00000151474 E028 2.3250369 0.0924365066 7.079463e-01 0.8057040902 10 13707114 13707275 162 - 0.475 0.552 0.371
ENSG00000151474 E029 1.6231109 0.5856707743 5.391532e-01 0.6704318564 10 13707276 13707345 70 - 0.476 0.362 -0.616
ENSG00000151474 E030 3.5730595 0.0044033582 3.446408e-01 0.4887246154 10 13707346 13707757 412 - 0.724 0.590 -0.573
ENSG00000151474 E031 9.4306645 0.0018386248 1.493537e-03 0.0056152354 10 13737844 13737930 87 - 1.163 0.831 -1.230
ENSG00000151474 E032 8.1592204 0.0062306815 1.438868e-02 0.0391066751 10 13740194 13740251 58 - 1.087 0.810 -1.040
ENSG00000151474 E033 8.5792227 0.0021883582 9.145537e-03 0.0266458724 10 13740512 13740577 66 - 1.110 0.831 -1.042
ENSG00000151474 E034 8.8444585 0.0020391403 1.717735e-01 0.2905195672 10 13747736 13747819 84 - 1.063 0.923 -0.519
ENSG00000151474 E035 0.7353267 0.0188451322 1.582259e-01 0.2727516242 10 13753056 13753100 45 - 0.366 0.121 -2.044
ENSG00000151474 E036 0.0000000       10 13759165 13759506 342 -      
ENSG00000151474 E037 6.5820027 0.0030713933 2.236104e-01 0.3547101150 10 13761647 13761669 23 - 0.951 0.810 -0.540
ENSG00000151474 E038 7.8323423 0.0069000013 5.455581e-02 0.1172110292 10 13762624 13762680 57 - 1.051 0.831 -0.826
ENSG00000151474 E039 5.2544472 0.0296401124 3.934563e-01 0.5373544608 10 13782922 13782928 7 - 0.861 0.739 -0.485
ENSG00000151474 E040 6.9182307 0.0267535541 2.418969e-01 0.3764273437 10 13782929 13783006 78 - 0.981 0.829 -0.580
ENSG00000151474 E041 12.0959988 0.0025819237 8.694202e-01 0.9200598746 10 13796496 13796588 93 - 1.099 1.120 0.077
ENSG00000151474 E042 10.7150850 0.0134344263 6.034168e-01 0.7242125740 10 13810814 13810908 95 - 1.025 1.089 0.234
ENSG00000151474 E043 7.1716262 0.0088468446 7.614544e-01 0.8453236757 10 13858847 13858912 66 - 0.881 0.923 0.160
ENSG00000151474 E044 0.0000000       10 13866261 13866304 44 -      
ENSG00000151474 E045 0.2998086 0.0297424351 9.734377e-01   10 13890479 13890658 180 - 0.124 0.121 -0.046
ENSG00000151474 E046 4.5728301 0.0071003354 6.450230e-01 0.7572374271 10 13891624 13891756 133 - 0.696 0.765 0.281
ENSG00000151474 E047 0.3299976 0.0278317593 2.116785e-01   10 13892245 13892296 52 - 0.000 0.215 12.338
ENSG00000151474 E048 0.0000000       10 13971656 13972369 714 -      
ENSG00000151474 E049 0.2966881 0.0290785164 1.891372e-01   10 14008060 14008533 474 - 0.220 0.000 -13.223
ENSG00000151474 E050 0.0000000       10 14024354 14024375 22 -      
ENSG00000151474 E051 0.0000000       10 14024376 14024547 172 -      
ENSG00000151474 E052 0.0000000       10 14082947 14083813 867 -      
ENSG00000151474 E053 0.0000000       10 14097010 14097138 129 -      
ENSG00000151474 E054 0.5932745 0.0256694180 9.629109e-01 0.9805548258 10 14174012 14174366 355 - 0.220 0.215 -0.047
ENSG00000151474 E055 0.0000000       10 14326175 14326983 809 -      
ENSG00000151474 E056 0.0000000       10 14330058 14330183 126 -      
ENSG00000151474 E057 0.0000000       10 14330597 14330924 328 -      
ENSG00000151474 E058 0.0000000       10 14388681 14388903 223 -      
ENSG00000151474 E059 0.0000000       10 14462068 14462142 75 -