ENSG00000151327

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280987 ENSG00000151327 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM177A1 protein_coding protein_coding 29.64091 39.77796 30.45909 1.04134 0.9844526 -0.3849853 4.241675 3.175584 6.696041 0.2475572 0.32528190 1.0739034 0.1472667 0.08006667 0.21966667 0.13960000 3.266058e-12 4.402949e-31 FALSE TRUE
ENST00000382406 ENSG00000151327 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM177A1 protein_coding protein_coding 29.64091 39.77796 30.45909 1.04134 0.9844526 -0.3849853 8.952012 6.759209 12.509108 0.2355089 0.31825703 0.8870727 0.3154833 0.17003333 0.41090000 0.24086667 4.402949e-31 4.402949e-31 FALSE TRUE
ENST00000554052 ENSG00000151327 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM177A1 protein_coding protein_coding 29.64091 39.77796 30.45909 1.04134 0.9844526 -0.3849853 5.979146 14.538086 1.759008 0.9832260 0.69752346 -3.0398167 0.1929208 0.36720000 0.05666667 -0.31053333 3.569131e-04 4.402949e-31   FALSE
MSTRG.9375.3 ENSG00000151327 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM177A1 protein_coding   29.64091 39.77796 30.45909 1.04134 0.9844526 -0.3849853 9.698040 14.546137 8.492252 1.9639419 0.01000113 -0.7757105 0.3167917 0.36366667 0.27940000 -0.08426667 3.030899e-01 4.402949e-31   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151327 E001 0.0000000       14 35044907 35045116 210 +      
ENSG00000151327 E002 0.1472490 0.0433711726 4.954796e-01   14 35045117 35045194 78 + 0.125 0.000 -11.115
ENSG00000151327 E003 0.5159433 0.2737638637 6.530879e-01 7.636624e-01 14 35045988 35046130 143 + 0.221 0.122 -1.036
ENSG00000151327 E004 7.4136583 0.0074420720 9.626401e-01 9.803983e-01 14 35046236 35046271 36 + 0.920 0.904 -0.060
ENSG00000151327 E005 60.6853795 0.0049479736 7.889135e-01 8.648883e-01 14 35046272 35046377 106 + 1.803 1.764 -0.132
ENSG00000151327 E006 104.0586895 0.0050321694 6.654239e-03 2.032677e-02 14 35046378 35046406 29 + 1.950 2.057 0.359
ENSG00000151327 E007 61.4481149 0.0004240234 7.650816e-02 1.539108e-01 14 35046407 35046452 46 + 1.758 1.813 0.187
ENSG00000151327 E008 95.7490172 0.0003616969 3.558499e-05 2.076791e-04 14 35046453 35046504 52 + 1.906 2.032 0.424
ENSG00000151327 E009 253.4857988 0.0006589058 3.120700e-09 4.219594e-08 14 35046505 35046592 88 + 2.330 2.447 0.390
ENSG00000151327 E010 163.9005046 0.0002637955 9.090504e-05 4.793255e-04 14 35046593 35046603 11 + 2.163 2.247 0.278
ENSG00000151327 E011 191.8869057 0.0002395113 7.185668e-07 6.156122e-06 14 35046604 35046628 25 + 2.220 2.321 0.338
ENSG00000151327 E012 2.5957879 0.3163095803 6.832003e-01 7.864801e-01 14 35046629 35046680 52 + 0.525 0.561 0.168
ENSG00000151327 E013 8.5828426 0.0339011948 7.734530e-01 8.538400e-01 14 35046681 35046954 274 + 0.970 0.982 0.046
ENSG00000151327 E014 1.8842983 0.0074648054 2.587363e-01 3.960410e-01 14 35046955 35047084 130 + 0.564 0.357 -1.064
ENSG00000151327 E015 200.0617897 0.0009017449 8.089170e-81 1.613125e-77 14 35050033 35050396 364 + 1.908 2.465 1.865
ENSG00000151327 E016 1.2565685 0.0108647759 2.757216e-02 6.715603e-02 14 35050784 35050868 85 + 0.522 0.120 -2.870
ENSG00000151327 E017 0.2214452 0.0383904438 4.795000e-01   14 35053200 35053277 78 + 0.000 0.120 10.718
ENSG00000151327 E018 173.1912449 0.0025197091 9.264165e-11 1.643784e-09 14 35053278 35053451 174 + 2.359 2.114 -0.819
ENSG00000151327 E019 0.0000000       14 35054659 35054991 333 +      
ENSG00000151327 E020 114.1132730 0.0013521554 1.522732e-08 1.815006e-07 14 35077150 35077216 67 + 2.171 1.944 -0.763
ENSG00000151327 E021 127.2220960 0.0015134146 1.219520e-09 1.777598e-08 14 35078927 35079024 98 + 2.224 1.987 -0.794
ENSG00000151327 E022 116.0577213 0.0003249489 1.412807e-09 2.037702e-08 14 35081022 35081080 59 + 2.176 1.955 -0.742
ENSG00000151327 E023 167.5305412 0.0005848337 3.480907e-08 3.870381e-07 14 35081081 35081559 479 + 2.316 2.137 -0.597
ENSG00000151327 E024 183.9453178 0.0134301355 1.554476e-09 2.224755e-08 14 35081560 35083381 1822 + 2.434 2.061 -1.247
ENSG00000151327 E025 0.0000000       14 35099652 35099675 24 +      
ENSG00000151327 E026 0.0000000       14 35099676 35099695 20 +      
ENSG00000151327 E027 0.5996172 0.3595630379 9.741567e-01 9.878761e-01 14 35099696 35102680 2985 + 0.222 0.208 -0.120
ENSG00000151327 E028 1.0663564 0.0117391632 2.620039e-01 3.997218e-01 14 35102681 35102729 49 + 0.425 0.214 -1.386
ENSG00000151327 E029 1.1728179 0.0117112709 6.948082e-01 7.955412e-01 14 35106367 35106484 118 + 0.301 0.357 0.352
ENSG00000151327 E030 0.1451727 0.0425920908 4.963813e-01   14 35109895 35109960 66 + 0.125 0.000 -11.116
ENSG00000151327 E031 1.1770843 0.0112209040 6.951279e-01 7.957911e-01 14 35110570 35110642 73 + 0.301 0.357 0.352
ENSG00000151327 E032 0.0000000       14 35110643 35110726 84 +      
ENSG00000151327 E033 0.5483223 0.0208581130 5.573694e-01 6.857868e-01 14 35112864 35113130 267 + 0.125 0.214 0.939