ENSG00000151353

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405941 ENSG00000151353 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM18 protein_coding protein_coding 38.12079 42.37095 40.34868 5.480619 0.6664548 -0.07053714 4.804109 8.053938 4.091146 1.5530666 0.31773678 -0.97545734 0.1251750 0.1876000 0.1016667 -0.085933333 0.002404373 0.002404373 FALSE  
ENST00000432667 ENSG00000151353 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM18 protein_coding nonsense_mediated_decay 38.12079 42.37095 40.34868 5.480619 0.6664548 -0.07053714 7.837487 6.641838 8.180409 0.4208383 0.28373769 0.30018238 0.2072958 0.1601667 0.2026333 0.042466667 0.260266758 0.002404373 FALSE  
ENST00000477202 ENSG00000151353 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM18 protein_coding retained_intron 38.12079 42.37095 40.34868 5.480619 0.6664548 -0.07053714 4.486782 4.426116 4.013697 0.2347570 0.05909959 -0.14077534 0.1186333 0.1065667 0.0995000 -0.007066667 0.876980132 0.002404373 TRUE  
MSTRG.17875.1 ENSG00000151353 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM18 protein_coding   38.12079 42.37095 40.34868 5.480619 0.6664548 -0.07053714 16.828993 19.508985 19.930152 2.1443446 0.51994312 0.03079835 0.4393958 0.4625333 0.4938000 0.031266667 0.401198015 0.002404373 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151353 E001 0.2987644 0.0270602033 1.610475e-01   2 662934 663052 119 - 0.236 0.000 -9.733
ENSG00000151353 E002 7.5065461 0.0330320890 3.737275e-01 5.181360e-01 2 663877 664035 159 - 1.001 0.856 -0.544
ENSG00000151353 E003 26.5860436 0.0011913650 5.252268e-04 2.253945e-03 2 664036 664303 268 - 1.561 1.315 -0.847
ENSG00000151353 E004 118.9742074 0.0131098561 5.289277e-08 5.673088e-07 2 664304 667972 3669 - 2.252 1.883 -1.238
ENSG00000151353 E005 6.2511654 0.0089370498 5.306548e-02 1.146005e-01 2 667973 667974 2 - 1.001 0.754 -0.950
ENSG00000151353 E006 238.2315465 0.0073674332 2.561586e-03 8.946991e-03 2 667975 669188 1214 - 2.453 2.313 -0.469
ENSG00000151353 E007 19.7960113 0.0009483682 2.988706e-01 4.403529e-01 2 669189 669210 22 - 1.280 1.350 0.246
ENSG00000151353 E008 268.2350951 0.0002913236 1.177819e-06 9.636549e-06 2 669211 669422 212 - 2.368 2.466 0.325
ENSG00000151353 E009 267.4824769 0.0002487513 5.888983e-11 1.078861e-09 2 669423 669479 57 - 2.341 2.477 0.453
ENSG00000151353 E010 485.0118549 0.0006389293 5.410325e-06 3.821080e-05 2 669480 669675 196 - 2.639 2.712 0.242
ENSG00000151353 E011 350.0491310 0.0008397567 9.723554e-01 9.867542e-01 2 669757 669850 94 - 2.550 2.537 -0.045
ENSG00000151353 E012 24.3592788 0.0176853081 4.480408e-03 1.448588e-02 2 669851 670975 1125 - 1.543 1.251 -1.010
ENSG00000151353 E013 288.0701705 0.0008604524 5.014015e-01 6.375555e-01 2 672808 672862 55 - 2.456 2.458 0.006
ENSG00000151353 E014 310.3738713 0.0001586705 6.299718e-02 1.317011e-01 2 675510 675557 48 - 2.476 2.503 0.088
ENSG00000151353 E015 306.9683166 0.0001794643 6.541281e-02 1.357327e-01 2 675558 675608 51 - 2.471 2.497 0.087
ENSG00000151353 E016 272.1365188 0.0002122844 6.826298e-01 7.860430e-01 2 675609 675630 22 - 2.446 2.426 -0.065
ENSG00000151353 E017 38.9767880 0.0005293191 8.461997e-02 1.667898e-01 2 675631 675757 127 - 1.660 1.555 -0.359
ENSG00000151353 E018 147.6096555 0.0002667856 1.465887e-05 9.374424e-05 2 675758 676238 481 - 2.245 2.108 -0.457
ENSG00000151353 E019 10.8784126 0.0033673064 9.875300e-04 3.916104e-03 2 676239 676573 335 - 1.237 0.890 -1.266
ENSG00000151353 E020 25.6631453 0.0010697837 5.830968e-02 1.237270e-01 2 676574 676787 214 - 1.501 1.362 -0.480
ENSG00000151353 E021 309.9368860 0.0003235875 2.893931e-02 6.988395e-02 2 677289 677406 118 - 2.522 2.466 -0.189