ENSG00000151229

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280871 ENSG00000151229 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A13 protein_coding protein_coding 2.6954 1.201206 3.945652 0.2435484 0.3339586 1.707472 1.32365532 0.2341760 1.99747267 0.02625747 0.05129141 3.03938722 0.39713750 0.22200000 0.51566667 0.29366667 0.03007971 0.03007971 FALSE TRUE
ENST00000380858 ENSG00000151229 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A13 protein_coding protein_coding 2.6954 1.201206 3.945652 0.2435484 0.3339586 1.707472 0.05269438 0.0842298 0.06411454 0.02320108 0.01841349 -0.34642678 0.02923333 0.08206667 0.01716667 -0.06490000 0.12985312 0.03007971 FALSE TRUE
ENST00000465517 ENSG00000151229 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A13 protein_coding retained_intron 2.6954 1.201206 3.945652 0.2435484 0.3339586 1.707472 0.08345703 0.1282589 0.12498716 0.04769504 0.02086272 -0.03455022 0.03647917 0.09853333 0.03190000 -0.06663333 0.11318772 0.03007971 FALSE TRUE
ENST00000505338 ENSG00000151229 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A13 protein_coding retained_intron 2.6954 1.201206 3.945652 0.2435484 0.3339586 1.707472 0.35558492 0.2263741 0.35639870 0.17668983 0.05327084 0.63234225 0.16390000 0.16173333 0.09000000 -0.07173333 0.89948801 0.03007971   FALSE
MSTRG.7114.2 ENSG00000151229 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A13 protein_coding   2.6954 1.201206 3.945652 0.2435484 0.3339586 1.707472 0.35953073 0.1156807 0.97004262 0.07403187 0.11183373 2.96308167 0.12197917 0.13363333 0.24450000 0.11086667 0.54062386 0.03007971 TRUE TRUE
MSTRG.7114.6 ENSG00000151229 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A13 protein_coding   2.6954 1.201206 3.945652 0.2435484 0.3339586 1.707472 0.47791207 0.4124862 0.43263642 0.20658349 0.23070528 0.06721783 0.21362917 0.30196667 0.10076667 -0.20120000 0.74336225 0.03007971 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151229 E001 132.3720638 0.0067725702 3.988930e-04 0.0017700577 12 39755025 39760068 5044 - 2.057 1.887 -0.570
ENSG00000151229 E002 16.5442257 0.0012002534 3.436396e-04 0.0015545882 12 39760069 39760252 184 - 1.216 0.726 -1.840
ENSG00000151229 E003 15.7410547 0.0012031437 8.280044e-03 0.0244918508 12 39764460 39764612 153 - 1.180 0.830 -1.295
ENSG00000151229 E004 11.3853347 0.0017895401 2.832897e-03 0.0097726373 12 39764737 39764858 122 - 1.064 0.589 -1.881
ENSG00000151229 E005 0.5910844 0.0234383980 1.232045e-01 0.2245466570 12 39822629 39822661 33 - 0.112 0.386 2.285
ENSG00000151229 E006 1.4790724 0.0159772748 7.677605e-01 0.8499195156 12 39822662 39822718 57 - 0.338 0.387 0.286
ENSG00000151229 E007 1.9230055 0.0148326010 4.331454e-03 0.0140734562 12 39829408 39830102 695 - 0.240 0.727 2.556
ENSG00000151229 E008 7.2443504 0.0047652039 3.135700e-02 0.0745992651 12 39830103 39830124 22 - 0.890 0.499 -1.650
ENSG00000151229 E009 10.9861203 0.0035570142 3.402079e-01 0.4841707509 12 39830125 39830228 104 - 1.018 0.873 -0.541
ENSG00000151229 E010 2.5055848 0.0083689180 1.084278e-02 0.0307891965 12 39830229 39830327 99 - 0.366 0.780 1.925
ENSG00000151229 E011 2.6237908 0.0061638540 1.825205e-01 0.3043780620 12 39830328 39830480 153 - 0.442 0.662 1.025
ENSG00000151229 E012 0.0000000       12 39835681 39835760 80 -      
ENSG00000151229 E013 15.7890692 0.0012799020 1.620439e-01 0.2777737419 12 39864762 39864882 121 - 1.106 1.226 0.427
ENSG00000151229 E014 19.8309191 0.0016074915 5.381790e-02 0.1159372799 12 39871798 39871961 164 - 1.188 1.340 0.533
ENSG00000151229 E015 3.8256506 0.0043575653 2.569601e-05 0.0001553247 12 39949490 39951256 1767 - 0.418 1.015 2.529
ENSG00000151229 E016 17.3421819 0.0032397012 2.746498e-02 0.0669380135 12 39951257 39951365 109 - 1.121 1.311 0.670
ENSG00000151229 E017 24.4067443 0.0008862113 1.043211e-04 0.0005419595 12 40028301 40028509 209 - 1.239 1.514 0.954
ENSG00000151229 E018 13.2467211 0.0245293620 1.738558e-01 0.2932020736 12 40048051 40048210 160 - 1.035 1.184 0.537
ENSG00000151229 E019 0.0000000       12 40048211 40048221 11 -      
ENSG00000151229 E020 1.3673109 0.0097920126 6.496164e-01 0.7608383929 12 40092755 40092805 51 - 0.308 0.387 0.481
ENSG00000151229 E021 20.7698262 0.0011016843 2.700483e-01 0.4086249360 12 40105253 40106089 837 - 1.232 1.310 0.275