ENSG00000151422

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502752 ENSG00000151422 HEK293_OSMI2_2hA HEK293_TMG_2hB FER protein_coding processed_transcript 1.95314 0.3360409 3.838791 0.06329951 0.2610034 3.475391 0.04235373 0.02487649 0.06371211 0.02487649 0.02826775 1.0796468 0.03196667 0.07476667 0.01706667 -0.0577000 0.4511749563 0.0004389034 FALSE TRUE
ENST00000505323 ENSG00000151422 HEK293_OSMI2_2hA HEK293_TMG_2hB FER protein_coding processed_transcript 1.95314 0.3360409 3.838791 0.06329951 0.2610034 3.475391 0.47119934 0.00000000 1.32823614 0.00000000 0.22958771 7.0641889 0.13190000 0.00000000 0.34230000 0.3423000 0.0004389034 0.0004389034 FALSE TRUE
ENST00000513676 ENSG00000151422 HEK293_OSMI2_2hA HEK293_TMG_2hB FER protein_coding processed_transcript 1.95314 0.3360409 3.838791 0.06329951 0.2610034 3.475391 0.06381504 0.05274777 0.07336410 0.05274777 0.03674789 0.4098621 0.04259167 0.11793333 0.01853333 -0.0994000 0.6042899258 0.0004389034 FALSE FALSE
ENST00000618353 ENSG00000151422 HEK293_OSMI2_2hA HEK293_TMG_2hB FER protein_coding protein_coding 1.95314 0.3360409 3.838791 0.06329951 0.2610034 3.475391 0.18905392 0.13711736 0.51841381 0.07493206 0.13548876 1.8447006 0.25992917 0.37280000 0.13943333 -0.2333667 0.5080969275 0.0004389034 FALSE TRUE
MSTRG.26704.4 ENSG00000151422 HEK293_OSMI2_2hA HEK293_TMG_2hB FER protein_coding   1.95314 0.3360409 3.838791 0.06329951 0.2610034 3.475391 0.69303679 0.04525938 1.26307171 0.04525938 0.10542813 4.5259504 0.26529167 0.10116667 0.33273333 0.2315667 0.2167745509 0.0004389034 FALSE TRUE
MSTRG.26704.5 ENSG00000151422 HEK293_OSMI2_2hA HEK293_TMG_2hB FER protein_coding   1.95314 0.3360409 3.838791 0.06329951 0.2610034 3.475391 0.40364183 0.07603987 0.45604905 0.07603987 0.08659776 2.4374045 0.20110833 0.33333333 0.11730000 -0.2160333 0.9053834760 0.0004389034 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151422 E001 0.0000000       5 108747841 108747896 56 +      
ENSG00000151422 E002 0.4418608 0.026550448 1.00000000 1.00000000 5 108747897 108748000 104 + 0.130 0.000 -9.020
ENSG00000151422 E003 0.5181333 0.020400220 0.27343934 0.41247452 5 108748399 108748633 235 + 0.091 0.282 1.973
ENSG00000151422 E004 0.2966881 0.029078516 1.00000000   5 108748939 108748951 13 + 0.091 0.000 -10.288
ENSG00000151422 E005 0.2966881 0.029078516 1.00000000   5 108748952 108748961 10 + 0.091 0.000 -10.288
ENSG00000151422 E006 0.8984834 0.016948763 0.56688966 0.69376967 5 108748962 108748966 5 + 0.230 0.000 -11.711
ENSG00000151422 E007 3.6310039 0.004383900 0.63593693 0.75008463 5 108748967 108748993 27 + 0.551 0.451 -0.489
ENSG00000151422 E008 5.1164070 0.003300359 0.27963968 0.41939975 5 108768093 108768238 146 + 0.674 0.451 -1.030
ENSG00000151422 E009 0.5964967 0.020049642 0.41732888 0.56070143 5 108782663 108782755 93 + 0.130 0.281 1.383
ENSG00000151422 E010 11.1147955 0.001656656 0.61128823 0.73041136 5 108798124 108798389 266 + 0.944 0.868 -0.288
ENSG00000151422 E011 7.7837020 0.002189158 0.38918007 0.53329039 5 108832770 108832943 174 + 0.818 0.667 -0.615
ENSG00000151422 E012 5.6144680 0.002928885 0.21512092 0.34457310 5 108835708 108835807 100 + 0.705 0.451 -1.158
ENSG00000151422 E013 0.0000000       5 108841831 108841868 38 +      
ENSG00000151422 E014 0.0000000       5 108842262 108843001 740 +      
ENSG00000151422 E015 6.3850548 0.006778109 0.37466789 0.51908412 5 108867767 108867950 184 + 0.743 0.572 -0.728
ENSG00000151422 E016 6.8331445 0.027421035 0.33444419 0.47819173 5 108871365 108871502 138 + 0.769 0.573 -0.830
ENSG00000151422 E017 8.2621963 0.002184707 0.13386991 0.23953053 5 108872093 108872212 120 + 0.848 0.572 -1.145
ENSG00000151422 E018 7.5666355 0.002323716 0.44445110 0.58602400 5 108883396 108883518 123 + 0.803 0.667 -0.553
ENSG00000151422 E019 0.0000000       5 108897648 108897658 11 +      
ENSG00000151422 E020 9.0468287 0.002020343 0.08795395 0.17200827 5 108897659 108897848 190 + 0.882 0.572 -1.277
ENSG00000151422 E021 0.4407149 0.023094687 0.27506376 0.41432118 5 108924606 108924607 2 + 0.091 0.281 1.969
ENSG00000151422 E022 5.3865638 0.003295665 0.97650750 0.98932268 5 108924608 108924789 182 + 0.663 0.667 0.017
ENSG00000151422 E023 12.4249217 0.001443345 0.68441441 0.78739931 5 108946130 108946222 93 + 0.977 0.919 -0.219
ENSG00000151422 E024 18.1276688 0.001198345 0.44788720 0.58924636 5 108954729 108954932 204 + 1.136 1.042 -0.338
ENSG00000151422 E025 15.2594785 0.001229847 0.87323039 0.92257112 5 108959225 108959347 123 + 1.064 1.042 -0.078
ENSG00000151422 E026 9.0980455 0.001938389 0.62056184 0.73770011 5 109037422 109037478 57 + 0.848 0.918 0.270
ENSG00000151422 E027 12.5828300 0.001655747 0.35124579 0.49545780 5 109044680 109044795 116 + 0.961 1.077 0.426
ENSG00000151422 E028 0.0000000       5 109044796 109044826 31 +      
ENSG00000151422 E029 8.9097804 0.001858921 0.03873377 0.08868751 5 109047104 109047198 95 + 0.803 1.077 1.032
ENSG00000151422 E030 13.2944311 0.001386379 0.02422777 0.06028052 5 109100396 109100519 124 + 0.961 1.217 0.928
ENSG00000151422 E031 0.0000000       5 109177517 109177629 113 +      
ENSG00000151422 E032 17.1190056 0.015575109 0.11299579 0.20991376 5 109180747 109180901 155 + 1.076 1.261 0.658
ENSG00000151422 E033 14.3847250 0.001782048 0.18431981 0.30664987 5 109186200 109186322 123 + 1.013 1.166 0.555
ENSG00000151422 E034 272.1642147 0.002405464 0.74994497 0.83675806 5 109187433 109196841 9409 + 2.271 2.261 -0.032