ENSG00000151208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372391 ENSG00000151208 HEK293_OSMI2_2hA HEK293_TMG_2hB DLG5 protein_coding protein_coding 17.89269 22.38033 14.95297 0.6829095 0.08773562 -0.5814794 8.939185 8.4205683 9.760622 0.94869331 0.04676578 0.2128205 0.52099167 0.37440000 0.65286667 0.2784667 6.201748e-08 1.105731e-11 FALSE TRUE
ENST00000424842 ENSG00000151208 HEK293_OSMI2_2hA HEK293_TMG_2hB DLG5 protein_coding protein_coding 17.89269 22.38033 14.95297 0.6829095 0.08773562 -0.5814794 7.062905 12.9510353 3.146906 0.36400527 0.25967255 -2.0375975 0.36270833 0.58066667 0.21026667 -0.3704000 1.105731e-11 1.105731e-11 FALSE TRUE
MSTRG.4240.4 ENSG00000151208 HEK293_OSMI2_2hA HEK293_TMG_2hB DLG5 protein_coding   17.89269 22.38033 14.95297 0.6829095 0.08773562 -0.5814794 0.677658 0.2604649 1.026916 0.07153257 0.21006051 1.9387850 0.04347917 0.01153333 0.06883333 0.0573000 9.708218e-05 1.105731e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151208 E001 734.7159086 0.0058374744 1.215814e-17 5.896884e-16 10 77790791 77791708 918 - 2.620 2.962 1.139
ENSG00000151208 E002 254.8492258 0.0008210690 2.839986e-05 1.698585e-04 10 77791709 77791900 192 - 2.311 2.446 0.451
ENSG00000151208 E003 284.8593628 0.0002114951 1.066771e-07 1.078078e-06 10 77791901 77792195 295 - 2.350 2.494 0.477
ENSG00000151208 E004 250.1889334 0.0001783298 6.077848e-09 7.811602e-08 10 77792196 77792543 348 - 2.283 2.445 0.541
ENSG00000151208 E005 2.6174204 0.0062840936 1.170898e-01 2.157918e-01 10 77793544 77794007 464 - 0.669 0.437 -1.082
ENSG00000151208 E006 168.1543700 0.0003313368 4.822340e-01 6.203969e-01 10 77794008 77794117 110 - 2.191 2.235 0.149
ENSG00000151208 E007 172.4187679 0.0046761160 8.964664e-01 9.378109e-01 10 77794849 77794958 110 - 2.217 2.238 0.069
ENSG00000151208 E008 178.7555341 0.0055499771 4.589445e-01 5.991790e-01 10 77796061 77796188 128 - 2.209 2.266 0.193
ENSG00000151208 E009 164.4720365 0.0003400519 3.396246e-02 7.968008e-02 10 77796451 77796594 144 - 2.154 2.240 0.288
ENSG00000151208 E010 184.1183372 0.0001878344 2.164975e-01 3.461894e-01 10 77805665 77805861 197 - 2.219 2.277 0.193
ENSG00000151208 E011 1.9112782 0.0101959709 6.131156e-01 7.319117e-01 10 77805862 77805928 67 - 0.505 0.436 -0.347
ENSG00000151208 E012 1.6929403 0.0116277483 8.492240e-01 9.064204e-01 10 77806105 77806171 67 - 0.452 0.436 -0.086
ENSG00000151208 E013 95.2922952 0.0003228896 8.118487e-01 8.806215e-01 10 77806758 77806795 38 - 1.960 1.976 0.052
ENSG00000151208 E014 154.4266408 0.0002696508 6.397555e-01 7.530882e-01 10 77806796 77806928 133 - 2.173 2.184 0.036
ENSG00000151208 E015 164.3475814 0.0026783609 9.190017e-01 9.528349e-01 10 77807796 77807936 141 - 2.195 2.216 0.071
ENSG00000151208 E016 91.1088999 0.0004150838 9.279577e-01 9.586428e-01 10 77807937 77807944 8 - 1.942 1.963 0.070
ENSG00000151208 E017 0.6600969 0.0565878960 7.720011e-01 8.528585e-01 10 77807945 77807977 33 - 0.239 0.198 -0.344
ENSG00000151208 E018 177.1940248 0.0002364024 5.783468e-01 7.034666e-01 10 77809547 77809730 184 - 2.233 2.242 0.031
ENSG00000151208 E019 124.9448767 0.0010687343 5.940521e-01 7.163359e-01 10 77811094 77811234 141 - 2.060 2.103 0.146
ENSG00000151208 E020 111.4764557 0.0032807855 8.378833e-01 8.986428e-01 10 77811924 77812057 134 - 2.029 2.045 0.051
ENSG00000151208 E021 124.5133547 0.0002387892 6.631828e-01 7.713103e-01 10 77812215 77812377 163 - 2.064 2.102 0.129
ENSG00000151208 E022 1.8475737 0.0161831316 1.602492e-02 4.279071e-02 10 77816033 77816175 143 - 0.136 0.589 2.972
ENSG00000151208 E023 132.9686750 0.0003137585 2.838027e-01 4.239869e-01 10 77816551 77816701 151 - 2.077 2.136 0.196
ENSG00000151208 E024 100.4249074 0.0004078790 2.763512e-01 4.158042e-01 10 77817007 77817096 90 - 1.953 2.017 0.216
ENSG00000151208 E025 94.3980326 0.0016728183 8.902000e-01 9.338528e-01 10 77817777 77817889 113 - 1.948 1.978 0.101
ENSG00000151208 E026 105.8772605 0.0051716290 7.711307e-01 8.522498e-01 10 77819321 77819465 145 - 2.009 2.020 0.035
ENSG00000151208 E027 1.5606435 0.0089020947 1.705656e-02 4.506147e-02 10 77819466 77819476 11 - 0.595 0.198 -2.346
ENSG00000151208 E028 7.3692157 0.0359876656 6.692199e-02 1.382540e-01 10 77819477 77819894 418 - 1.038 0.795 -0.924
ENSG00000151208 E029 93.2842353 0.0159488711 6.556628e-01 7.655017e-01 10 77819895 77820018 124 - 1.965 1.959 -0.019
ENSG00000151208 E030 16.6333202 0.0010850409 2.451307e-02 6.087761e-02 10 77820019 77821081 1063 - 1.326 1.163 -0.573
ENSG00000151208 E031 243.7205414 0.0020046884 2.378913e-02 5.938020e-02 10 77821082 77821781 700 - 2.403 2.359 -0.146
ENSG00000151208 E032 153.3597710 0.0016180630 3.466045e-02 8.099966e-02 10 77821782 77822101 320 - 2.204 2.157 -0.157
ENSG00000151208 E033 78.7825816 0.0004903676 5.677365e-02 1.210712e-01 10 77824384 77824476 93 - 1.918 1.865 -0.180
ENSG00000151208 E034 1.1802934 0.0113849563 4.484884e-01 5.897711e-01 10 77824477 77824730 254 - 0.392 0.271 -0.760
ENSG00000151208 E035 90.9586454 0.0003841866 9.887980e-03 2.848787e-02 10 77828882 77828985 104 - 1.992 1.919 -0.245
ENSG00000151208 E036 132.0888878 0.0003362067 6.450865e-06 4.478350e-05 10 77829355 77829530 176 - 2.179 2.062 -0.392
ENSG00000151208 E037 134.5687363 0.0002565186 1.315483e-08 1.586240e-07 10 77830217 77830344 128 - 2.204 2.053 -0.504
ENSG00000151208 E038 121.4445901 0.0051789485 2.490531e-05 1.511141e-04 10 77830741 77830873 133 - 2.171 1.998 -0.580
ENSG00000151208 E039 98.8719710 0.0064839569 1.655194e-03 6.138229e-03 10 77833914 77834039 126 - 2.066 1.927 -0.466
ENSG00000151208 E040 129.1506309 0.0027706866 1.965067e-08 2.294884e-07 10 77835738 77835922 185 - 2.211 2.013 -0.662
ENSG00000151208 E041 164.1557490 0.0042766454 8.030904e-07 6.805470e-06 10 77841881 77842193 313 - 2.305 2.128 -0.594
ENSG00000151208 E042 131.2585983 0.0002522709 5.207300e-11 9.641121e-10 10 77843447 77843706 260 - 2.209 2.029 -0.601
ENSG00000151208 E043 0.3299976 0.0274424043 2.922581e-01   10 77845211 77845437 227 - 0.000 0.198 9.344
ENSG00000151208 E044 104.1934115 0.0002605025 2.949966e-13 7.844780e-12 10 77853354 77853537 184 - 2.135 1.907 -0.765
ENSG00000151208 E045 82.2330979 0.0003232992 1.358549e-11 2.769238e-10 10 77854227 77854358 132 - 2.040 1.802 -0.801
ENSG00000151208 E046 28.3143320 0.0102354254 4.581086e-03 1.476703e-02 10 77854359 77854370 12 - 1.572 1.369 -0.697
ENSG00000151208 E047 70.6796302 0.0003558892 2.036679e-07 1.948701e-06 10 77856730 77856892 163 - 1.951 1.758 -0.651
ENSG00000151208 E048 0.0000000       10 77869099 77869128 30 -      
ENSG00000151208 E049 36.2482088 0.0009944003 9.860581e-04 3.911179e-03 10 77869129 77869197 69 - 1.650 1.480 -0.581
ENSG00000151208 E050 0.0000000       10 77889429 77889507 79 -      
ENSG00000151208 E051 50.9955531 0.0184362132 8.457993e-04 3.422636e-03 10 77926217 77926935 719 - 1.831 1.591 -0.814