ENSG00000151414

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367385 ENSG00000151414 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK7 protein_coding protein_coding 8.347343 1.865962 15.01652 0.409201 0.3181661 3.001808 5.8485707 0.0814612 12.02942738 0.04084757 0.40443973 7.0403911 0.59325000 0.05616667 0.80190000 0.74573333 7.790912e-07 7.790912e-07 FALSE TRUE
ENST00000493790 ENSG00000151414 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK7 protein_coding retained_intron 8.347343 1.865962 15.01652 0.409201 0.3181661 3.001808 0.1789378 0.5964704 0.06471016 0.59647035 0.06471016 -3.0210608 0.09185833 0.22723333 0.00450000 -0.22273333 6.822315e-01 7.790912e-07 FALSE FALSE
ENST00000538004 ENSG00000151414 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK7 protein_coding protein_coding 8.347343 1.865962 15.01652 0.409201 0.3181661 3.001808 1.4610527 1.1880306 0.98249829 0.23138128 0.49503141 -0.2715283 0.25646667 0.71660000 0.06406667 -0.65253333 5.766320e-02 7.790912e-07 FALSE TRUE
MSTRG.2800.8 ENSG00000151414 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK7 protein_coding   8.347343 1.865962 15.01652 0.409201 0.3181661 3.001808 0.7079593 0.0000000 1.36401268 0.00000000 0.69308481 7.1022515 0.04662500 0.00000000 0.09193333 0.09193333 4.789949e-01 7.790912e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151414 E001 0.2987644 0.0276275399 1.000000e+00   1 198156994 198156997 4 + 0.061 0.000 -9.209
ENSG00000151414 E002 10.1441223 0.0430926445 1.107913e-02 3.135700e-02 1 198156998 198157096 99 + 0.783 0.381 -1.848
ENSG00000151414 E003 10.1355895 0.0426343782 1.091641e-02 3.096069e-02 1 198157097 198157120 24 + 0.782 0.381 -1.847
ENSG00000151414 E004 31.2019062 0.0017494064 4.527525e-07 4.038821e-06 1 198157121 198157276 156 + 1.220 0.717 -1.887
ENSG00000151414 E005 0.0000000       1 198206874 198207224 351 +      
ENSG00000151414 E006 0.0000000       1 198208538 198208588 51 +      
ENSG00000151414 E007 0.2924217 0.0276762307 1.000000e+00   1 198209736 198209779 44 + 0.061 0.000 -9.206
ENSG00000151414 E008 0.0000000       1 198220799 198220998 200 +      
ENSG00000151414 E009 3.2484663 0.0048059286 6.574462e-02 1.362806e-01 1 198220999 198221110 112 + 0.425 0.000 -12.665
ENSG00000151414 E010 45.0223051 0.0037887923 7.830901e-08 8.116981e-07 1 198232553 198232637 85 + 1.369 0.975 -1.407
ENSG00000151414 E011 0.0000000       1 198245189 198245349 161 +      
ENSG00000151414 E012 67.6454138 0.0040697827 3.409251e-08 3.799249e-07 1 198253040 198253180 141 + 1.534 1.285 -0.860
ENSG00000151414 E013 0.0000000       1 198256328 198256531 204 +      
ENSG00000151414 E014 36.3145103 0.0104725979 3.096147e-05 1.836257e-04 1 198262575 198262637 63 + 1.277 0.975 -1.085
ENSG00000151414 E015 60.2652772 0.0011873773 2.335407e-06 1.790586e-05 1 198264125 198264235 111 + 1.482 1.344 -0.475
ENSG00000151414 E016 0.2944980 0.4437691041 1.000000e+00   1 198277704 198277960 257 + 0.061 0.000 -9.205
ENSG00000151414 E017 67.1604866 0.0003458318 1.481157e-04 7.389089e-04 1 198277961 198278069 109 + 1.520 1.523 0.010
ENSG00000151414 E018 68.3380948 0.0003899325 5.961778e-03 1.850681e-02 1 198278954 198279061 108 + 1.520 1.621 0.345
ENSG00000151414 E019 71.7538996 0.0004958163 2.111986e-03 7.571377e-03 1 198292945 198293039 95 + 1.542 1.621 0.269
ENSG00000151414 E020 72.0762127 0.0005358725 1.293066e-04 6.558174e-04 1 198297127 198297240 114 + 1.548 1.558 0.035
ENSG00000151414 E021 600.0630895 0.0254292196 8.119703e-11 1.454751e-09 1 198319412 198322420 3009 + 2.404 2.916 1.704