ENSG00000151239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395510 ENSG00000151239 HEK293_OSMI2_2hA HEK293_TMG_2hB TWF1 protein_coding protein_coding 26.12227 5.316299 45.5796 0.4773889 2.231693 3.097499 22.32677 5.1423 39.72147 0.506609 1.300928 2.946994 0.8949667 0.9657333 0.8729667 -0.09276667 0.001550471 0.001550471 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151239 E001 0.7717566 0.0243422064 3.393723e-04 1.537902e-03 12 43793723 43793724 2 - 0.041 0.721 5.424
ENSG00000151239 E002 660.7821871 0.0110873670 1.024689e-08 1.260874e-07 12 43793725 43795492 1768 - 2.557 2.871 1.043
ENSG00000151239 E003 104.9127579 0.0003189757 6.839648e-02 1.407186e-01 12 43795493 43795555 63 - 1.808 1.806 -0.005
ENSG00000151239 E004 162.5535245 0.0002151293 6.836832e-02 1.406713e-01 12 43795556 43795704 149 - 1.994 2.015 0.071
ENSG00000151239 E005 110.2845805 0.0002481406 3.073076e-02 7.338682e-02 12 43795705 43795755 51 - 1.831 1.814 -0.060
ENSG00000151239 E006 162.4023730 0.0002399224 2.502656e-03 8.771079e-03 12 43796976 43797097 122 - 1.999 1.963 -0.123
ENSG00000151239 E007 135.9592166 0.0017500378 8.200057e-04 3.330924e-03 12 43797302 43797452 151 - 1.926 1.841 -0.284
ENSG00000151239 E008 133.7151962 0.0002936241 7.563548e-03 2.267915e-02 12 43797708 43797833 126 - 1.914 1.880 -0.115
ENSG00000151239 E009 0.2966881 0.0269700866 1.000000e+00   12 43797834 43797851 18 - 0.079 0.000 -8.381
ENSG00000151239 E010 0.5933762 0.0221791677 1.000000e+00 1.000000e+00 12 43798565 43798585 21 - 0.145 0.000 -9.381
ENSG00000151239 E011 85.8952603 0.0003465045 1.328224e-01 2.380385e-01 12 43799398 43799416 19 - 1.720 1.727 0.025
ENSG00000151239 E012 98.0311599 0.0003136420 1.763327e-01 2.964705e-01 12 43799417 43799461 45 - 1.776 1.799 0.078
ENSG00000151239 E013 85.5296058 0.0009242271 1.950040e-01 3.199879e-01 12 43799462 43799502 41 - 1.717 1.736 0.063
ENSG00000151239 E014 92.6949424 0.0006019958 5.075516e-02 1.105144e-01 12 43800435 43800473 39 - 1.754 1.736 -0.063
ENSG00000151239 E015 85.5592490 0.0003336539 2.531844e-02 6.252612e-02 12 43800474 43800530 57 - 1.723 1.681 -0.141
ENSG00000151239 E016 0.1515154 0.0431679706 6.595725e-01   12 43802284 43802285 2 - 0.041 0.000 -7.381
ENSG00000151239 E017 95.8608882 0.0017355922 5.123660e-04 2.205950e-03 12 43802286 43802464 179 - 1.781 1.651 -0.438
ENSG00000151239 E018 0.7406253 0.0154384134 8.553491e-01 9.105743e-01 12 43804153 43804175 23 - 0.175 0.000 -9.703
ENSG00000151239 E019 4.0506023 0.0044696630 1.937730e-01 3.185163e-01 12 43804176 43804240 65 - 0.554 0.316 -1.270
ENSG00000151239 E020 1.3297351 0.0099770582 3.540460e-01 4.983206e-01 12 43804241 43804494 254 - 0.277 0.000 -10.550
ENSG00000151239 E021 53.6296434 0.0015130679 7.888759e-03 2.350030e-02 12 43804495 43804572 78 - 1.535 1.408 -0.439
ENSG00000151239 E022 1.3232906 0.0154190052 3.155371e-01 4.583008e-01 12 43805524 43805637 114 - 0.229 0.496 1.620
ENSG00000151239 E023 4.9272271 0.0031968629 3.721155e-01 5.165849e-01 12 43805831 43805885 55 - 0.610 0.496 -0.525
ENSG00000151239 E024 5.7398585 0.0027660984 5.873070e-01 7.106132e-01 12 43805886 43806002 117 - 0.650 0.624 -0.115
ENSG00000151239 E025 1.8498310 0.0322324214 8.215471e-01 8.874572e-01 12 43806003 43806220 218 - 0.320 0.316 -0.027
ENSG00000151239 E026 38.8382739 0.0207498874 1.045069e-02 2.986518e-02 12 43806221 43806328 108 - 1.407 1.172 -0.823