ENSG00000151240

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280886 ENSG00000151240 HEK293_OSMI2_2hA HEK293_TMG_2hB DIP2C protein_coding protein_coding 3.319958 2.913191 4.306904 0.114949 0.2562579 0.5624531 1.1078367 0.4754705 2.4554338 0.13339679 0.26422873 2.344386 0.32455000 0.16660000 0.5685667 0.4019667 1.327529e-04 1.481252e-05 FALSE TRUE
ENST00000381496 ENSG00000151240 HEK293_OSMI2_2hA HEK293_TMG_2hB DIP2C protein_coding protein_coding 3.319958 2.913191 4.306904 0.114949 0.2562579 0.5624531 1.4427965 2.2561126 0.2124205 0.24947333 0.21242050 -3.348858 0.47110833 0.77110000 0.0549000 -0.7162000 4.261221e-03 1.481252e-05 FALSE TRUE
ENST00000421992 ENSG00000151240 HEK293_OSMI2_2hA HEK293_TMG_2hB DIP2C protein_coding protein_coding 3.319958 2.913191 4.306904 0.114949 0.2562579 0.5624531 0.1419482 0.0000000 0.4404232 0.00000000 0.28509372 5.493209 0.03347083 0.00000000 0.0952000 0.0952000 2.487593e-01 1.481252e-05 FALSE TRUE
MSTRG.3463.3 ENSG00000151240 HEK293_OSMI2_2hA HEK293_TMG_2hB DIP2C protein_coding   3.319958 2.913191 4.306904 0.114949 0.2562579 0.5624531 0.5806685 0.1639036 1.1986269 0.04760284 0.04863148 2.797010 0.15661250 0.05583333 0.2813667 0.2255333 1.481252e-05 1.481252e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151240 E001 0.1817044 0.0398608761 4.275316e-01   10 274190 274200 11 - 0.000 0.133 9.054
ENSG00000151240 E002 232.8969976 0.0057084750 6.182678e-09 7.933955e-08 10 274201 277132 2932 - 2.229 2.475 0.821
ENSG00000151240 E003 28.7219533 0.0007056949 2.039894e-01 3.311681e-01 10 277133 277198 66 - 1.418 1.521 0.356
ENSG00000151240 E004 37.4260939 0.0005511394 1.543986e-01 2.676195e-01 10 277199 277322 124 - 1.530 1.632 0.349
ENSG00000151240 E005 50.7669249 0.0004401283 6.162935e-03 1.904090e-02 10 277323 277577 255 - 1.628 1.784 0.528
ENSG00000151240 E006 36.0807635 0.0007119882 9.104073e-03 2.654303e-02 10 281200 281323 124 - 1.473 1.646 0.592
ENSG00000151240 E007 48.2928628 0.0004897336 5.041661e-03 1.604421e-02 10 283272 283446 175 - 1.600 1.763 0.553
ENSG00000151240 E008 31.1783636 0.0007766851 3.649848e-02 8.452803e-02 10 286273 286347 75 - 1.418 1.570 0.523
ENSG00000151240 E009 30.8794375 0.0038986552 3.221408e-02 7.626384e-02 10 288364 288421 58 - 1.408 1.575 0.574
ENSG00000151240 E010 27.5305745 0.0110079378 3.866247e-01 5.307986e-01 10 310031 310092 62 - 1.403 1.494 0.314
ENSG00000151240 E011 0.1817044 0.0398608761 4.275316e-01   10 311537 311566 30 - 0.000 0.133 11.754
ENSG00000151240 E012 0.0000000       10 324639 325019 381 -      
ENSG00000151240 E013 37.5274349 0.0021908939 4.837819e-02 1.062929e-01 10 327006 327176 171 - 1.510 1.650 0.476
ENSG00000151240 E014 32.2036413 0.0033392971 8.745877e-01 9.233577e-01 10 329433 329601 169 - 1.506 1.539 0.112
ENSG00000151240 E015 28.3292181 0.0094610681 8.868202e-01 9.316296e-01 10 341199 341329 131 - 1.464 1.475 0.037
ENSG00000151240 E016 25.8939963 0.0090995631 3.300330e-01 4.736254e-01 10 344809 344918 110 - 1.456 1.398 -0.199
ENSG00000151240 E017 19.3423819 0.0032220080 6.170830e-01 7.349620e-01 10 344999 345110 112 - 1.319 1.300 -0.065
ENSG00000151240 E018 16.0752982 0.0011446055 1.624800e-01 2.783752e-01 10 348641 348762 122 - 1.280 1.185 -0.336
ENSG00000151240 E019 18.2410679 0.0010561658 2.913356e-01 4.321920e-01 10 349331 349454 124 - 1.313 1.251 -0.217
ENSG00000151240 E020 16.3805801 0.0011023751 9.265122e-02 1.792681e-01 10 356426 356506 81 - 1.293 1.175 -0.418
ENSG00000151240 E021 19.6817281 0.0017495479 2.259783e-01 3.575680e-01 10 357828 357937 110 - 1.349 1.276 -0.252
ENSG00000151240 E022 28.4006451 0.0008425036 3.722338e-01 5.166839e-01 10 362490 362691 202 - 1.486 1.450 -0.123
ENSG00000151240 E023 24.3535743 0.0007980914 3.058046e-01 4.479426e-01 10 363197 363311 115 - 1.427 1.378 -0.170
ENSG00000151240 E024 35.7025576 0.0006515469 6.507691e-03 1.994213e-02 10 364374 364582 209 - 1.628 1.492 -0.464
ENSG00000151240 E025 1.0256575 0.2971813631 6.288286e-01 7.443094e-01 10 364962 365021 60 - 0.338 0.241 -0.667
ENSG00000151240 E026 30.1051653 0.0080231088 4.030024e-03 1.322563e-02 10 366275 366411 137 - 1.577 1.380 -0.677
ENSG00000151240 E027 25.4001907 0.0008185548 2.447323e-02 6.079859e-02 10 369494 369633 140 - 1.477 1.345 -0.458
ENSG00000151240 E028 25.4382149 0.0008073977 2.239570e-01 3.551380e-01 10 382647 382761 115 - 1.446 1.385 -0.211
ENSG00000151240 E029 28.8392295 0.0014560818 7.466259e-03 2.242754e-02 10 384027 384146 120 - 1.545 1.391 -0.528
ENSG00000151240 E030 25.7305262 0.0011952487 8.649995e-02 1.698081e-01 10 384546 384639 94 - 1.473 1.378 -0.327
ENSG00000151240 E031 20.2448926 0.0009751279 2.061863e-01 3.339292e-01 10 387745 387809 65 - 1.366 1.292 -0.256
ENSG00000151240 E032 25.7981743 0.0007695079 4.257782e-01 5.686828e-01 10 389991 390093 103 - 1.442 1.410 -0.110
ENSG00000151240 E033 25.1345820 0.0044691544 4.816419e-01 6.198347e-01 10 390264 390373 110 - 1.432 1.403 -0.101
ENSG00000151240 E034 23.8819898 0.0008453562 5.176758e-01 6.520146e-01 10 390740 390863 124 - 1.408 1.385 -0.080
ENSG00000151240 E035 19.4804442 0.0041982932 2.437604e-01 3.785965e-01 10 399109 399219 111 - 1.343 1.269 -0.259
ENSG00000151240 E036 20.1957455 0.0009373843 5.044213e-01 6.403269e-01 10 408926 409017 92 - 1.337 1.308 -0.101
ENSG00000151240 E037 24.4240257 0.0027714810 9.284887e-03 2.699665e-02 10 413913 414110 198 - 1.477 1.308 -0.585
ENSG00000151240 E038 20.8061056 0.0011390335 4.523832e-04 1.976081e-03 10 415769 415888 120 - 1.442 1.195 -0.861
ENSG00000151240 E039 25.1885001 0.0008532519 8.001357e-04 3.260207e-03 10 419065 419199 135 - 1.510 1.300 -0.727
ENSG00000151240 E040 29.4680835 0.0006867694 1.064449e-04 5.516831e-04 10 422824 423033 210 - 1.580 1.352 -0.785
ENSG00000151240 E041 21.2179991 0.0207501503 3.209600e-02 7.604321e-02 10 440871 440996 126 - 1.423 1.231 -0.668
ENSG00000151240 E042 21.8355420 0.0292680173 2.239474e-01 3.551288e-01 10 472439 472549 111 - 1.402 1.293 -0.378
ENSG00000151240 E043 4.6910255 0.0074770793 2.023307e-01 3.291342e-01 10 484781 484945 165 - 0.821 0.661 -0.651
ENSG00000151240 E044 1.5124836 0.0104643076 8.381607e-02 1.655256e-01 10 484946 484948 3 - 0.527 0.234 -1.727
ENSG00000151240 E045 11.7640968 0.0014842447 7.394875e-03 2.224521e-02 10 486459 486530 72 - 1.207 0.965 -0.875
ENSG00000151240 E046 0.0000000       10 486531 486558 28 -      
ENSG00000151240 E047 8.9691141 0.0018339355 1.643861e-04 8.109044e-04 10 689494 689755 262 - 1.156 0.752 -1.518