ENSG00000151292

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345990 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding protein_coding 7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 0.7456905 0.05263404 1.1813435 0.05263404 0.5949290 4.249499 0.07790000 0.02053333 0.10290000 0.082366667 6.566132e-01 4.431807e-09 FALSE TRUE
ENST00000361991 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding protein_coding 7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 0.3759755 0.13145636 0.7614162 0.13145636 0.4948010 2.447152 0.07585000 0.07133333 0.06346667 -0.007866667 7.379047e-01 4.431807e-09 FALSE TRUE
ENST00000515322 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding protein_coding 7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 0.2261345 0.87793671 0.0000000 0.37352871 0.0000000 -6.472385 0.10360000 0.36370000 0.00000000 -0.363700000 4.431807e-09 4.431807e-09 FALSE FALSE
ENST00000521364 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding protein_coding 7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 0.1482461 0.39606606 0.0000000 0.39606606 0.0000000 -5.343643 0.02611667 0.15460000 0.00000000 -0.154600000 5.732620e-01 4.431807e-09 FALSE TRUE
MSTRG.26826.10 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding   7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 2.6661981 0.50281631 5.2821866 0.27063586 0.2423965 3.367350 0.33854583 0.24320000 0.45150000 0.208300000 5.602054e-01 4.431807e-09 FALSE TRUE
MSTRG.26826.11 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding   7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 0.8855392 0.00000000 0.3347634 0.00000000 0.3347634 5.107535 0.12630417 0.00000000 0.02740000 0.027400000 1.000000e+00 4.431807e-09 FALSE TRUE
MSTRG.26826.4 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding   7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 1.2751865 0.33011027 2.5833958 0.18066409 0.5360081 2.930768 0.17143333 0.12873333 0.22153333 0.092800000 6.434465e-01 4.431807e-09 FALSE TRUE
MSTRG.26826.7 ENSG00000151292 HEK293_OSMI2_2hA HEK293_TMG_2hB CSNK1G3 protein_coding   7.102588 2.324013 11.69479 0.2405325 0.4794467 2.326215 0.2127810 0.00000000 1.2375275 0.00000000 0.1961024 6.962928 0.02165000 0.00000000 0.10490000 0.104900000 2.221500e-06 4.431807e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151292 E001 0.0000000       5 123511343 123511610 268 +      
ENSG00000151292 E002 0.9179495 0.9049651523 6.227438e-01 0.7394726920 5 123511611 123512175 565 + 0.197 0.286 0.701
ENSG00000151292 E003 0.9179495 0.9049651523 6.227438e-01 0.7394726920 5 123512176 123512176 1 + 0.197 0.286 0.701
ENSG00000151292 E004 5.6768085 0.0100144064 5.289293e-01 0.6617974028 5 123512177 123512190 14 + 0.680 0.672 -0.035
ENSG00000151292 E005 11.0960309 0.0060661790 3.932331e-01 0.5371269925 5 123512191 123512259 69 + 0.927 0.923 -0.015
ENSG00000151292 E006 33.1649955 0.0040944553 2.309018e-02 0.0579355521 5 123512260 123512570 311 + 1.377 1.289 -0.306
ENSG00000151292 E007 0.8899506 0.0140494942 3.881788e-01 0.5322918887 5 123514456 123514472 17 + 0.228 0.000 -11.110
ENSG00000151292 E008 1.4749078 0.0090325935 1.607361e-01 0.2760815666 5 123514473 123514548 76 + 0.332 0.000 -11.846
ENSG00000151292 E009 0.1515154 0.0428936516 1.000000e+00   5 123545415 123545416 2 + 0.047 0.000 -8.525
ENSG00000151292 E010 49.0075789 0.0008768431 1.814199e-03 0.0066445208 5 123545417 123545633 217 + 1.541 1.429 -0.384
ENSG00000151292 E011 66.1922090 0.0228119100 6.785952e-03 0.0206664674 5 123545634 123545841 208 + 1.670 1.544 -0.429
ENSG00000151292 E012 0.0000000       5 123545842 123545956 115 +      
ENSG00000151292 E013 0.0000000       5 123552965 123553106 142 +      
ENSG00000151292 E014 31.8581668 0.0006666817 1.043806e-02 0.0298344716 5 123553107 123553147 41 + 1.360 1.246 -0.400
ENSG00000151292 E015 37.5150800 0.0006593706 4.642359e-02 0.1028007426 5 123557495 123557564 70 + 1.421 1.382 -0.136
ENSG00000151292 E016 57.2256444 0.0706451156 2.014602e-01 0.3280024375 5 123573393 123573541 149 + 1.601 1.560 -0.141
ENSG00000151292 E017 87.6761194 0.0024884500 1.950817e-03 0.0070741794 5 123575729 123575963 235 + 1.785 1.729 -0.190
ENSG00000151292 E018 61.6029360 0.0004104300 4.660548e-03 0.0149867054 5 123588068 123588153 86 + 1.636 1.579 -0.195
ENSG00000151292 E019 0.0000000       5 123588425 123588426 2 +      
ENSG00000151292 E020 60.8449870 0.0004297482 9.014906e-02 0.1753526197 5 123588427 123588511 85 + 1.617 1.638 0.072
ENSG00000151292 E021 11.9456119 0.0015300041 6.812206e-02 0.1402499445 5 123590410 123590412 3 + 0.967 0.816 -0.577
ENSG00000151292 E022 67.6872730 0.0004202405 8.298898e-01 0.8931946856 5 123590413 123590558 146 + 1.648 1.765 0.396
ENSG00000151292 E023 49.5808561 0.0004928151 3.416170e-01 0.4855305529 5 123591319 123591414 96 + 1.526 1.589 0.215
ENSG00000151292 E024 6.8064304 0.0023493377 1.053647e-01 0.1986508553 5 123595039 123595134 96 + 0.765 0.576 -0.800
ENSG00000151292 E025 58.4826911 0.0015179866 6.447562e-02 0.1341745279 5 123604724 123604830 107 + 1.605 1.609 0.015
ENSG00000151292 E026 5.2160227 0.0605430821 4.003474e-02 0.0910991632 5 123605339 123605362 24 + 0.689 0.285 -2.070
ENSG00000151292 E027 413.2207582 0.0296640453 6.438846e-05 0.0003529061 5 123614342 123617045 2704 + 2.384 2.725 1.137