ENSG00000151233

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280876 ENSG00000151233 HEK293_OSMI2_2hA HEK293_TMG_2hB GXYLT1 protein_coding protein_coding 9.662878 1.785327 14.11289 0.141079 0.3178012 2.975717 0.7597097 0.04215629 1.101583 0.02725553 0.1964134 4.413630 0.0543250 0.025 0.0783000 0.0533000 2.132044e-01 6.235145e-26 FALSE TRUE
ENST00000398675 ENSG00000151233 HEK293_OSMI2_2hA HEK293_TMG_2hB GXYLT1 protein_coding protein_coding 9.662878 1.785327 14.11289 0.141079 0.3178012 2.975717 4.8874172 1.74317028 6.057508 0.15461115 0.2021968 1.791138 0.6865500 0.975 0.4290667 -0.5459333 6.235145e-26 6.235145e-26 FALSE TRUE
MSTRG.7122.2 ENSG00000151233 HEK293_OSMI2_2hA HEK293_TMG_2hB GXYLT1 protein_coding   9.662878 1.785327 14.11289 0.141079 0.3178012 2.975717 3.8774305 0.00000000 6.851724 0.00000000 0.3562888 9.422427 0.2489458 0.000 0.4853000 0.4853000 1.446471e-22 6.235145e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151233 E001 221.5940102 0.0002745869 7.289184e-66 9.145126e-63 12 42081845 42083699 1855 - 2.116 2.539 1.413
ENSG00000151233 E002 159.5337238 0.0002706427 5.189050e-06 3.679243e-05 12 42083700 42084193 494 - 2.052 2.200 0.493
ENSG00000151233 E003 125.2424473 0.0011865534 6.941695e-02 1.423913e-01 12 42084194 42084593 400 - 1.964 2.034 0.234
ENSG00000151233 E004 315.5467028 0.0049156627 3.925748e-03 1.293428e-02 12 42084594 42086354 1761 - 2.395 2.277 -0.391
ENSG00000151233 E005 159.1301047 0.0003184032 4.366805e-16 1.727815e-14 12 42086355 42087144 790 - 2.127 1.749 -1.270
ENSG00000151233 E006 171.0519788 0.0008031255 5.599406e-03 1.755163e-02 12 42087145 42087947 803 - 2.132 2.017 -0.386
ENSG00000151233 E007 64.6880103 0.0004148959 7.147707e-04 2.951613e-03 12 42097442 42097572 131 - 1.730 1.501 -0.782
ENSG00000151233 E008 44.0276987 0.0005267536 1.033929e-03 4.075884e-03 12 42097573 42097614 42 - 1.572 1.298 -0.945
ENSG00000151233 E009 67.3444752 0.0003661558 1.642842e-05 1.039066e-04 12 42097910 42098033 124 - 1.752 1.455 -1.010
ENSG00000151233 E010 82.1847561 0.0003361551 4.281515e-06 3.092338e-05 12 42105818 42106069 252 - 1.836 1.552 -0.965
ENSG00000151233 E011 43.1052582 0.0005145461 3.089688e-01 4.512552e-01 12 42109566 42109691 126 - 1.538 1.455 -0.283
ENSG00000151233 E012 35.7569515 0.0006131643 1.737453e-01 2.930540e-01 12 42119000 42119171 172 - 1.466 1.347 -0.412
ENSG00000151233 E013 0.7384352 0.0179344932 5.011537e-01 6.373185e-01 12 42128046 42128228 183 - 0.223 0.000 -10.461
ENSG00000151233 E014 7.5071880 0.0021255503 6.115353e-02 1.285719e-01 12 42129759 42129851 93 - 0.865 0.526 -1.422
ENSG00000151233 E015 0.1515154 0.0421884720 1.000000e+00   12 42133881 42133936 56 - 0.055 0.000 -8.140
ENSG00000151233 E016 21.4635234 0.0008871165 6.491879e-03 1.990205e-02 12 42144426 42144874 449 - 1.273 0.948 -1.175
ENSG00000151233 E017 0.2965864 0.2245187089 1.699612e-02   12 42153113 42153188 76 - 0.000 0.404 13.922