ENSG00000151466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281142 ENSG00000151466 HEK293_OSMI2_2hA HEK293_TMG_2hB SCLT1 protein_coding protein_coding 8.006775 5.210791 9.902745 0.4090424 0.2680898 0.9250164 4.5916207 1.843783 6.0273549 0.2682107 0.17483528 1.703444220 0.54687500 0.3616333 0.60856667 0.2469333 1.755977e-02 2.24802e-07 FALSE TRUE
ENST00000503401 ENSG00000151466 HEK293_OSMI2_2hA HEK293_TMG_2hB SCLT1 protein_coding protein_coding 8.006775 5.210791 9.902745 0.4090424 0.2680898 0.9250164 0.4435068 0.000000 0.5867609 0.0000000 0.03062902 5.899081199 0.04986667 0.0000000 0.05950000 0.0595000 2.248020e-07 2.24802e-07 TRUE FALSE
ENST00000506368 ENSG00000151466 HEK293_OSMI2_2hA HEK293_TMG_2hB SCLT1 protein_coding protein_coding 8.006775 5.210791 9.902745 0.4090424 0.2680898 0.9250164 1.0118633 1.346222 0.9710571 0.1066636 0.11292502 -0.467184842 0.14921250 0.2592333 0.09873333 -0.1605000 9.457515e-05 2.24802e-07 FALSE TRUE
ENST00000511426 ENSG00000151466 HEK293_OSMI2_2hA HEK293_TMG_2hB SCLT1 protein_coding protein_coding 8.006775 5.210791 9.902745 0.4090424 0.2680898 0.9250164 1.5145722 1.772757 1.7740305 0.5298646 0.24094654 0.001030175 0.19429583 0.3315333 0.17816667 -0.1533667 1.893640e-01 2.24802e-07 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151466 E001 0.0000000       4 128864824 128864920 97 -      
ENSG00000151466 E002 0.0000000       4 128864921 128864991 71 -      
ENSG00000151466 E003 0.0000000       4 128864992 128864992 1 -      
ENSG00000151466 E004 0.9222279 0.0134063364 4.095011e-01 5.531147e-01 4 128870849 128870907 59 - 0.226 0.380 1.035
ENSG00000151466 E005 7.1557094 0.0053244951 1.384196e-01 2.458923e-01 4 128870908 128871543 636 - 0.825 1.013 0.713
ENSG00000151466 E006 3.3404430 0.0298035358 1.357044e-01 2.420859e-01 4 128871544 128872204 661 - 0.707 0.456 -1.139
ENSG00000151466 E007 1.6325385 0.4531370158 7.281380e-02 1.480208e-01 4 128872205 128872322 118 - 0.545 0.000 -12.036
ENSG00000151466 E008 3.5836435 0.0325695478 8.957760e-01 9.374176e-01 4 128872323 128873105 783 - 0.644 0.632 -0.055
ENSG00000151466 E009 1.0631342 0.0134078484 6.083545e-01 7.281122e-01 4 128873106 128873243 138 - 0.281 0.380 0.620
ENSG00000151466 E010 0.9986021 0.0122080561 9.995225e-01 1.000000e+00 4 128873244 128874414 1171 - 0.281 0.286 0.038
ENSG00000151466 E011 0.8448967 0.3265639691 6.891089e-01 7.910501e-01 4 128874415 128874466 52 - 0.226 0.291 0.487
ENSG00000151466 E012 1.2596890 0.0104257409 6.091031e-01 7.286552e-01 4 128874467 128875208 742 - 0.374 0.286 -0.548
ENSG00000151466 E013 1.0791411 0.4259032446 4.524154e-01 5.932678e-01 4 128876507 128876636 130 - 0.227 0.392 1.096
ENSG00000151466 E014 0.0000000       4 128883993 128883996 4 -      
ENSG00000151466 E015 18.0620060 0.0010692871 1.075040e-01 2.018565e-01 4 128883997 128884345 349 - 1.210 1.351 0.494
ENSG00000151466 E016 12.4970695 0.0017520121 5.961911e-01 7.181655e-01 4 128884346 128884389 44 - 1.100 1.162 0.221
ENSG00000151466 E017 22.9577805 0.0008190575 4.940421e-01 6.310499e-01 4 128884390 128884539 150 - 1.340 1.402 0.214
ENSG00000151466 E018 30.9920783 0.0177821436 9.212870e-01 9.543171e-01 4 128888679 128888774 96 - 1.475 1.500 0.085
ENSG00000151466 E019 28.0511351 0.0163423115 3.638024e-01 5.082388e-01 4 128891059 128891137 79 - 1.469 1.397 -0.247
ENSG00000151466 E020 47.4416601 0.0008338604 8.170252e-02 1.622242e-01 4 128936655 128936851 197 - 1.696 1.614 -0.278
ENSG00000151466 E021 43.8247782 0.0226993038 8.196387e-02 1.626289e-01 4 128942996 128943188 193 - 1.679 1.540 -0.473
ENSG00000151466 E022 41.7899246 0.0048177070 1.704091e-02 4.502578e-02 4 128946007 128946152 146 - 1.662 1.516 -0.500
ENSG00000151466 E023 31.0904659 0.0110893290 2.426244e-03 8.540883e-03 4 128948496 128948570 75 - 1.566 1.315 -0.866
ENSG00000151466 E024 0.4375944 0.0247167649 2.565060e-01 3.934697e-01 4 128952343 128952532 190 - 0.226 0.000 -10.158
ENSG00000151466 E025 27.5317477 0.0008613525 1.815670e-03 6.649397e-03 4 128952769 128952840 72 - 1.507 1.293 -0.739
ENSG00000151466 E026 32.0658691 0.0008486409 3.485734e-02 8.137547e-02 4 128957026 128957124 99 - 1.545 1.418 -0.437
ENSG00000151466 E027 38.0744699 0.0089269690 4.052591e-01 5.489427e-01 4 128959600 128959777 178 - 1.593 1.541 -0.179
ENSG00000151466 E028 26.3573645 0.0010348079 7.634264e-02 1.536515e-01 4 128965227 128965318 92 - 1.458 1.342 -0.401
ENSG00000151466 E029 32.7194068 0.0006096720 5.971242e-05 3.300175e-04 4 128970378 128970468 91 - 1.590 1.333 -0.887
ENSG00000151466 E030 0.0000000       4 128970469 128972372 1904 -      
ENSG00000151466 E031 27.3812079 0.0007364464 6.311335e-05 3.467206e-04 4 128992167 128992237 71 - 1.522 1.238 -0.984
ENSG00000151466 E032 0.0000000       4 128997204 128997285 82 -      
ENSG00000151466 E033 21.9967960 0.0008983161 6.813087e-04 2.830648e-03 4 128997874 128997939 66 - 1.426 1.162 -0.925
ENSG00000151466 E034 27.2134282 0.0020387516 3.899238e-03 1.286103e-02 4 128999672 128999794 123 - 1.498 1.294 -0.706
ENSG00000151466 E035 27.5929114 0.0016258034 4.504695e-05 2.566002e-04 4 129003741 129003876 136 - 1.525 1.227 -1.034
ENSG00000151466 E036 47.9750696 0.0029792171 1.247861e-20 8.599621e-19 4 129036595 129038126 1532 - 1.396 1.929 1.815
ENSG00000151466 E037 33.3217625 0.0008835307 8.590774e-01 9.130671e-01 4 129039041 129039096 56 - 1.510 1.533 0.078
ENSG00000151466 E038 0.0000000       4 129039193 129039229 37 -      
ENSG00000151466 E039 55.2308305 0.0602694740 4.736317e-02 1.044747e-01 4 129039230 129040212 983 - 1.603 1.901 1.011
ENSG00000151466 E040 50.4371461 0.0007405561 3.105622e-03 1.057690e-02 4 129043395 129043467 73 - 1.634 1.793 0.538
ENSG00000151466 E041 50.6280957 0.0007060379 2.322246e-03 8.220153e-03 4 129043993 129044051 59 - 1.634 1.796 0.549
ENSG00000151466 E042 2.1317824 0.0126694871 3.380366e-01 4.819098e-01 4 129076595 129076660 66 - 0.544 0.380 -0.838
ENSG00000151466 E043 52.8252356 0.0004641216 2.856601e-01 4.260154e-01 4 129082306 129082373 68 - 1.692 1.755 0.216
ENSG00000151466 E044 48.6937267 0.0008203284 4.285236e-03 1.394122e-02 4 129093070 129093142 73 - 1.620 1.776 0.530
ENSG00000151466 E045 94.7795038 0.0021155986 4.813547e-01 6.195896e-01 4 129093143 129093600 458 - 1.952 1.993 0.136