ENSG00000151176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280800 ENSG00000151176 HEK293_OSMI2_2hA HEK293_TMG_2hB PLBD2 protein_coding protein_coding 15.91039 17.70333 12.98306 1.139674 0.537761 -0.4470945 11.385855 9.359992 11.309342 2.3015416 0.3602582 0.2726703 0.7237917 0.51600000 0.8720333 0.35603333 2.818403e-03 8.149906e-16 FALSE TRUE
ENST00000545182 ENSG00000151176 HEK293_OSMI2_2hA HEK293_TMG_2hB PLBD2 protein_coding protein_coding 15.91039 17.70333 12.98306 1.139674 0.537761 -0.4470945 1.531160 1.314899 1.194259 0.4739481 0.2605169 -0.1377360 0.0940750 0.07586667 0.0928000 0.01693333 8.170427e-01 8.149906e-16 FALSE TRUE
MSTRG.8070.3 ENSG00000151176 HEK293_OSMI2_2hA HEK293_TMG_2hB PLBD2 protein_coding   15.91039 17.70333 12.98306 1.139674 0.537761 -0.4470945 2.763514 6.948614 0.000000 1.0268279 0.0000000 -9.4426562 0.1678417 0.40373333 0.0000000 -0.40373333 8.149906e-16 8.149906e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151176 E001 2.0003393 0.0336890505 6.926062e-02 1.421445e-01 12 113358566 113358586 21 + 0.588 0.366 -1.115
ENSG00000151176 E002 23.1403705 0.0008179917 1.845544e-10 3.110336e-09 12 113358587 113358753 167 + 1.521 1.203 -1.106
ENSG00000151176 E003 56.4645845 0.0007191058 1.033412e-13 2.932108e-12 12 113358754 113358890 137 + 1.852 1.643 -0.708
ENSG00000151176 E004 70.6401893 0.0154026470 2.782710e-04 1.291275e-03 12 113369116 113369209 94 + 1.903 1.795 -0.364
ENSG00000151176 E005 106.0454598 0.0036137679 7.112428e-07 6.098891e-06 12 113372649 113372807 159 + 2.060 1.989 -0.237
ENSG00000151176 E006 84.8488152 0.0003682022 6.262888e-05 3.443080e-04 12 113374474 113374574 101 + 1.932 1.923 -0.028
ENSG00000151176 E007 85.9723628 0.0003305609 4.627288e-07 4.120837e-06 12 113374793 113374865 73 + 1.960 1.914 -0.153
ENSG00000151176 E008 115.5691455 0.0004417190 1.994791e-09 2.793105e-08 12 113374866 113375007 142 + 2.090 2.036 -0.180
ENSG00000151176 E009 0.5932745 0.0431716343 7.682169e-01 8.502596e-01 12 113375008 113375165 158 + 0.214 0.220 0.053
ENSG00000151176 E010 1.0255689 0.0121989077 6.440763e-01 7.564682e-01 12 113376789 113377086 298 + 0.214 0.367 1.061
ENSG00000151176 E011 104.8588305 0.0017478775 2.396889e-05 1.460451e-04 12 113380745 113380842 98 + 2.030 2.011 -0.063
ENSG00000151176 E012 139.4682020 0.0027904893 1.827035e-04 8.895561e-04 12 113384105 113384265 161 + 2.140 2.145 0.018
ENSG00000151176 E013 93.0907678 0.0093805545 6.104373e-03 1.888398e-02 12 113384851 113384946 96 + 1.975 1.968 -0.022
ENSG00000151176 E014 90.6856037 0.0099489382 2.043357e-02 5.240251e-02 12 113385212 113385283 72 + 1.954 1.968 0.048
ENSG00000151176 E015 105.4445558 0.0045608595 8.750486e-04 3.526985e-03 12 113386937 113387089 153 + 2.027 2.023 -0.015
ENSG00000151176 E016 102.8304523 0.0026911390 3.601927e-02 8.362532e-02 12 113387744 113387892 149 + 1.981 2.040 0.199
ENSG00000151176 E017 42.6320829 0.0068993116 3.507709e-01 4.949444e-01 12 113387893 113387906 14 + 1.586 1.671 0.287
ENSG00000151176 E018 1465.9148015 0.0091032096 7.850931e-12 1.662384e-10 12 113388459 113391629 3171 + 2.970 3.283 1.039